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Background: Left atrial appendage closure (LAAC) was effective in preventing thromboembolic events and stroke in patients with atrial fibrillation (AF). However, whether left atrial spontaneous echo contrast (LA-SEC) poses a higher risk for thromboembolism is contradictory. We aimed to investigate whether LA-SEC is a risk factor for thromboembolic events in patients who underwent LAAC. Methods: 258 consecutive patients who underwent successful LAAC were enrolled and divided according to the presence or absence of LA-SEC detected by transesophageal echocardiography (TEE). Propensity score matching (PSM) was used to eliminate covariate imbalances. Baseline characteristics, periprocedural details, and clinical outcomes were compared between LA-SEC and non-LA-SEC groups and PSM-matched groups. Results: Of the 258 patients enrolled, mean age was 71.8 ± 8.3 years and 59.3 % were male. LA-SEC group had a higher percentage of persistent AF and worse cardiac function. No significant difference in peri-procedure parameters was found. Through follow-up of 38.1 ± 10.7 months, the total incidence of thromboembolic events and stroke was 7.8 % and 6.6 %, respectively. Though the event-free survival rate of thromboembolic events (Log-Rank P = 0.042) and stroke (Log-Rank P = 0.010) was significantly lower in the LA-SEC group, multivariable COX regression analysis showed LA-SEC was not an independent predictor of thromboembolic events (Hazard ratio 2.073, 95 % Confidence interval 0.845–5.082, P = 0.111). Further survival analysis between PSM-matched groups with comparable baseline characteristics presented no significant difference in survival free from thromboembolic events (Log-Rank P = 0.616) and stroke (Log-Rank P = 0.312). Conclusion: Patients with LA-SEC had worse condition, while LA-SEC per se did not increase the incidence of thromboembolic events and stroke for patients who underwent LAAC.

Abstract Background The combined procedure of left atrial appendage closure (LAAC) with concomitant pulmonary vein isolation (PVI) has demonstrated its efficacy and safety. However, there is still a lack of comparative investigations regarding the long-term benefits of the combined procedure when compared to LAAC alone. Our study aims to assess the long-term outcomes of combined procedure of LAAC with concomitant PVI in comparison with a propensity matched LAAC alone group. Methods Propensity score matching (PSM) was employed to rectify covariate imbalances, resulting in the inclusion of 153 comparable patients from the initial cohort of 333 non-valvular atrial fibrillation (AF) patients. Clinical outcomes, encompassing thrombotic events, major cardiocerebrovascular adverse events (MACCE), re-hospitalization due to cardiovascular disease (CVD), and atrial tachycardia (AT), were juxtaposed between the two groups. Bleeding events and peri-device complications, such as residual flow, device-related thrombus, and device replacement, were also compared. Additionally, a patients group underwent PVI alone was included for comparing AF recurrence rates between the PVI alone group and the combined group. Results Following PSM, 153 patients (mean age 70.3 ± 8.9, 62.7% men) were included, with 102 undergoing the combined procedure and 51 undergoing LAAC alone. No significant differences were found in baseline characteristics between the two groups. The mean follow-up time was 37.6 ± 7.9 months, and two patients were lost to follow-up in the combined procedure group. Thrombotic events were observed in 4 (7.8%) patients in the LAAC alone group and 4 (4.0%) in the combined group (Log-rank p = 0.301). The proportion of patients experiencing MACCE, re-hospitalization due to CVD, and AT between the two groups was comparable, as were bleeding events and peri-device complications. Among patients from the combined procedure group without AF recurrence, a significant difference was noted in prior-procedure left ventricular ejection fraction (LVEF) and LVEF at the 12th month after the procedure (57.2% ± 7.1% vs. 60.5% ± 6.5%, p = 0.002). Conclusion The concomitant PVI and LAAC procedure did not increase procedure-related complications, nor did it confer significant benefits in preventing thrombotic events or reducing other cardiovascular events. However, the combined procedure improved heart function, suggesting potential long-term benefits.

