7 results on '"van Gerven, Nicole M. F."'
Search Results
2. Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis
- Author
-
van Gerven, Nicole M. F., de Boer, Ynto S., Zwiers, Antonie, van Hoek, Bart, van Erpecum, Karel J., Beuers, Ulrich, van Buuren, Henk R., Drenth, Joost P. H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M. J., Vrolijk, Jan M., Kraal, G., Mulder, Chris J. J., van Nieuwkerk, Carin. M. J., and Bouma, Gerd
- Published
- 2013
- Full Text
- View/download PDF
3. Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands
- Author
-
van Gerven, Nicole M. F., van der Eijk, Annemiek A., Pas, Suzan D., Zaaijer, Hans L., de Boer, Ynto S., Witte, Birgit I., van Nieuwkerk, Carin M. J., Mulder, Chris J. J., de Man, Robert A., Gastroenterology and hepatology, AII - Inflammatory diseases, and Epidemiology and Data Science
- Published
- 2016
4. Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1.
- Author
-
de Boer, Ynto S., van Gerven, Nicole M. F., Zwiers, Antonie, Verwer, Bart J., van Hoek, Bart, van Erpecum, Karel J., Beuers, Ulrich, van Buuren, Henk R., Drenth, Joost P. H., den Ouden, Jannie W., Verdonk, Robert C., Koek, Ger H., Brouwer, Johannes T., Guichelaar, Maureen M. J., Vrolijk, Jan M., Kraal, Georg, Mulder, Chris J. J., van Nieuwkerk, Carin M. J., Fischer, Janett, and Berg, Thomas
- Abstract
Background & Aims Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease of unknown etiology. We used a genome-wide approach to identify genetic variants that predispose individuals to AIH. Methods We performed a genome-wide association study of 649 adults in The Netherlands with AIH type 1 and 13,436 controls. Initial associations were further analyzed in an independent replication panel comprising 451 patients with AIH type 1 in Germany and 4103 controls. We also performed an association analysis in the discovery cohort using imputed genotypes of the major histocompatibility complex region. Results We associated AIH with a variant in the major histocompatibility complex region at rs2187668 (P = 1.5 x 10
-78 ). Analysis of this variant in the discovery cohort identified HLA-DRB1*0301 (P = 5.3 x 10-49 ) as a primary susceptibility genotype and HLA-DRB1*0401 (P = 2.8 x 10-18 ) as a secondary susceptibility genotype. We also associated AIH with variants of SH2B3 (rs3184504, 12q24; P = 7.7 x 10-8 ) and CARD10 (rs6000782, 22q13.1; P = 3.0 x 10-6 ). In addition, strong inflation of association signal was found with single-nucleotide polymorphisms associated with other immune-mediated diseases, including primary sclerosing cholangitis and primary biliary cirrhosis, but not with single-nucleotide polymorphisms associated with other genetic traits. Conclusions In a genome-wide association study, we associated AIH type 1 with variants in the major histocompatibility complex region, and identified variants of SH2B3and CARD10 as likely risk factors. These findings support a complex genetic basis for AIH pathogenesis and indicate that part of the genetic susceptibility overlaps with that for other immune-mediated liver diseases. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
5. Seroprevalence of Hepatitis E Virus in Autoimmune Hepatitis Patients in the Netherlands.
- Author
-
van Gerven NM, van der Eijk AA, Pas SD, Zaaijer HL, de Boer YS, Witte BI, van Nieuwkerk CM, Mulder CJ, Bouma G, and de Man RA
- Subjects
- Adolescent, Adult, Aged, Biomarkers blood, Female, Hepatitis E blood, Hepatitis E diagnosis, Hepatitis E immunology, Hepatitis, Autoimmune blood, Hepatitis, Autoimmune diagnosis, Hepatitis, Autoimmune immunology, Humans, Male, Middle Aged, Netherlands epidemiology, Prevalence, Retrospective Studies, Seroepidemiologic Studies, Serologic Tests, Young Adult, Endemic Diseases, Hepatitis Antibodies blood, Hepatitis E epidemiology, Hepatitis E virus immunology, Hepatitis, Autoimmune epidemiology, Immunoglobulin G blood
- Abstract
Background and Aims: In recent years chronic courses of hepatitis E virus (HEV) infection have been described in immunosuppressed individuals. This may implicate a potential role for HEV in the development of autoimmune diseases, including autoimmune hepatitis (AIH). Here we investigated the prevalence of HEV-antibodies in AIH patients in an endemic Central European country., Methods: HEV-specific immunoglobulin G (IgG) and HEV RNA were determined in 354 and 377 AIH patients, respectively. Clinical characteristics and disease outcome parameters were retrospectively collected., Results: No HEV viraemic patients were identified in this cohort. A total of 106 AIH patients (29.9%) tested positive for anti-HEV IgG, and this figure was slightly higher compared to the prevalence in a reference cohort including 5,329 healthy Dutch blood donors (26.7%; P>0.05)., Conclusion: This is the largest study on the association between HEV infection and AIH. Apparently silent HEV infection is present in a significant proportion of AIH patients, yet appears not to have significant clinical repercussions in this immune compromised group of patients. Nevertheless, since acute hepatitis E may present with histological and biochemical features of AIH, the possibility of a (concomitant) HEV infection should be considered in this category of patients.
- Published
- 2016
- Full Text
- View/download PDF
6. Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands.
