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In recent years, the combined surgery of phacoemulsification, intraocular lens implantation, and goniosychialysis has gradually emerged as a primary and effective approach in treating primary angle-closure glaucoma with cataracts. However, with the continuous progress of medical technology, postoperative intraocular pressure control is no longer the sole pursuit. Patients increasingly aspire to achieve higher postoperative visual quality. In order to ensure that patients attain a better refractive status and higher visual quality postoperatively, it is essential to minimize the negative impact caused by primary angle-closure glaucoma. This involves personalized selection of different intraocular lenses or calculation formulas,etc. Evaluation metrics for visual quality encompass visual acuity, contrast sensitivity, higher-order aberrations, subjective perception, etc. Therefore, this paper provides a comprehensive review of postoperative refractive shift, higher-order aberrations, contrast sensitivity and their influencing factors, and the selection of intraocular lenses for patients undergoing combined surgery for primary angle-closure glaucoma with cataracts.

Abstract Background The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify that DIO3OS can be used as a potential diagnostic biomarker and immunotherapeutic target. Methods The expression matrix data and clinical information were obtained from XENA platform of UCSC and GEO database as the test cohorts. The external validation cohort was collected from our hospital. Bioinformatics analysis was used to annotate the biological function of DIO3OS. Immune infiltration and immune checkpoint analysis were applied to evaluate whether DIO3OS can be used as an immunotherapeutic target. ROC curves and AUC were established to assess the diagnostic value of DIO3OS for differentiating patients from other subtypes sarcoma. The expression analysis was detected by qRT-PCR, western blot, and immunohistochemical. Wound healing assay and Transwell assay were applied to determine the migration and invasion function of DIO3OS in osteosarcoma cell lines. The tail vein injection osteosarcoma cells metastases model was used in this research. Results High expression of DIO3OS was identified as a risk lincRNA for predicting overall survival of osteosarcoma in test cohort. The outcomes of experiments in vitro and in vivo showed that low expression of DIO3OS limited osteosarcoma tumor metastasis with inhibiting TGF-β signaling pathway. Immune checkpoint genes (CD200 and TNFRSF25) expressions were inhibited in the low DIO3OS expression group. The DIO3OS expression can be applied to reliably distinguish osteosarcoma from lipomatous neoplasms, myomatous neoplasms, nerve sheath tumors, and synovial-like neoplasms. This result was further validated in the validation cohort. Conclusions In conclusion, our outcomes indicated that DIO3OS is a potential diagnostic and prognostic biomarker of osteosarcoma, emphasizing its potential as a target of immunotherapy to improve the treatment of osteosarcoma through TGF-β signaling pathway. Trial registration number: The present retrospectively study was approved by the Ethics Committee of The Second Affiliated Hospital of Nanchang University [Review (2020) No. (115)].

The formulations and approximations of the branch flow model for general (radial and mesh) power networks (General-BranchFlow) are given in this paper. Using different sets of the power flow equations, six formats of the exact General-BranchFlow model are listed. The six formats are mathematically equivalent with each other. Linear approximation and second-order cone programming (SOCP) are then used to derive the six formats of the convex General-BranchFlow model. The branch ampacity constraints considering the shunt conductance and capacitance of the transmission line $\Pi$-model are derived. The key foundation of deriving the ampacity constraints is the correct interpretation of the physical meaning of the transmission line II-model. An exact linear expression of the ampacity constraints of the power loss variable is derived. The applications of the General-BranchFlow model in deriving twelve formats of the exact optimal power flow (OPF) model and twelve formats of the approximate OPF model are formulated and analyzed. Using the Julia programming language, the extensive numerical investigations of all formats of the OPF models show the accuracy and computational efficiency of the General-BranchFlow model. A penalty function based approximation gap reduction method is finally proposed and numerically validated to improve the AC-feasibility of the approximate General-BranchFlow model.