School infiltration is an important aspect of family parenting research in recent years. This study reexamines the evaluation mechanism of higher education access path to explore the feelings of schooling winners (also Gaokao winners). Different from stratified education’s understanding of family authority, this study proposes to deconstruct the rough understanding of stratified type, presenting a more historical and life-sense process of education acquisition and family parenting mode permeated by school education. This paper mainly uses the method of narrative analysis to explore the family parenting experiences of eight successful participants in higher education. The study found that Chinese family parenting was heavily influenced by schooling. Through discipline, empathy, and home-school cooperation, families reinforce the ideals and goals of schooling (high scores) in the field outside the school. Thus, participants expressed negative views and feelings about teachers, classmates and families. After completing the admission examination of higher education, some participants take the initiative to try to repair the relationship and adjust themselves to reach a reconciliation; Others are still growing up in the distressing experience.

Background Left atrial appendage (LAA) closure (LAAC) could prevent stroke in patients with atrial fibrillation. However, LAAC may impair the compliance of the left atrium and result in poor prognosis. This study aimed to comparatively evaluate the prognosis of LAAC among patients with different sizes of LAA orifice. Methods and Results Three hundred two consecutive patients who underwent successful LAAC were included and divided into 4 groups based on LAA orifice size that was measured using transesophageal echocardiography. Clinical outcomes including thromboembolic events, major cardiocerebrovascular adverse events, and acute heart failure (AHF) were compared among 4 quartile groups and between propensity‐score matched groups of large and small LAAs. Through follow‐up of 39.6±8.4 months, survival of thromboembolic events was similar. Survival of major cardiocerebrovascular adverse events was significantly lower in the group with the largest LAA orifice (log‐rank P

BackgroundThe high prevalence of cardiovascular diseases globally causes a great social burden and much individual suffering. The effective recognition of high-risk subjects is critical for primary prevention in the general population. In the elderly cohort, anthropometric measurements may have different prognostic values. Our study aimed to find convincing anthropometric measures to supplement conventional risk factors for major adverse cardiovascular events (MACEs) in the elderly cohort.Materials and MethodsA total of 1,576 elderly participants (44.5% male, aged 72.0 ± 6.0 years) recruited into the Northern Shanghai Study (2014–2015) were followed up between 2016 and 2017. Following the standard guideline for cardiovascular risk evaluation, all conventional cardiovascular risk factors were assessed. The body measures were made up of body weight, body height, hip circumference, waist circumference, and middle-upper arm circumference (MUAC). Organ damage (OD) markers for cardiac, vascular, and renal diseases will be evaluated by the standardized methods.ResultsAfter the average 571 (±135) days of follow-up, a total of 90 MACEs (5.7%) occurred, i.e., 13 non-fatal myocardial infarction, 68 non-fatal stroke, and 9 cardiovascular deaths. Univariable COX survival analysis revealed that only MUAC could validly predict MACEs among anthropometric characters [adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.82–0.96]. In Kaplan-Meier analysis, the group of high MUAC showed the lowest MACE risk (log-rank p = 0.01). Based on OD analysis, MUAC was independently linked to higher risk of left ventricular hypertrophy (LVH) in women and left ventricular diastolic dysfunction (LVDD) in both men and women. In adjusted COX analysis, only MUAC indicated statistical significance, but all other anthropometric parameters such as BMI, waist circumference, and waist-to-hip ratio (WHR) did not indicate significance. The higher level of MUAC remained a protective factor in fully adjusted models (HR: 0.73; 95% CI: 0.59–0.91), with p-values markedly significant in men (HR: 0.69; 95% CI: 0.49–0.97) and marginally significant in women (HR: 0.0.77; 95% CI: 0.59–1.01). After considering all factors (i.e., cardiovascular risk factors, MUAC, BMI, and WHR), the fully adjusted COX regression analysis demonstrated that the increased MUAC level was linked to decreased MACE risk in both men (HR: 0.57; 95% CI: 0.37–0.88) and women (aHR: 0.64; 95% CI: 0.46–0.93).ConclusionDespite being associated with a higher rate of cardiac damage, higher MUAC independently and significantly conferred protection against the MACE, in the elderly cohort.