- Author
-
van Gerven NM, Verwer BJ, Witte BI, van Erpecum KJ, van Buuren HR, Maijers I, Visscher AP, Verschuren EC, van Hoek B, Coenraad MJ, Beuers UH, de Man RA, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Vrolijk JM, Mulder CJ, van Nieuwkerk CM, and Bouma G
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alanine Transaminase blood, Alkaline Phosphatase blood, Anti-Inflammatory Agents therapeutic use, Antibodies, Antinuclear blood, Asian People statistics & numerical data, Black People statistics & numerical data, Child, Child, Preschool, Fatigue etiology, Female, Hepatitis, Autoimmune diagnosis, Hepatitis, Autoimmune drug therapy, Hepatitis, Autoimmune genetics, Humans, Immunoglobulin G blood, Immunosuppressive Agents therapeutic use, Incidence, Jaundice etiology, Liver Cirrhosis epidemiology, Male, Middle Aged, Netherlands epidemiology, Prevalence, Retrospective Studies, Sex Factors, South America ethnology, Surveys and Questionnaires, White People statistics & numerical data, Young Adult, Carcinoma, Hepatocellular epidemiology, Hepatitis, Autoimmune epidemiology, Liver Neoplasms epidemiology
- Abstract
Background and Aims: Epidemiological data on autoimmune hepatitis (AIH) are scarce. In this study, we determined the clinical and epidemiological characteristics of AIH patients in the Netherlands (16.7 million inhabitants)., Methods: Clinical characteristics were collected from 1313 AIH patients (78% females) from 31 centers, including all eight academic centers in the Netherlands. Additional data on ethnicity, family history and symptoms were obtained by the use of a questionnaire., Results: The prevalence of AIH was 18.3 (95% confidential interval [CI]: 17.3-19.4) per 100,000 with an annual incidence of 1.1 (95% CI: 0.5-2) in adults. An incidence peak was found in middle-aged women. At diagnosis, 56% of patients had fibrosis and 12% cirrhosis in liver biopsy. Overall, 1% of patients developed HCC and 3% of patients underwent liver transplantation. Overlap with primary biliary cirrhosis and primary sclerosing cholangitis was found in 9% and 6%, respectively. The clinical course did not differ between Caucasian and non-Caucasian patients. Other autoimmune diseases were found in 26% of patients. Half of the patients reported persistent AIH-related symptoms despite treatment with a median treatment period of 8 years (range 1-44 years). Familial occurrence was reported in three cases., Conclusion: This is the largest epidemiological study of AIH in a geographically defined region and demonstrates that the prevalence of AIH in the Netherlands is uncommon. Although familial occurrence of AIH is extremely rare, our twin data may point towards a genetic predisposition. The high percentage of patients with cirrhosis or fibrosis at diagnosis urges the need of more awareness for AIH.
- Published
- 2014
- Full Text
- View/download PDF
7. Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission.
- Author
-
van Gerven NM, Verwer BJ, Witte BI, van Hoek B, Coenraad MJ, van Erpecum KJ, Beuers U, van Buuren HR, de Man RA, Drenth JP, den Ouden JW, Verdonk RC, Koek GH, Brouwer JT, Guichelaar MM, Mulder CJ, van Nieuwkerk KM, and Bouma G
- Subjects
- Adolescent, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones adverse effects, Adult, Aged, Azathioprine administration & dosage, Azathioprine adverse effects, Child, Female, Follow-Up Studies, Hepatitis, Autoimmune immunology, Humans, Immunosuppressive Agents administration & dosage, Kaplan-Meier Estimate, Male, Middle Aged, Recurrence, Remission Induction, Retrospective Studies, Risk Factors, Substance Withdrawal Syndrome immunology, Young Adult, Hepatitis, Autoimmune drug therapy, Hepatitis, Autoimmune epidemiology, Immunosuppressive Agents adverse effects, Substance Withdrawal Syndrome epidemiology
- Abstract
Background & Aims: Current treatment strategies in autoimmune hepatitis (AIH) include long-term treatment with corticosteroids and/or azathioprine. Here we determined the risk of relapse after drug withdrawal in patients in long-term remission and factors associated with such a relapse., Methods: A total of 131 patients (out of a cohort including 844 patients) from 7 academic and 14 regional centres in the Netherlands were identified in whom treatment was tapered after at least 2 years of clinical and biochemical remission. Relapse was defined as alanine-aminotransferase levels (ALT) three times above the upper limit of normal and loss of remission as a rising ALT necessitating the reinstitution of drug treatment., Results: During follow-up, 61 (47%) patients relapsed and 56 (42%) had a loss of remission. In these 117 patients, 60 patients had fully discontinued medication whereas 57 patients were still on a withdrawal scheme. One year after drug withdrawal, 59% of the patients required retreatment, increasing to 73% and 81% after 2 and 3 years, respectively. Previous combination therapy of corticosteroids and azathioprine, a concomitant autoimmune disease and younger age at time of drug withdrawal were associated with an increased risk of relapse. Subsequent attempts for discontinuation after initial failure in 32 patients inevitably resulted in a new relapse., Conclusions: This retrospective analysis indicates that loss of remission or relapse occurs in virtually all patients with AIH in long-term remission when immunosuppressive therapy is discontinued. These findings indicate a reluctant attitude towards discontinuation of immunosuppressive treatment in AIH patients., (Copyright © 2012. Published by Elsevier B.V.)
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.