Search

Your search keyword '"tumour cachexia"' showing total 5 results
Start Over Descriptor "tumour cachexia" Language english
5 results on '"tumour cachexia"'

1. Disease specific substrates in cancer cachexia – Reality and anticipation.

Author

Zadák, Zdeněk, Tichá, Alena, and Hyšpler, Radomír

Abstract

Abstract: In recent years, the concept of nutrition in patients with tumour diseases has been changing very significantly. The article discusses the pathogenesis of tumour cachexia and sarcopenia, which have been intensively studied, particularly in the last ten years. The possibilities and modern approaches in nutritional support in oncology are reviewed with a special emphasis on the group of elderly patients. Also, a detailed list of the most frequently used pharmaconutrients in oncology is presented. The recommendations for nutritional care of elderly oncological patients are given and discussed. [Copyright &y& Elsevier]

Published
2013
Full Text
View/download PDF

2. mTOR and Tumor Cachexia

Author

Duval, A.P., Jeanneret, C., Santoro, T., and Dormond, O.

Subjects
Animals, Cachexia/etiology, Cachexia/metabolism, Cachexia/pathology, Cell Proliferation, Humans, Lipid Metabolism, Muscle, Skeletal/metabolism, Muscle, Skeletal/pathology, Neoplasms/complications, Neoplasms/metabolism, Neoplasms/pathology, Signal Transduction, TOR Serine-Threonine Kinases/metabolism, lipolysis, mTOR, metabolism, proteolysis, signalling, tumour cachexia, digestive, oral, and skin physiology, musculoskeletal system, hormones, hormone substitutes, and hormone antagonists
Abstract

Cancer cachexia affects most patients with advanced forms of cancers. It is mainly characterized by weight loss, due to muscle and adipose mass depletion. As cachexia is associated with increased morbidity and mortality in cancer patients, identifying the underlying mechanisms leading to cachexia is essential in order to design novel therapeutic strategies. The mechanistic target of rapamycin (mTOR) is a major intracellular signalling intermediary that participates in cell growth by upregulating anabolic processes such as protein and lipid synthesis. Accordingly, emerging evidence suggests that mTOR and mTOR inhibitors influence cancer cachexia. Here, we review the role of mTOR in cellular processes involved in cancer cachexia and highlight the studies supporting the contribution of mTOR in cancer cachexia.

Published
2018

3. mTOR and Tumor Cachexia

Author

Olivier Dormond, Tania Santoro, Cheryl Jeanneret, and Adrian P. Duval

Subjects
0301 basic medicine, Cachexia, Anabolism, Adipose tissue, Review, lcsh:Chemistry, Weight loss, Neoplasms, signalling, lcsh:QH301-705.5, Spectroscopy, biology, TOR Serine-Threonine Kinases, digestive, oral, and skin physiology, General Medicine, musculoskeletal system, Computer Science Applications, mTOR, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, proteolysis, Catalysis, Inorganic Chemistry, 03 medical and health sciences, medicine, Animals, Humans, Physical and Theoretical Chemistry, Muscle, Skeletal, Molecular Biology, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cell Proliferation, business.industry, Organic Chemistry, Cancer, Lipid metabolism, Lipid Metabolism, medicine.disease, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Cancer research, lipolysis, business, metabolism, tumour cachexia
Abstract

Cancer cachexia affects most patients with advanced forms of cancers. It is mainly characterized by weight loss, due to muscle and adipose mass depletion. As cachexia is associated with increased morbidity and mortality in cancer patients, identifying the underlying mechanisms leading to cachexia is essential in order to design novel therapeutic strategies. The mechanistic target of rapamycin (mTOR) is a major intracellular signalling intermediary that participates in cell growth by upregulating anabolic processes such as protein and lipid synthesis. Accordingly, emerging evidence suggests that mTOR and mTOR inhibitors influence cancer cachexia. Here, we review the role of mTOR in cellular processes involved in cancer cachexia and highlight the studies supporting the contribution of mTOR in cancer cachexia.

Published
2018

4. mTOR and Tumor Cachexia.

Author

Duval, Adrian P., Jeanneret, Cheryl, Santoro, Tania, and Dormond, Olivier

Subjects
*CACHEXIA, *CANCER, *WEIGHT loss, *ADIPOSE tissues, *CANCER patients
Abstract

Cancer cachexia affects most patients with advanced forms of cancers. It is mainly characterized by weight loss, due to muscle and adipose mass depletion. As cachexia is associated with increased morbidity and mortality in cancer patients, identifying the underlying mechanisms leading to cachexia is essential in order to design novel therapeutic strategies. The mechanistic target of rapamycin (mTOR) is a major intracellular signalling intermediary that participates in cell growth by upregulating anabolic processes such as protein and lipid synthesis. Accordingly, emerging evidence suggests that mTOR and mTOR inhibitors influence cancer cachexia. Here, we review the role of mTOR in cellular processes involved in cancer cachexia and highlight the studies supporting the contribution of mTOR in cancer cachexia. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

5. Disease specific substrates in cancer cachexia - Reality and anticipation.

Author

Zadák Z, Tichá A, and Hyšpler R

Abstract

In recent years, the concept of nutrition in patients with tumour diseases has been changing very significantly. The article discusses the pathogenesis of tumour cachexia and sarcopenia, which have been intensively studied, particularly in the last ten years. The possibilities and modern approaches in nutritional support in oncology are reviewed with a special emphasis on the group of elderly patients. Also, a detailed list of the most frequently used pharmaconutrients in oncology is presented. The recommendations for nutritional care of elderly oncological patients are given and discussed.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results