Abstract Background Accumulated evidence has indicated that a high‐normal FT4 level is an independent risk factor for the clinical progression of AF. However, the association between elevated FT4 concentration within the normal range and AF recurrence after cryoballoon ablation in China is unknown. Methods This retrospective and observational study included 453 AF patients who underwent cryoballoon ablation from January 2016 to August 2018. Patients were classified into quartiles based on preprocedural serum FT4 concentration. The clinical characteristics of the patients and the long‐term rate of AF recurrence after ablation were assessed. Results After a mean follow‐up period of 17.4 ± 9.0 months, 91 (20.1%) patients suffered from AF recurrence. The AF recurrence rate by FT4 quartile was 17.7%, 19.0%, 21.4%, and 22.3% for participants with FT4 in quartile 1, 2, 3, and 4, respectively (p

Background: Left bundle branch pacing (LBBP) has been shown to be a safe and effective means to achieve physiological pacing. However, elderly patients have increased risks from invasive procedures and the risk of LBBP in elderly patients is not known. We aimed to investigate the safety and efficacy of LBBP in elderly patients >80 years of age.Methods: From December 2017 to June 2019, 346 consecutive patients with symptomatic bradycardia, 184 patients under 80 years of age and 162 over 80 years, were included and underwent LBBP. The safety and prognosis of LBBP were comparatively evaluated by measured pacing parameters, periprocedural complications, and follow-up clinical events.Results: Compared with the younger, the elderly group had worse baseline cardiac and renal function. LBBP was achieved successfully in both groups with comparable fluoroscopic time and paced QRS duration (110.0 [102.0, 118.0] ms for the young vs. 110.0 [100.0, 120.0] ms for the elderly, P = 0.874). Through a follow-up of 20.0 ± 6.1 months, pacing parameters were stable while higher threshold and impedance were observed in the elderly group. In the evaluation of safety, overall procedure-related complication rates were comparable (4.4 vs. 3.8%, young vs. elderly). For prognosis, similar rates of major adverse cardiocerebrovascular events (7.1 vs. 11.9%, young vs. elderly) were observed.Conclusions: Compared to younger patients, LBBP could achieve physiological pacing in patients over 80 with comparable midterm safety and prognosis. Long-term safety and benefits of LBBP, however, necessitate further evaluation.

Introduction: Serum homocysteine (Hcy) level is associated with cardiocerebrovascular disease. However, the relationship between Hcy and hypertension-mediated organ damage (HMOD) in non-hospitalized residents has not been elucidated. We aimed to investigate the association of HMOD with Hcy in elderly Chinese.Methods: One thousand seven hundred and forty-four community-dwelling elderly Chinese (age ≥65 years) participated in the Northern Shanghai Study from Jun. 2014 to Aug. 2015. Hyperhomocysteinemia (HHcy) was defined as serum Hcy ≥15 mmol/L, and HMOD was estimated as arterial stiffness [carotid-femoral pulse wave velocity (CF-PWV) and ankle-brachial index (ABI)], cardiac impairment [left ventricular (LV) hypertrophy and LV diastolic dysfunction], and renal dysfunction [estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio]. Linear and logistic regression models were built to explore the associations of HMOD with Hcy.Results: Among 1,744 participants, 632 (36.2%) were diagnosed as HHcy. HHcy group had more men (61.2 vs. 35.3%), with higher age (73.7 ± 6.7 vs. 70.4 ± 5.3 years) and BMI (24.2 ± 3.4 vs. 23.7 ± 3.5 kg/m2). Linear regression analysis showed that serum Hcy level was positively associated CF-PWV and negatively associated with ABI and eGFR. By logistic regression, HHcy was significantly associated with abnormal CF-PWV [odds ratio (OR) = 1.53, 95% confidence interval (CI) 1.08–2.16] and ABI (OR = 1.55, 95% CI 1.17–2.04), and decreased eGFR (OR = 7.09, 95% CI 4.03–12.47) after adjustment for covariates. Moreover, similar associations of serum Hcy level with CF-PWV and eGFR were observed in subgroups by gender and hypertensive state.Conclusion: HMOD, particularly renal dysfunction and arterial stiffening, was significantly and independently associated with increased serum Hcy level in the elderly Chinese.Clinical Trial Registration: [ClinicalTrial.gov], identifier [NCT02368938].

Leaching technique was mostly carried out on submarine rock powder to minimize or eliminate secondary effect of seawater interaction on Sr and Pb isotope magmatic signatures. However, the effect of leaching on trace element contents is comparatively poorly established. To investigate such effects, we have compared trace element and Nd-Pb isotopic data for acid leached ∼290 Ma Keping basalts in the Tarim Large Igneous Province (NW China) with unleached data on the same rocks. Rare earth elements (REE), Y, Th and U contents of leached sample grains (0.6–1.0 mm size) are 10–65% lower than those of unleached grains of the same sample, whereas other trace elements are not affected. Sm/Nd, Lu/Hf, U/Pb and Th/Pb ratios are fractionated by acid leaching between leached and unleached sample grains. Nd isotope values are unaffected by leaching, but 208Pb/204Pb and 206Pb/204Pb values of leached samples are significantly lower than those of unleached samples. X-ray diffraction results suggest that removal of secondary epidote during the acid leaching process could result in the fractionation of REE, Y, Th and U contents, and Sm/Nd, Lu/Hf, U/Pb and Th/Pb ratios, and 208Pb/204Pb and 206Pb/204Pb values. These results suggest that when the samples have been leached with strong acid (>1N HCl), their trace element cannot be used to trace the sources and petrogenesis. If leaching is applied to old (e.g., >100 Ma) continental basalts in order to eliminate contamination during sample collection, storage, sawing and crushing, Th/Pb and U/Pb ratios used to calculate the initial Pb isotope values, should be obtained on the same leached samples. Keywords: Tarim Large Igneous Province, Trace element, Nd-Pb isotopes, Alteration, Acid leaching

Objective: Catheter ablation combined with left atrial appendage closure (LAAC) has emerged as a promising strategy for atrial fibrillation (AF) patients at high risk for stroke or with contraindications for oral anticoagulants (OACs). But the evidence for the long-term safety and efficacy of a combined procedure using cryoballoon ablation (CBA) with LAAC is still insufficient.Methods: From October 2015 to December 2017, a total of 76 consecutive non-valvular, drug-refractory AF patients who underwent a combined procedure of CBA and LAAC are included. Peri- and post-procedural safety and efficacy were evaluated through scheduled follow-ups and transesophageal echocardiography (TEE).Results: A total of 74 patients (97.4%) underwent the combined procedure and achieved instant pulmonary vein isolation and satisfactory LAAC. With a mean follow-up time of 23.7 ± 11.0 months, the recurrence of atrial arrhythmia was recorded in 35 patients (48.0%). In addition, a survival analysis shows a non-significant higher recurrence in persistent AF (p = 0.48). The overall OAC withdrawal rate was 97.2%, and one patient (1.4%) had a lethal hemorrhagic stroke while on single antiplatelet therapy. For safety concerns, the overall mortality was 2.7%, which resulted from one case of myocardial infarction on OAC and one hemorrhagic stroke, as mentioned. No other major hemorrhagic events occurred. Among the 72 patients (94.7%) who underwent TEE, one patient (1.4%) had device-related thrombosis and one patient (1.4%) had prominent residual flow (over 3 mm). Both were prescribed long-term OACs without severe complications occurring.Conclusions: Combining CBA with LAAC in a single procedure achieved considerable long-term safety and efficacy, providing a promising strategy for AF management.

The evidential reasoning (ER) approach has been widely applied to aggregate evaluation information in multi-expert multi-criterion decision-making (MEMCDM) problems with uncertainties. However, the comprehensive results derived by the ER approach remain uncertain. In this study, we propose a Deng-entropy-based ER approach for MEMCDM problems to reduce the uncertainty. Firstly, we reassign the remaining belief of the uncertain evaluation information to the focal elements of the given evaluations. Afterward, we introduce the Deng entropy to respectively calculate the objective weights of criteria and those of experts, so as to reduce the subjective uncertainty in MEMCDM. Then, the ER approach is applied twice to generate the comprehensive evaluations of alternatives. A method is introduced to rank alternatives corresponding to their comprehensive evaluations, forming a Deng-entropy-based ER approach for MEMCDM problems with uncertainty. An illustrative example of screening the people at high risk of lung cancer is provided, and comparative analyses are given to show the rationality and superiority of the proposed method.

