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This study examined the concurrent validity of a tummy time questionnaire and time-use diary against an accelerometer measure. Participants were 29 parents and their 6-month-old infants from the Early Movers project in Edmonton, Canada. Tummy time was concurrently measured using a parental questionnaire, a time-use diary, and a validated GENEActiv accelerometer. In participants with data on all measures (n = 26), relative (Spearman's rank correlations) and absolute (Wilcoxon signed-rank tests and Bland-Altman plots) concurrent validity were examined. The questionnaire (r[subscript s] = 0.60) and time-use diary (r[subscript s] = 0.80) tummy time measures were significantly correlated with the accelerometer measure, with large effect sizes (r > 0.50). Compared to the accelerometer measure of tummy time, a significant difference in mean rank was observed for the questionnaire measure but not for the time-use diary measure. Bland--Altman plots showed a significant mean difference in tummy time between the accelerometer and questionnaire measures (42 min/d; 95% limits of agreement: -73,157 min/d) but not between the accelerometer and time-use diary measures (2 min/d; 95% limits of agreement: -47,51 min/d). These preliminary findings indicate both subjective measures may be appropriate for infant studies examining associations with tummy time and/or comparing tummy time between samples. The time-use diary may also provide a relatively precise estimate of tummy time in prevalence studies.

Background: Child care centers are important for children's behaviors. Aims: To examine the cross-sectional associations between child care environmental characteristics and physical activity and sedentary time in children. Methods: Participants were 124 toddlers and 118 preschoolers from 19 centers in Alberta and Ontario, Canada, in the supporting Healthy physical AcTive CHildcare setting (HATCH) study. In-care physical activity and sedentary time were assessed using Actigraph accelerometers. Child care environments, including structure (e.g., resources) and process (e.g., activities) quality, were measured using three instruments: (1) the Environment and Policy Assessment and Observation and (2) the Children's Physical Environments Rating Scale, and (iii) the Movement Environment Rating Scale. Mixed models were performed to examine the associations between environmental characteristics and children's sedentary time, light physical activity, and moderate-to-vigorous physical activity. Results: A few structure quality characteristics related to child care policy and indoor environment were associated with higher physical activity and lower sedentary time in toddlers. The overall structure quality (B = 0.04; 95% CI [0.003, 0.08]) and process quality (B = 0.08; 95% CI [0.02, 0.15]) of the child care environment were associated with log moderate-to-vigorous physical activity in preschoolers. Specifically, structure quality characteristics of the outdoor environment and physical activity time, and process quality characteristics relevant to curriculum and pedagogy, were associated with higher physical activity and lower sedentary time in preschoolers. Discussion and Conclusion: The child care structure quality characteristics that are important for children' physical activity and sedentary behavior may vary by age group. Improving the overall process quality, in particular curriculum and pedagogy, of the child care environment, may promote more physical activity in preschoolers.

Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed impaired autophagy in IVDD-NPCs, which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype (SASP). The dysregulated SASP disrupted NPCs viability and initiated extracellular matrix degradation. Conversely, the restoration of autophagy reversed the senescence phenotype by inhibiting GATA binding protein 4 (GATA4). Moreover, we made the novel observation that a cross-talk between histone H3 lysine 4 trimethylation (H3K4me3) modification and N6-methyladenosine(m6A)-methylated modification regulates autophagy in IVDD-NPCs. Mechanistically, lysine methyltransferase 2A (KMT2A) promoted the expression of methyltransferase-like 3 (METTL3) through H3K4me3 modification, whereas METTL3-mediated m6A modification reduced the expression of autophagy-associated 4a (ATG4a) by attenuating its RNA stability, leading to autophagy damage in NPCs. Silencing KMT2A and METTL3 enhanced autophagic flux and suppressed SASP expression in IVDD-NPCs. Therefore, targeting the H3K4me3-regulated METTL3/ATG4a/GATA4 axis may represent a promising new therapeutic strategy for IVDD. [ABSTRACT FROM AUTHOR]

With the rapid development of Internet technology, the channels for the public to participate in forest protection and ecological construction have been expanded. In China, virtual forest realization projects have successfully heightened environmental awareness among the public. However, these projects have also faced a "green gap", characterized by a substantial disconnect between environmental intentions and actual participation behaviors. Based on 69 articles about virtual forest realization projects in China, this paper aims to reveal the roots of the intention–behavior gap, influencing factors, and potential mitigation strategies. Our findings indicate the following: (1) While virtual forest realization initiatives have made progress, they still face multiple challenges such as governmental inefficiencies and platform traffic bottlenecks. (2) The factors influencing public participation in virtual forest realization projects can generally be categorized into three types: external situational factors, internal psychological factors, and demographic variables. Initially, external influences like online word-of-mouth and gamified platforms played a crucial role in attracting the public. Over time, internal factors such as public trust in the platform and perceived enjoyment have become more prominent. Inconsistent findings regarding demographic variables suggest a need for further research. (3) Current solutions primarily focus on macro policies and have not fully addressed existing challenges. This study reveals the reasons and influencing factors of the intention–behavior gap, with the goal of offering valuable insights for future public engagement and project optimization. [ABSTRACT FROM AUTHOR]

This paper investigates a chemotaxis system with sublinear consumption of chemoattractant$\begin{align*} \begin{cases} u_t = \Delta u-\nabla \cdot(u \nabla v), \\ v_t = \Delta v-u v^m \end{cases} \end{align*} $under homogeneous Neumann boundary conditions in bounded convex domain $ \Omega \subset \mathbb{R}^3 $ with smooth boundary. We prove that if $ m \in (0, 1] $, for arbitrarily large initial data, then the model ($\star$) admits at least one global weak solution for which there exists $ T>0 $ such that $ (u, v) $ is bounded and smooth in $ {\Omega} \times(T, \infty) $. Moreover, it is asserted that such solutions are seen to stabilize toward spatially constant equilibrium in the large time limit. [ABSTRACT FROM AUTHOR]

In this work, we study the no-flux initial-boundary value problem for the migration-consumption taxis system involving singular density-suppressed motility u t = Δ (u l ϕ (v)) , v t = Δ v − u v m (⋆) in a bounded domain Ω ⊂ ℝ n (n ≥ 2) , where ϕ generalizes the singular prototype given by ϕ (ξ) = ξ − α (ξ > 0) with α > 0. We prove that if l > n 2 and m ≥ 1 , then the model (⋆) possesses a global weak-strong solution. [ABSTRACT FROM AUTHOR]