Abstract Targeted kinase inhibitors improve the prognosis of lung cancer patients with ALK alterations (ALK+). However, due to the emergence of acquired resistance and varied clinical trajectories, early detection of disease progression is warranted to guide patient management and therapy decisions. We utilized 343 longitudinal plasma DNA samples from 43 ALK+ NSCLC patients receiving ALK-directed therapies to determine molecular progression based on matched panel-based targeted next-generation sequencing (tNGS), and shallow whole-genome sequencing (sWGS). ALK-related alterations were detected in 22 out of 43 (51%) patients. Among 343 longitudinal plasma samples analyzed, 174 (51%) were ctDNA-positive. ALK variant and fusion kinetics generally reflected the disease course. Evidence for early molecular progression was observed in 19 patients (44%). Detection of ctDNA at therapy baseline indicated shorter times to progression compared to cases without mutations at baseline. In patients who succumbed to the disease, ctDNA levels were highly elevated towards the end of life. Our results demonstrate the potential utility of these NGS assays in the clinical management of ALK+ NSCLC.

In this study, the impact of varying spraying current on tribological performance and microstructural properties for coating was investigated. Atmospheric plasma spraying (APS) was used as the technique of depositing coatings on Q235 grade steel (equivalent to ASTM A36 mild steel). The coated samples were characterized using optical microscopy (OM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), adhesion testers and microhardness tester. Scratch tests were carried out under ambient and dry environments using a pin-on-plate configuration against Tungsten Carbide (WC) body (pin/stylus) for a constant load. It was found that samples sprayed under higher current had better adhesive bond and erosion wear resistance, they also had the lowest wear loss and least percentage porosity. Additionally, hardness was improved almost 10 times of the base material in comparison to lower current samples. Resumen: En este estudio se investigó el impacto de la corriente de pulverización variable sobre el rendimiento tribológico y las propiedades microestructurales para el recubrimiento del Cr2O3. La pulverización con plasma atmosférico (PPA) se usó como la técnica para depositar recubrimientos de Cr2O3 sobre acero de grado Q235 (equivalente al acero dulce ASTM A36). Las muestras recubiertas se caracterizaron usando microscopía óptica (MO), microscopía electrónica de barrido (MEB), espectroscopia de energía dispersiva (EED), probadores de adherencia y probadores de microdureza. Las pruebas se llevaron a cabo en medios ambientales y secos utilizando una configuración de pin en placa contra el cuerpo de carburo de tungsteno (WC) (pin/stylus) para una carga constante. Se encontró que las muestras rociadas con una corriente más alta tenían un mejor enlace adhesivo y una mejor resistencia al desgaste por erosión, también tenían menor pérdida de desgaste y menor porcentaje de porosidad. Además, se mejoró la dureza casi 10 veces del material base en comparación con muestras de corriente más baja.

This paper informs the design guidelines, fabrication process, and evaluation of a 1.7-kV and 300-A multi-chip half bridge power module using the novel Si-IGBT and SiC-MOSFET hybrid switch in each switch position. The module achieves its maximum DC current rating with a 6:1 current ratio of Si to SiC. This high current ratio yields significant cost savings compared to an all-SiC power module. The module employs high-reliability silver clips, which replaces conventional wire bonds for top-side interconnection, to partly enable a low power loop inductance of 12.38 nH. A novel thermal pyrolytic graphite-encapsulated metal baseplate is key to reducing the thermal coupling among the adjacent Si and SiC die, enabling higher junction temperature for SiC die relative to the Si die.

Polyimide is often used as the insulating material of the repulsion coil, which needs to withstand the collision of the fast repulsion mechanism in high-speed motion and temperature rise. The polyimide molecular model was established in this study. The external electric field was applied to the model through the semi-empirical method to calculate the total molecular energy, dipole moment, molecular orbital energy, and energy gap of polyimide. It was found that the total molecular energy of plasma-modified polyimide was lower, the energy gap was smaller, and the corresponding molecular properties were more stable. Then, the cell models of ordinary polyimide and plasma-modified polyimide were established by molecular dynamics simulation. The effects of plasma modification on the micro properties of polyimide were studied and compared. The free volume, mean square displacement, cohesive energy density, mechanical properties, and relative dielectric constant of polyimide models with different modified ratios were calculated. The results show that the introduction of polar groups through plasma modification can inhibit the movement of the polyimide molecular chain and improve the thermal stability of the polyimide system. The mechanical properties of polyimide are also improved due to plasma modification, and the elastic modulus is the largest when the modification rate is 20%. At the same time, the relative dielectric constant of polyimide increases with the increase of the modification rate.

Morchella is a genus of fungi with the ability to concentrate Cd both in the fruit-body and mycelium. However, the molecular mechanisms conferring resistance to Cd stress in Morchella are unknown. Here, RNA-based transcriptomic sequencing was used to identify the genes and pathways involved in Cd tolerance in Morchella spongiola. 7444 differentially expressed genes (DEGs) were identified by cultivating M. spongiola in media containing 0.15, 0.90, or 1.50 mg/L Cd2+. The DEGs were divided into six sub-clusters based on their global expression profiles. GO enrichment analysis indicated that numerous DEGs were associated with catalytic activity, cell cycle control, and the ribosome. KEGG enrichment analysis showed that the main pathways under Cd stress were MAPK signaling, oxidative phosphorylation, pyruvate metabolism, and propanoate metabolism. In addition, several DEGs encoding ion transporters, enzymatic/non-enzymatic antioxidants, and transcription factors were identified. Based on these results, a preliminary gene regulatory network was firstly proposed to illustrate the molecular mechanisms of Cd detoxification in M. spongiola. These results provide valuable insights into the Cd tolerance mechanism of M. spongiola and constitute a robust foundation for further studies on detoxification mechanisms in macrofungi that could potentially lead to the development of new and improved fungal bioremediation strategies.

Abstract The direct‐current circuit breaker (DCCB) is the most ideal choice for DC fault isolation in DC grids. Despite a late start, China's research and development on the DCCB have made outstanding achievements. This article provides a brief glance of current China's DCCB development status. It begins by sorting out the technical route according to the topology of DCCB. Then it systematically summarises both mechanical and hybrid DCCBs with focussing on the aspects of topology structure and principle, key technology and characteristics, prototype development and application. It is apparent that Chinese scientists and engineers confronted the worldwide problem of large capacity DC breaking, and put forward a comprehensive solution which consists of an innovative topology structure based on coupled negative voltage circuit, breaking throughs on the key technologies such as highly controllable and reliable fault current commutation, millisecond‐level ultra‐fast and efficient electromagnetic repulsion mechanism, high tolerance and high stability power electronic switch, low residual voltage and fast response energy consumption device, etc. The article states that the world's first set of hybrid high‐voltage (HV) DCCB, and the first set of mechanical HV DCCB have been developed. These DCCBs will soon be deployed to the DC grids which have the highest voltage levels therefore require the strongest breaking capacity. These achievements are leading the world in the development and application of DCCB. The article also discusses the overall development trends of DCCB in the areas of new topologies, key technological breakthroughs and application scenarios, etc. These discussions serve as references for DCCB's future technological advancement and its ever‐expanding applications.

The DC solid state circuit breaker (SSCB) is the key equipment to construct the DC distribution network. In this paper, an improved topological scheme of RC buffer and metal oxide arrester (MOA) in parallel is proposed, which can not only improve the capacity of circuit breaker to cut off large current, but also reduce the pressure of MOA absorbing energy and shorten the time of fault clearing. A 10kV DC SSCB is designed based on the proposed topology, and a model of the influence of different RC buffer parameters on MOA and DC SSCB is built in PSCAD. The simulation results show that the energy absorbed by MOA is linearly decreasing with buffer capacitance Csand total inductance L of the system. As the buffer resistance Rsincreases, the energy absorbed by the MOA decreases first and then increases. Too small snubber resistance will cause the DC SSCB breaking overvoltage and fault current to oscillate; excessive snubber capacitor will cause the DC SSCB breaking overvoltage to be too high. Therefore, it is necessary to select the optimal RC parameters under different fault currents, which can not only reduce the pressure of MOA, but also improve the shutdown capability of DC SSCB.

