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359 results on '"Zheng, Jiaqi"'

14. Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice

Author

Hu Jiajia, Yang Ziyao, Zheng Jiaqi, Chen Yanli, Zhao Xiaotao, and Su Ming

Subjects
Ufm1, UFMylation, Cardiac hypertrophy, Tnfaip2, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract UFMylation is a ubiquitination-like modification that is related to endoplasmic reticulum stress and unfolded protein response. A recent study reported that Ufl1, a key enzyme of UFMylation, protects against heart failure, indicating that UFMylation may be associated with heart function regulation. In the present study, we initially constructed a Flag-6×His-tagged Ufm1ΔSC transgenic (Tg-Ufm1) mouse model that enables UFMylation studies in vivo. Tg-Ufm1 mice showed significant activation of UFMylation in hearts. By using this model, we identified 38 potential Ufm1-binding proteins in heart tissues through LC‒MS/MS methods. We found that these proteins were associated with mitochondria, metabolism and chaperone binding. By using transcriptomic screening, we identified Tnfaip2 as a novel UFMylation-associated gene. Overexpression of Ufm1 significantly upregulated the protein expression of Tnfaip2, whereas isoproterenol treatment decreased Tnfaip2 expression in Tg-Ufm1 mice. These data may provide novel clues for UFMylation in cardiac hypertrophy.

Published
2023
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23. Incidence, process of care, and outcomes of out-of-hospital cardiac arrest in China: a prospective study of the BASIC-OHCA registry

Author

Zheng, Jiaqi, Lv, Chuanzhu, Zheng, Wen, Zhang, Guoqiang, Tan, Huiqiong, Ma, Yu, Zhu, Yimin, Li, Chaoqian, Han, Xiaotong, Yan, Shengtao, Pan, Chang, Zhang, Jianbo, Hou, Yaping, Wang, Chunyi, Bian, Yuan, Liu, Rugang, Cheng, Kai, Ma, Jingjing, Zheng, Zhaolei, Song, Ruixue, Wang, Mingjie, Gu, Jianhua, McNally, Bryan, Ong, Marcus Eng Hock, Chen, Yuguo, and Xu, Feng

Published
2023
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28. Fine and coarse particulate air pollution and out-of-hospital cardiac arrest onset: a nationwide case-crossover study in China

Author

Pan, Chang, Xu, Chang, Zheng, Jiaqi, Song, Ruixue, Lv, Chuanzhu, Zhang, Guoqiang, Tan, Huiqiong, Ma, Yu, Zhu, Yimin, Han, Xiaotong, Li, Chaoqian, Yan, Shengtao, Zheng, Wen, Wang, Chunyi, Zhang, Jianbo, Bian, Yuan, Ma, Jingjing, Cheng, Kai, Liu, Rugang, Hou, Yaping, Chen, Qiran, Zhao, Xiangkai, McNally, Bryan, Chen, Renjie, Kan, Haidong, Meng, Xia, Chen, Yuguo, and Xu, Feng

Published
2023
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31. The impact of non-optimum temperatures, heatwaves and cold spells on out-of-hospital cardiac arrest onset in a changing climate in China: a multi-center, time-stratified, case-crossover study

Author

Liu, Jiangdong, Lv, Chuanzhu, Zheng, Jiaqi, Pan, Chang, Zhang, Guoqiang, Tan, Huiqiong, Ma, Yu, Zhu, Yimin, Han, Xiaotong, Li, Chaoqian, Yan, Shengtao, Ma, Jingjing, Zhang, Jianbo, Wang, Chunyi, Bian, Yuan, Cheng, Kai, Liu, Rugang, Hou, Yaping, Chen, Qiran, Zhang, Xuan, Chen, Yuguo, Chen, Renjie, and Xu, Feng

Published
2023
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49. Prevalence and risk factors associated with circadian syndrome in community-dwelling middle-aged to older adults: Based on health ecology model.

Author

Liang, Haixu, Zheng, Jiaqi, and Sun, Yongkang

Subjects
*MIDDLE-aged persons, *ENVIRONMENTAL health, *OLDER people, *BASIC income, *SOCIAL isolation
Abstract

To explore the prevalence and risk factors associated with circadian syndrome (CricS) in community-dwelling middle-aged to older adults. We performed a cross-sectional analysis of 13,516 participants from the China Health and Retirement Longitudinal Study (CHARLS). We used logistic regression to compute the odds ratios (OR) and 95 % confidence intervals (Cls), using covariates derived through the health ecology model. The overall prevalence of CricS was 31.5 % (25.0 % males and 37.1 % females). With controlling all covariates, social isolation (OR 1.164, 95%CI 1.033–1.310), irritable mood (OR 1.689, 95%CI 1.488–1.917), fear responses (OR 1.546, 95%CI 1.262–1.894), chronic disease (OR 1.577, 95%CI 1.392–1.788), and financial debt (OR 0.806, 95%CI 0.657–0.990) were significantly correlated with increased CricS risk in males, whereas CricS syndrome was significantly associated with age (OR 1.285, 95%CI 1.214–1.361), married (OR 1.258, 95%CI 1.089–1.452), current drinkers (OR 0.835, 95%CI 0.716–0.974), social isolation (OR 1.175, 95%CI 1.065–1.296), irritable mood (OR 1.346, 95%CI 1.210–1.497), fear responses (OR 1.202, 95%CI 1.047–1.378), chronic disease (OR 1.363, 95%CI 1.225–1.517), chronic pain (OR 1.177, 95%CI 1.058–1.309), and universal basic income (OR 0.742, 95%CI 0.611–0.900) in females. CricS is common in middle-aged to older adults, and health behavior factors have an important impact on CricS. The potential predictors identified for CricS should be further studied to prevent the occurrence of adverse health events in the presenium stage. • Circadian syndrome is a major health problem around the world. • The prevalence of circadian syndrome in the present study was 31.5 %. • Circadian syndrome risk factors are multi-level, multi-dimensiona. [ABSTRACT FROM AUTHOR]

Published
2024
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