Non-invasive ultrasonic neural modulation (UNM), a non-invasive technique with enhanced spatial focus compared to conventional electrical neural modulation, has attracted much attention in recent decades and might become the mainstream regimen for neurological disorders. However, as ultrasonic bioeffects and its adjustments are still unclear, it remains difficult to be extensively applied for therapeutic purpose, much less in the setting of human skull. Hence to comprehensively understand the way ultrasound exerts bioeffects, we explored UNM from a basic perspective by illustrating the parameter settings and the underlying mechanisms. In addition, although the spatial resolution and precision of UNM are considerable, UNM is relatively non-specific to tissue or cell type and shows very low specificity at the molecular level. Surprisingly, Ibsen et al. (2015) first proposed the concept of sonogenetics, which combined UNM and mechanosensitive (MS) channel protein. This emerging approach is a valuable improvement, as it may markedly increase the precision and spatial resolution of UNM. It seemed to be an inspiring tool with high accuracy and specificity, however, little information about sonogenetics is currently available. Thus, in order to provide an overview of sonogenetics and prompt the researches on UNM, we summarized the potential mechanisms from a molecular level.

Background. Catheter ablation combined with left atrial appendage closure (LAAC) was reported as a feasible strategy for atrial fibrillation (AF) patients with high risk of stroke or contraindications of oral anticoagulants. We aimed to observe the short-term safety and efficacy of combining cryoballoon ablation (CBA) with LAAC in paroxysmal (PAF) patients. Method and Results. From Jan 2016 to Dec 2017, 304 patients diagnosed with nonvalvular, drug-refractory PAF were included, who underwent either CBA alone (n = 262) or combined procedure (n = 42). Instant pulmonary vein isolation (PVI) with CBA was achieved in all patients, while successful LAAC achieved in 41 (97.6%) of combined procedure patients. 1-year freedom of AF rate was lower in combined procedure group (84.7% vs 70.7%, p=0.04), with unadjusted hazard ratio (HR = 1.97) and 95% confidence interval (CI) 1.03–3.77. However, the multivariate COX model revealed left atrial diameter (p=0.002, HR = 1.10, and 95% CI 1.04, 1.17), rather than procedure type (p=0.51, HR = 1.34, and 95% CI 0.57, 3.17), was the predictor for freedom of AF. Only 2 patients in the CBA group had stroke, contributing to the nonsignificant higher stroke incidence (p=1.00). Transoesophageal echochardiography (TEE) achieved in 35 patients (83.3%) showed complete occlusion with no obvious residual flow (>3 mm), Device-related thrombosis, or pericardial perfusion. All-cause mortality, rehospitalization, and complication rates were similar. Conclusion. Combining CBA with LAAC in a single procedure is a feasible strategy for PAF patients, with comparable short-term safety and efficacy to CBA alone.

A direct and continuous approach to determine simultaneously protein and phosphate concentrations in cells and kinetics of phosphate release from physiological substrates by cells without any labeling has been developed. Among the enzymes having a phosphatase activity, tissue non-specific alkaline phosphatase (TNAP) performs indispensable, multiple functions in humans. It is expressed in numerous tissues with high levels detected in bones, liver and neurons. It is absolutely required for bone mineralization and also necessary for neurotransmitter synthesis. We provided the proof of concept that infrared spectroscopy is a reliable assay to determine a phosphatase activity in the osteoblasts. For the first time, an overall specific phosphatase activity in cells was determined in a single step by measuring simultaneously protein and substrate concentrations. We found specific activities in osteoblast like cells amounting to 116 ± 13 nmol min(-1) mg(-1) for PPi, to 56 ± 11 nmol min(-1) mg(-1) for AMP, to 79 ± 23 nmol min(-1) mg(-1) for beta-glycerophosphate and to 73 ± 15 nmol min(-1) mg(-1) for 1-alpha-D glucose phosphate. The assay was also effective to monitor phosphatase activity in primary osteoblasts and in matrix vesicles. The use of levamisole--a TNAP inhibitor--served to demonstrate that a part of the phosphatase activity originated from this enzyme. An IC50 value of 1.16 ± 0.03 mM was obtained for the inhibition of phosphatase activity of levamisole in osteoblast like cells. The infrared assay could be extended to determine any type of phosphatase activity in other cells. It may serve as a metabolomic tool to monitor an overall phosphatase activity including acid phosphatases or other related enzymes.