The flexible DC transmission system needs a DC circuit breaker to remove and isolate the bipolar short-circuit fault to prevent the excessive short-circuit current from damaging the DC transmission system. In this paper, a comprehensive model of DC circuit breaker and transmission system is established by using PSCAD based on capacitive buffered hybrid DC circuit breaker. The short-circuit current waveform and DC port voltage waveform of the three-terminal ±350 kV flexible DC transmission system under the condition of double-pole short-circuit fault at the DC side of rectifier station are simulated and calculated. The simulation results show that the maximum current and voltage of the capacitor-buffering hybrid DC circuit breaker model is lower than that of the ideal DC circuit breaker model under the condition of bipolar short-circuit fault at the DC side of the rectifier station. The system fault waveform under different parameters of capacitor-buffered hybrid DC circuit breaker is compared and analyzed through simulation, so as to optimize the parameters of circuit breaker. It can be seen that the actual results more in line with the switching process can be obtained by using the capacitor buffer type hybrid DC circuit breaker.

A novel magnetic fluid was obtained using a colloidal dispersion of amorphous magnetic Fe-Ni-B nanoparticles into water. Its magnetorheological and viscoelastic behaviors were all investigated. Results showed that the generated particles were spherical amorphous particles 12–15 nm in diameter. The saturation magnetization of Fe-based amorphous magnetic particles could reach 49.3 emu/g. The amorphous magnetic fluid exhibited shear shinning behavior under magnetic fields and showed strong magnetic responsiveness. The yield stress increased with the rising magnetic field strength. A crossover phenomenon was observed from the modulus strain curves due to the phase transition under applied magnetic fields. The storage modulus G′ was higher than the loss modulus G″ at low strains, while G′ was lower than G″ at high strains. The crossover points shifted to higher strains with increasing magnetic field. Furthermore, G′ decreased and fell off in a power law relationship when the strain exceeded a critical value. However, G″ showed a distinct maximum at a critical strain, and then decreased in a power law fashion. The magnetorheological and viscoelastic behaviors were found to be related to the structural formation and destruction in the magnetic fluids, which is a joint effect of magnetic fields and shear flows.

To achieve the established carbon emission reduction targets, reduce the intensity of carbon leakage, and protect the EU local enterprise market, in December 2022, the amendment to the EU Carbon Border Adjustment Mechanism (CBAM), which covers key industries such as steel, aluminum products, cement, fertilizer, and electricity, was officially released by the EU Parliament decision and will be officially implemented on October 1, 2023. This study tries to discuss its impact for China—EU trade.

Taking a commercial building in Shanghai as an example, a list of cooling and heating systems are established and operation strategies are formulated. Based on the precondition that the excess electricity can be sold to the grid, the primary energy utilization rate and economices of the energy supply schemes are analyzed. The results show that compared with the traditional heating and cooling supply method, the combined cooling, heating, and power systems have better energy-saving and economic benefits. Additionally, the inclusion of the thermal energy storage yields additional economic benefits (up to 36% reduction in the CO2eq emissions and up to the 21% reduction in the total annual cost). Under the following-electric-load operation mode, the role of the thermal energy storage is to alleviate the temporal mismatch between the electric demand and the heating or cooling demand. To be specific, in the combined cooling, heating, and power systems, the total annual cost is reduced by up to 5.8% and the annual carbon dioxide equivalent emissions are reduced by up to 2.4% when the thermal energy storage is used. While under the following-electric-price operation mode, the performance of the CCHP system is largely subject to the natural gas price. Last, although heat pump systems are often regarded as efficient systems owing to the relatively high coefficient of performance of the heat pump, the energy supply through the heat pump systems may be carbon-emission-intensive currently.

The gas-solid compatibility between environmentally friendly insulating gas and copper contacts is worth studying. In this paper, based on density functional theory, the adsorption calculation of CF3I, c-C4F8, five typical decomposition gases, and Cu (1 1 1) surface was carried out. The adsorption energies, transferred charges, charge densities, and densities of states were calculated for different adsorption configurations. Research indicates that there is no obvious charge transfer between the I atom and the Cu atom in the four adsorption sites of Cu (1 1 1) for the CF3I molecule. There is a charge transfer between the F atoms and the Cu top surface. The electrons lost by Cu are transferred to F atoms. In the configurations of different adsorption positions on CF3I and Cu (1 1 1) planes, the top and bridge adsorption energies are −0.835 eV and −0.993 eV, respectively, which are chemical adsorption. Therefore, CF3I is most likely to form adsorption at the top or bridge site of the Cu (1 1 1) surface. The adsorption energy of c-C4F8 gas on Cu (1 1 1) surface is similar to that of CF3I at fcc and hcp sites. The absolute values are all less than 0.8 eV, and the van der Waals force is the main force. The adsorption energies of C2F4 and C3F6 in the five decomposed gases are −1.315 eV and −1.204 eV, respectively. The charge transfer is −0.32 eV and −0.45 eV, respectively. Their values are larger than those of the other gases studied, which belong to chemical adsorption. The smaller values of the remaining three gases belong to physical adsorption. All molecular structures and Cu (1 1 1) planes were not significantly deformed. From a microscopic point of view, the gas can better exist on the copper surface.

With the increase of short circuit current, measures should be taken to reduce the impact. Among various measures, a new technique to interrupt or limit current is proposed and applied to power grid based on high coupled split reactor (HCSR). As the key equipment in new technique, the insulation design of HCSR is a priority. Previous works mainly involve voltage across HCSR in different working states, and take the whole voltages as design requirements. It is rough and takes no account of voltage distribution inside HCSR, thus not suitable for insulation design of HCSR. In order to analyze the overvoltage problems and determine insulation demands for HCSR, this article establishes the equivalent circuit model in turn unit to calculate the voltage distribution inside HCSR, which is simplified and accurate enough for HCSR. A 500 kV AC fault current limiter is briefly introduced, and voltages between turns or arms in HCSR are obtained. The voltage between turns are evenly distributed and voltage between arms are very low under switching impulse. As for lightning impulse, maximum turn-to-turn voltages mainly appear in the end of encapsulations, and the voltage between arms in current sharing state is considerable. This article gives the calculation method and general rules of voltage distribution inside HCSR, and it has great significance for the insulation design of HCSR.

BackgroundG protein subunit gamma 12 (GNG12) is observed in some types of cancer, but its role in osteosarcoma is unknown. This study hypothesized that GNG12 may be a potential biomarker and therapeutic target. We aimed to identify an association between GNG12 and osteosarcoma based on the Gene Expression Omnibus and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) databases.MethodsOsteosarcoma samples in GSE42352 and TARGET database were selected as the test cohorts. As the external validation cohort, 78 osteosarcoma specimens from The Second Affiliated Hospital of Nanchang University were collected. Patients with osteosarcoma were divided into high and low GNG12 mRNA-expression groups; differentially expressed genes were identified as GNG12-related genes. The biological function of GNG12 was annotated using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment analysis, and immune infiltration analysis. Gene expression correlation analysis and competing endogenous RNA regulatory network construction were used to determine potential biological regulatory relationships of GNG12. Overall survival, Kaplan–Meier analysis, and log-rank tests were calculated to determine GNG12 reliability in predicting survival prognosis.ResultsGNG12 expression decreased in osteosarcoma samples. GNG12 was a highly effective biomarker for osteosarcoma [area under the receiver operating characteristic (ROC) curve (AUC) = 0.920], and the results of our Kaplan–Meier analysis indicated that overall survival and progression-free survival differed significantly between low and high GNG-expression group (p < 0.05). Functional analyses indicated that GNG12 may promote osteosarcoma through regulating the endoplasmic reticulum. Expression correlation analysis and competing endogenous RNA network construction showed that HOTTIP/miR-27a-3p may regulate GNG12 expression. Furthermore, the subunit suppresses adaptive immunity via inhibiting M1 and M2 macrophage infiltration. GNG12 was inhibited in metastatic osteosarcoma compared with non-metastatic osteosarcoma, and its expression predicted survival of patients (1, 3, and 5-year AUCs were 0.961, 0.826, and 0.808, respectively).ConclusionThis study identified GNG12 as a potential biomarker for osteosarcoma prognosis, highlighting its potential as an immunotherapy target.

In this paper, in accordance with the breaker requirements of a parallel-type circuit breaker based on a high-coupling split reactor, the structure of a coupling reactor is proposed, and the influences of the inner radius, encapsulation height, air ducts width, and encapsulation number of the reactor on coupling factor is analyzed. The reactor design is optimized to minimize metal conductor usage, and the initial design parameters of the coupling reactor are selected based on equal height and heat flux of the coaxial encapsulations. Meanwhile, combined thermal and electromagnetic optimization method and heat load optimization are adopted considering a single-arm limiting current and two-arm flow current working conditions. The optimization results show that the metal conductor usage of the coupling reactor is only 63% compared to a design based on the initial design parameters, and the correctness of the optimization is verified by simulation results.

