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In this book, key experts in the field of total synthesis of natural products in Japan describe the details of their synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments, including those routes that were unsuccessful the book provides the reader with a better understanding of how other researchers devise their strategy and overcome difficulties in their studies. The contributions in the book have focused on highlighting the research from Japan however it is appealing to researchers and students worldwide. This compilation of cutting-edge natural product synthesis provides high-quality expertise, especially to graduate students and young researchers, regarding research on synthetic organic chemistry. It can be utilized as teaching material in university seminars as well as provide guidance to researchers in the area of total synthesis. This is an open access book.

This open access book provides a totally new perspective on the rapidly developing sector of electrochemical energy storage, putting a spotlight on their sustainability under consideration of the latest developments and emerging future technologies. A number of selected, high-level authors from different disciplines discuss the potential contribution of batteries to a cleaner society, the need for new battery concepts, necessary new chemistries and their sustainability. These include not only analyses of the most relevant technological developments in the field, but also the latest state of knowledge in terms of their applicative functionalities in transport and stationary applications within the clean energy transition framework, their potential environmental impacts, resource demands and social impacts, and the corresponding methodological advances. All these aspects are analyzed on micro-level (i.e., for the specific technology), but also on macro-scale i.e., from a systemic perspective, providing a glimpse on how emerging battery systems might cover future energy storage demand. By taking a prospective and interdisciplinary viewpoint, this book will be of interest for a broad field of readers interested in electrochemistry, engineering with particular focus on electric grids and on-board systems and energy system analysis, but also those worried about the sustainability and societal challenges related with the energy transition(s).

This open access book introduces the science of the new materials, soft crystals, by showing various interesting examples. Different from conventional hard and stable crystals, the soft crystals respond to gentle stimuli such as vapor exposure and rubbing but maintain their structural order. In this book, their exhibition of remarkable visual changes in their shape, color, and luminescence is described. Through the chapters, historical background, recent remarkable developments, and future prospects are described concisely. This book helps readers to understand a new concept of materials that have the characteristics of stimulus-sensitive soft matter and finely controlled crystals and to design novel materials with the characteristics. The English translation of this book from its Japanese language original manuscript was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text has subsequently been revised further by a professional copy editor in order to refine the work stylistically.

This book reviews successes and (remaining) challenges in vaccine development for the selected Neglected Tropical Diseases (NTD) of Leprosy, Leishmaniasis, Meliodoisis and Tuberculosis, which are a continuous burden for millions of people in affected areas worldwide. Written by frontline researchers, the volume deep-dives into different vaccine strategies, provides biotechnological background information and also tackles animal models in NTD therapeutics research. By bringing together state-of-the-art expert knowledge, the book contributes to the aim of ultimately ending the epidemics of neglected tropical diseases, complying with UN Sustainable Development Goal 3, Health and Well-Being. The volume highlights the activities of the research network VALIDATE (VAccine deveLopment for complex Intracellular neglecteD pAThogEns), funded by the Medical Research Council in the UK. The four NTDs discussed in the book were selected as these are in the focus of VALIDATE’s research. The book targets scientists and clinicians working on NTDs, as well as all readers with a background in biomedicine and interest in vaccine development. This is an open access book.

Volume 1 establishes the foundations of this new field. It goes through all the steps from data collection, their summary and clustering, to different aspects of resource-aware learning, i.e., hardware, memory, energy, and communication awareness. Machine learning methods are inspected with respect to resource requirements and how to enhance scalability on diverse computing architectures ranging from embedded systems to large computing clusters.

Volume 2 covers knowledge discovery in particle and astroparticle physics. Instruments gather petabytes of data and machine learning is used to process the vast amounts of data and to detect relevant examples efficiently. The physical knowledge is encoded in simulations used to train the machine learning models. The interpretation of the learned models serves to expand the physical knowledge resulting in a cycle of theory enhancement.

Volume 3 describes how resource-aware machine learning methods and techniques are used to successfully solve real-world problems. The book provides numerous specific application examples: in health and medicine for risk modelling, diagnosis, and treatment selection for diseases in electronics, steel production and milling for quality control during manufacturing processes in traffic, logistics for smart cities and for mobile communications.

This book draws attention to political aspects of sustainable development goal-setting, exploring the Sustainable Development Goals (SDGs) at the global-national nexus during their first five years. After broad global deliberation and political negotiations, the 2030 Agenda and its SDGs were adopted in the United Nations (UN) General Assembly in 2015, and by now many countries have political structures in place for working towards their realisation. This book explores three concepts to call attention to the political qualities of processes related to the SDGs: legitimacy, responsibility, and accountability. Legitimacy is required to obtain broad political ownership for policy goals in order for them to become effective in addressing cross-border sustainability challenges. Responsibility needs to be clearly distributed among political institutions if a long-term set of broad goals such as the SDGs are to be realised. Accountability to the public is the retrospective mirror of political responsibility. The Politics of the Sustainable Development Goals contributes new knowledge on political processes at the nexus of global and national levels, focussing on three countries at different levels of socio-economic development and democratisation: namely Ghana, Tanzania, and Sweden. These countries illustrate a variety of challenges related to the realisation of the SDGs. This book will be of great interest to students and scholars of sustainable development, international organisations, and global politics.

Emphasis on improved quality and performance of distilled products and the demand for reduced operating costs place a heavy burden on both the personnel responsible for profitability and the manufacturing department charged with operating the processing equipment. There have been dramatic improvements in the computer software and hardware used to simulate and model the distillation process and potential response to experimentation, but mastering the art of distillation process and control still requires solid understanding of a large body of information. With a focus on achieving product purity at low cost, Distillation Control, Optimization, and Tuning: Fundamentals and Strategies highlights core concepts. These include process variables for continuous binary distillation columns and the four basic control strategies, the distillate and bottoms product quality performance objectives, and the tuning of process control loops. Without dwelling on complex mathematical descriptions, the book presents the fundamentals of process control of a distillation column as a separation and purification unit operation. It covers the concepts and functional criteria that are critical to successful implementation of process control, as well as measurement and improvement of product quality performance. It describes how process control loops for distillation columns can be tuned for stable operation, with a balance between minimum variability from setpoint changes and excellent response to load disturbances. Designed for students, engineers, technicians, and plant operators alike, this book emphasizes the prevailing need to strike a balance between the details of hypotheses and good engineering judgment. The author outlines learning objectives at the beginning of each chapter and includes chapter-end summaries, exercises, and references to help readers acquire essential knowledge and understanding. The result is a resource that will inform future decisions for the design, operation, and troubleshooting of distillation process control systems.