The trend of intellectualization and complication of mechanical equipment makes the demand for intelligent diagnostic methods more and more intense in industry. In view of the difficulty of obtaining mechanical fault samples and the requirement of clear and reliable diagnosis results, intelligent diagnosis methods need to adapt to the learning of small samples and have the interpretability of white box model. In this paper, inspired by biological immunity, an intelligent fault diagnosis method was proposed--optimizing b-cell pool clonal selection classification algorithm (OBPCSCA). The OBPCSCA provides a method to construct unique B-cell pools corresponding to specific antigen pools, and uses greedy strategy to generate memory B-cell pools. The experimental comparison with AIRS and AICSL on four UCI benchmark data sets shows that the OBPCSCA has a better balance between the number of memory cells and the accuracy of classification. In particular, compared with AIRS, the OBPCSCA can greatly reduce the number of memory B-cells on the premise of ensuring high classification accuracy. In comparison with the top general classifiers, the OBPCSCA has certain competitiveness in these four data sets. Finally, the algorithm was applied to the bearing data set of Case Western Reserve University for fault diagnosis, and the results showed effectiveness of the algorithm. [ABSTRACT FROM AUTHOR]

A method with simplified chemical treatment has developed to determine high-precision δ11B in silicate rocks by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) using sample-standard-bracketing (SSB) mode. Boron in silicate rocks was extracted by digesting with HF, and purified by a single ion-exchange chromatographic step through a column filled with AG MP anion resin. Only one dryness process was involved in the entire chemical treatment procedure. This simplified procedure diminishes the risk of boron contamination and losses during chemical treatment. An introduction system with a PFA spray chamber and a sapphire injector was adopted to decrease boron memory during the measurement on MC-ICP-MS, which provides high-precision δ11B results. The internal precision for δ11B was better than ±0.05‰ (2σ standard error), and the external precision for δ11B was better than ±0.30‰ (2σ standard error) estimated by the long-term results of SRM 951. The δ11B of a series of international rock standard references were measured by this method. Some of the samples have δ11B reference values, and our results agree well with them within analytical errors. This indicates that our method is feasible for high-precision δ11B measurement in various silicate rocks, and our results may provide δ11B reference values for these rock standards. [ABSTRACT FROM AUTHOR]

Giant plagioclase crystals carried into the Panzhihua gabbroic layered intrusion from a deeper magma chamber can help constrain the timescales of emplacement of the Panzhihua intrusion in the Emeishan large igneous province (LIP). In this study, we present the petrographic textures and chemical compositions of giant plagioclase and fine-grained gabbro samples along a ~ 50 m horizontal outcrop of the low zone of the Panzhihua deposit. The giant plagioclase gabbro (GPG) dykes mostly intrude into the fine-grained gabbros without significant contact. Both types of gabbros have the similar bulk-rock major and trace element compositions. However, the mineral composition shows that most of the plagioclase megacrysts contain less An than the plagioclase in fine-grained gabbro samples. In situ analyses of Sr isotopes from core-to-rim transects of plagioclase megacrysts are constant, indicating that there are no recycled crystals. The textural characteristics of samples combined with petrological modeling using MELTS suggest that the plagioclase megacrysts should crystallize and grow in a deeper magma chamber. Textual studies of the GPG indicate that these plagioclase megacrysts mostly plot as straight lines on a classic crystal size distribution (CSD) diagram. For a plagioclase growth range of 10- 11-10- 10 mm/s, the plagioclase should have a growth time of 530-8118 years. In a 100 km³ magma chamber releasing thermal energy at a rate of 1000 MW, the Panzhihua intrusion should reach 50% crystallization after ~ 2400 years. The growth time recorded by the megacrysts in the GPG and numerical modeling may indicate that the emplacement and crystallization of the Panzhihua intrusion may have taken place in thousands of years. In the Emeishan LIP, therefore the combination of large volumes of Fe-rich magma flux and efficient metal precipitation led to the formation of a giant Fe-Ti-V oxide deposit in a short period. [ABSTRACT FROM AUTHOR]