Abstract Optimal power flow (OPF) is the fundamental mathematical model to optimize power system operations. Based on conic relaxation, Taylor series expansion and McCormick envelope, we propose three convex OPF models to improve the performance of the second-order cone alternating current OPF (SOC-ACOPF) model. The underlying idea of the proposed SOC-ACOPF models is to drop assumptions of the original SOC-ACOPF model by convex relaxation and approximation methods. A heuristic algorithm to recover feasible ACOPF solution from the relaxed solution of the proposed SOC-ACOPF models is developed. The proposed SOC-ACOPF models are examined through IEEE case studies under various load scenarios and power network congestions. The quality of solutions from the proposed SOC-ACOPF models is evaluated using MATPOWER (local optimality) and LINDOGLOBAL (global optimality). We also compare numerically the proposed SOC-ACOPF models with other two convex ACOPF models in the literature. The numerical results show robust performance of the proposed SOC-ACOPF models and the feasible solution recovery algorithm.

The contact is the core element of the vacuum interrupter of the mechanical DC circuit breaker. The electrical conductivity and welding resistance of the material directly affect its stability and reliability. AgSnO2 contact material has low resistivity, welding resistance, and so on. This material occupies an important position of the circuit breaker contact material. This research is based on the first-principles analysis method of density functional theory. The article calculated the lattice constant, enthalpy change, energy band, electronic density of state, charge density distribution, population, and conductivity of Ce, C single-doped, and Ce-C codoped SnO2 systems. The results show that Ce, C single doping, and Ce-C codoping all increase the cell volume and lattice constant. When the elements are codoped, the enthalpy change is the largest, and the thermal stability is the best. It has the smallest bandgap, the most impurity energy levels, and the least energy required for electronic transitions. The 4f orbital electrons of the Ce atom and the 2p orbital electrons of C are the sources of impurity energy near the Fermi level. When the elements are codoped, more impurity energy levels are generated at the bottom of the conduction band and the top of the valence band. Its bandgap is reduced so conductivity is improved. From the charge density and population analysis, the number of free electrons of Ce atoms and C atoms is redistributed after codoping. It forms a Ce-C covalent bond to further increase the degree of commonality of electrons and enhance the metallicity. The conductivity analysis shows that both single-doped and codoped conductivity have been improved. When the elements are codoped, the conductivity is the largest, and the conductivity is the best.

Background: Targeted therapies (TKI) have improved the prognosis of ALK-rearranged lung cancer (ALK+ NSCLC), but clinical courses vary widely. Early identification and molecular characterisation of treatment failure have key importance for subsequent therapies. We performed copy number variation (CNV) profiling and targeted panel sequencing from cell-free DNA (cfDNA) to monitor ALK+ NSCLC. Methods: 271 longitudinal plasma DNA samples from 73 patients with TKI-treated metastatic ALK+ NSCLC were analysed by capture-based targeted (average coverage 4,100x), and shallow whole genome sequencing (sWGS, 0.5x). Mutations were called using standard algorithms. CNVs were quantified using the trimmed median absolute deviation from copy number neutrality (t-MAD). Findings: cfDNA mutations were identified in 58% of patients. They included several potentially actionable alterations, e.g. in the genes BRAF, ERBB2, and KIT. sWGS detected CNVs in 18% of samples, compared to 6% using targeted sequencing. Several of the CNVs included potentially druggable targets, such as regions harboring EGFR, ERBB2, and MET. Circulating tumour DNA (ctDNA) mutations and t-MAD scores increased during treatment, correlated with markers of higher molecular risk, such as the EML4-ALK variant 3 and/or TP53 mutations, and were associated with shorter patient survival. Importantly, t-MAD scores reflected the tumour remission status in serial samples similar to mutant ctDNA allele frequencies, and increased with disease progression in 79% (34/43) of cases, including those without detectable single nucleotide variant (SNV). Interpretation: Combined copy number and targeted mutation profiling could improve monitoring of ALK+ NSCLC. Potential advantages include the identification of treatment failure, in particular for patients without detectable mutations, and broader detection of genomic changes acquired during therapy, especially in later treatment lines and in high-risk patients. Funding: This work was supported by the German Center for Lung Research (DZL), by the German Cancer Consortium (DKTK), by the Heidelberg Center for Personalized Oncology at the German Cancer Research Center (DKFZ-HIPO), and by Roche Sequencing Solutions (Pleasanton, CA, USA).

In order to study the transient characteristics of a nuclear reactor coolant pump in coast-down process under power failure condition, a transient test device for the nuclear reactor coolant pump is set up. This study investigates the effects of the rotor of the nuclear reactor coolant pump and the circuit characteristics on the nuclear reactor coolant pump during the coast-down process by changing the rotary inertia of the flywheel and the resistance of the pipe system. The results show that the greater the moment of inertia is, the more slowly rotational speed, flow, and lift get down in the same coast-down period. The change in the pipe resistance has little effect on the rate of decline in the coast-down process, but it has a great influence on the descent speed of the flow rate and lift. When the pipe resistance is small, the corresponding flow rate decreases faster, but it is slower for the corresponding lift. The results are of great significance in controlling the stability and reliability of the nuclear reactor coolant pump in the coast-down process.

The true bipolar modular multilevel converter-based multi-terminal direct current (MMC-MTDC) DC transmission line is prone to single-pole grounding fault, which may cause overload and overcurrent of the non-fault DC line with fault poles, resulting in system protection misoperation and system collapse. Therefore, the power transfer control strategy should be adopted to improve system stability. In addition, considering that the commutator stations of true bipolar MMC-MTDC system may have unipolar faults, it is necessary to adopt the control strategy of inter-pole power transfer or inter-station power transfer to improve the transmission capacity of the system under fault conditions. In this paper, a power transfer control strategy is proposed, which is widely applicable to MMC-MTDC system. In the case of line fault, the power transfer takes into account the line power margin and the power margin of converter station. The inter-pole power transfer is better than the inter-station power transfer under the converter station fault condition, and the inter-station power transfer takes into account the priority of the power margin of the converter station. At the same time, based on the Zhangbei four-terminal flexible direct current transmission project, the Zhangbei four-terminal flexible direct current transmission system is built by using PSCAD/EMTDC, and the flexibility and effectiveness of the proposed strategy are verified by simulation.

The purpose of this study was to evaluate the incidence rate of post-stroke upper limb spasticity and its correlation with cerebral infarction site.

Low-dimensional systems exhibit unique optical properties. Yuanet al. demonstrate one-dimensional organic-inorganic hybrid metal halide perovskites with highly efficient bluish white-light emission due to efficient exciton self-trapping in the quantum-confined structure.

Recently, there has been significant interest in developing the modular multilevel converter (MMC) based DC grids in the power industry. However, the immature DC circuit breaker (DCCB) technology hampers the development of DC grids in overhead lines transmission field. The full controlled power electronic devices based hybrid DCCB has been proposed and researched substantially. But the hybrid type DCCB suffers from the drawback of high cost and low reliability, leading to high capital cost for DC grids that require numerous DCCBs. In this paper, a mechanical type DCCB, consisting of a mechanical switch, a circuit and an oscillation circuit, is proposed. Then, a four-terminal bipolar MMC-HVDC system implementing the mechanical DCCBs is studied. Extensive simulations have been conducted to analyse the transient performance under different fault conditions. The simulation results verify the technical feasibility of this mechanical DCCB in DC grid.

The ionized field should be controlled in order to insure the environmental friendliness of high voltage direct current (HVDC) transmission lines. Different with traditional HVDC transmission lines, the metal return lines is first employed in Zhangbei ±500kV flexible HVDC lines. In this paper, the characteristics of ionized field with and without metal return lines are calculated on the basis of numerical method with Deutsch’s assumption. The influence factors, i.e. roughness coefficient, distance between metal return line and height of the metal return line, are analysed in detail. The results show that the metal return lines will have a shield effect on the ionized field on the ground. The distribution of ionized field is nearly independent on the height of metal return line. The shielding effect of the metal return line mainly contributes to the projection position of the metal return line. The presented results can give instructions for the design and control of the ionized field level of flexible HVDC lines with metal return lines.