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ObjectivesIn order to accurately assess the ultimate load-bearing capacity of a hull structure under cyclic loading, it is necessary to consider the effects of the cyclic properties of the load on the ultimate strength of hull stiffened plates. MethodsFinite element software ANSYS is used to carry out the numerical simulation of ultimate strength based on the elastic shakedown limit state under in-plane cyclic loading for 200 T-bar stiffened plates and flat-bar stiffened plates. The material Bauschinger effect, welding initial deformation and residual stresses of the hull stiffened plates under in-plane cyclic loading are considered in detail. Based on the stiffened plate nonlinear finite element numerical simulation results of the elastic shakedown limit state, the dimensionless ultimate strength of the stiffened plates is taken as the objective function, the flexibility coefficients of the plates and stiffeners are taken as the independent variables, and a formula for predicting the ultimate strength of hull stiffened plates under in-plane cyclic loading based on the elastic shakedown limit state is proposed. ResultsThe accuracy of the formula is verified through comparison with the nonlinear finite element simulation results. ConclusionsThis study has positive theoretical and engineering significance for the ultimate strength assessment of hull stiffened plates under cyclic loading.

Abstract Background and Aim Gastric adenocarcinoma of the fundic gland type (GA‐FG) is a newly described tumor entity but lacking consensus. This review summarizes the key features and controversies regarding this uncommon neoplasm. Methods We reviewed studies on GA‐FG published in English from 2007 to 2021. Results We found that 327 cases (340 lesions) have been reported. GA‐FG lesions originate from deep layers of the gastric mucosa, with the following characteristics on conventional white‐light endoscopy examination. These lesions, macroscopically identified as submucosal tumor‐like 0‐IIa, tend to have a whitish discoloration without inflammation, atrophy, or intestinal metaplasia in the background mucosa. Tumors located in the upper third of the stomach are usually solitary, with an average size

ObjectivesIn order to improve the accuracy of the ultimate strength evaluation of hull plates, this study carries out a nonlinear finite element numerical simulation of the ultimate strength of ship hull plates under cyclic loading based on the critical state of elastic shakedown. MethodsFinite element software ANSYS is used to primarily investigate the effects of elastic-perfectly plastic and cyclic-plastic Chaboche material models on the release of welding residual stress and ultimate strength of hull plates after reaching the critical state of elastic shakedown. ResultsThe results show that after the first cycle, the welding residual stress is basically released and tends to become stable after reaching the elastic shakedown state under cyclic loading, at which point the ultimate strength of the Chaboche model is greater than that of the elastic-perfectly plastic model. ConclusionsWhen performing the nonlinear finite element numerical simulation of the ultimate strength of ship hull plates under cyclic loading based on the critical state of elastic shakedown, it is necessary to select a material model that takes into account material hardening and the Bauschinger effect. The obtained results have a certain reference value for further research on the ultimate strength of hull structures under cyclic loading.

Abstract Colorectal cancer (CRC) is the third‐most common cancer around the world, accounting for approximately 10% of cancer‐related mortality. Deeper molecular understanding of colorectal carcinogenesis will provide evidences for identification of early diagnostic indicators and novel therapeutic strategies for CRC treatment. The p21cdc42/rac1‐activated kinase 5 (PAK5) has been reported to be involved in a variety of tumor‐promoting behaviors, whereas the underlying mechanisms of PAK5 in CRC progression are still obscure. Our current study revealed an upregulated expression of PAK5 in human CRC tissues as compared with normal adjacent biopsies, which was associated with tumor progression and metastasis. We further unraveled that inhibition of PAK5 was correlated with restrained proliferation, migration, and invasion of CRC cells in vitro and in vivo. Moreover, we showed an indispensable role of PAK5 in interacting with Cdc42 and Integrin β1, β3, thus, to facilitate the migration and invasion of CRC cells. Collectively, we pointed out a potential of PAK5 to serve as a novel therapeutic target in restricting CRC proliferation and metastasis. The uncovered mechanisms will deepen the comprehension with regard to the mechanisms of CRC progression, as well as providing new insights for therapeutic intervention in colorectal cancer.

Objective: To determine whether the effectiveness of core stability exercises correlates with the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis. Methods: Forty-two patients with degenerative lumbar spinal stenosis treated in the department of orthopedics of our hospital between May 2013 and January 2016 were included in the study. All the patients performed core stability exercises once daily for six weeks and the clinical outcomes were evaluated using Japanese Orthopaedic Association (JOA) score and self-reported walking capacity. The anteroposterior osseous spinal canal diameter was measured to evaluate the severity of spinal stenosis. The correlation between the stenosis degree and the differences of Japanese Orthopaedic Association score or self-reported walking capacity at baseline and after treatment were analyzed. Results: The patients were divided into three groups according to the spinal stenosis degree. In the three groups, there was no significant difference in JOA or self-reported walking distance at baseline (p>0.05) and after treatment (p>0.05). The JOA scores and self-reported walking distance were significantly increased after treatment (p<0.05) in any of the three groups when compared to the baseline. Also, there was no significant correlation between the stenosis degree and the difference of JOA (p>0.05) or self-reported walking distance (p>0.05). Conclusion: There was no significant correlation between the effectiveness of core stability exercises and the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis. [ABSTRACT FROM AUTHOR]

Objective: To determine whether the effectiveness of core stability exercises correlates with the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis., Methods: Forty-two patients with degenerative lumbar spinal stenosis treated in the department of orthopedics of our hospital between May 2013 and January 2016 were included in the study. All the patients performed core stability exercises once daily for six weeks, and the clinical outcomes were evaluated using Japanese Orthopaedic Association (JOA) score and self-reported walking capacity. The anteroposterior osseous spinal canal diameter was measured to evaluate the severity of spinal stenosis. The correlation between the stenosis degree and the differences of Japanese Orthopaedic Association score or self-reported walking capacity at baseline and after treatment were analyzed., Results: The patients were divided into three groups according to the spinal stenosis degree. In the three groups, there was no significant difference in JOA or self-reported walking distance at baseline (p>0.05) and after treatment (p>0.05). The JOA scores and self-reported walking distance were significantly increased after treatment (p<0.05) in any of the three groups when compared to the baseline. Also, there was no significant correlation between the stenosis degree and the difference of JOA (p>0.05) or self-reported walking distance (p>0.05)., Conclusion: There was no significantcorrelation between the effectiveness of core stability exercises and the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis.