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112 results on '"van Leeuwen, Fijs W.B."'

5. Prostate-specific membrane antigen Radioguided Surgery to Detect Nodal Metastases in Primary Prostate Cancer Patients Undergoing Robot-assisted Radical Prostatectomy and Extended Pelvic Lymph Node Dissection: Results of a Planned Interim Analysis of a Prospective Phase 2 Study

Author

Gandaglia, Giorgio, Mazzone, Elio, Stabile, Armando, Pellegrino, Antony, Cucchiara, Vito, Barletta, Francesco, Scuderi, Simone, Robesti, Daniele, Leni, Riccardo, Samanes Gajate, Ana Maria, Picchio, Maria, Gianolli, Luigi, Brembilla, Giorgio, De Cobelli, Francesco, van Oosterom, Matthias N., van Leeuwen, Fijs W.B., Montorsi, Francesco, and Briganti, Alberto

Published
2022
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15. Near-infrared fluorescence imaging compared to standard sentinel lymph node detection with blue dye in patients with vulvar cancer – a randomized controlled trial

Author

Deken, Marion M., van Doorn, Helena C., Verver, Danielle, Boogerd, Leonora S.F., de Valk, Kim S., Rietbergen, Daphne D.D., van Poelgeest, Mariëtte I.E., de Kroon, Cor D., Beltman, Jogchum J., van Leeuwen, Fijs W.B., Putter, Hein, Braak, Jeffrey P.B.M., de Geus-Oei, Lioe-Fee, van de Velde, Cock J.H., Burggraaf, Jacobus, Vahrmeijer, Alexander L., and Gaarenstroom, Katja N.

Published
2020
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19. Single Lesion on Prostate-specific Membrane Antigen-ligand Positron Emission Tomography and Low Prostate-specific Antigen Are Prognostic Factors for a Favorable Biochemical Response to Prostate-specific Membrane Antigen-targeted Radioguided Surgery in Recurrent Prostate Cancer

Author

Horn, Thomas, Krönke, Markus, Rauscher, Isabel, Haller, Bernhard, Robu, Stephanie, Wester, Hans-Jürgen, Schottelius, Margret, van Leeuwen, Fijs W.B., van der Poel, Henk G., Heck, Matthias, Gschwend, Jürgen E., Weber, Wolfgang, Eiber, Matthias, and Maurer, Tobias

Published
2019
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22. The realization of medical devices for precision surgery – development and implementation of 'stop-and-go' imaging technologies.

Author

van Leeuwen, Fijs W.B., Buckle, Tessa, Rietbergen, Daphne D.D., and van Oosterom, Matthias N.

Subjects
MEDICAL equipment, SURGICAL indications, COMPUTER-assisted surgery, SURGICAL technology, CLINICAL medicine, UROLOGISTS
Abstract

Surgery and biomedical imaging encompass a big share of the medical-device market. The ever-mounting demand for precision surgery has driven the integration of these two into the field of image-guided surgery. A key-question herein is how imaging modalities can guide the surgical decision-making process. Through performance-based design, chemists, engineers, and doctors need to build a bridge between imaging technologies and surgical challenges. This perspective article highlights the complementary nature between the technological design of an image-guidance modality and the type of procedure performed. The specific roles of the involved professionals, imaging technologies, and surgical indications are addressed. Molecular-image-guided surgery has the potential to advance pre-, intra- and post-operative tissue characterization. To achieve this, surgeons need the access to well-designed indication-specific chemical-agents and detection modalities. Hereby, some technologies stimulate exploration ('go'), while others stimulate caution ('stop'). However, failing to adequately address the indication-specific needs rises the risk of incorrect tool employment and sub-optimal surgical performance. Therefore, besides the availability of new technologies, market growth is highly dependent on the practical nature and impact on real-life clinical care. While urology currently takes the lead in the widespread implementation of image-guidance technologies, the topic is generic and its popularity spreads rapidly within surgical oncology. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

Author

Burggraaf, Jacobus, Kamerling, Ingrid M.C., Gordon, Paul B., Schrier, Lenneke, de Kam, Marieke L., Kales, Andrea J., Bendiksen, Ragnar, Indrevoll, Bard, Bjerke, Roger M., Moestue, Siver A., Yazdanfar, Siavash, Langers, Alexandra M.J., Swaerd-Nordmo, Marit, Torheim, Geir, Warren, Madhuri V., Morreau, Hans, Voorneveld, Philip W., Buckle, Tessa, van Leeuwen, Fijs W.B., Odegardstuen, Liv-Ingrid, Dalsgaard, Grethe T., Healey, Andrew, and Hardwick, James C.H.

Subjects
Polyps (Pathology) -- Diagnosis, Colon cancer -- Prevention, Colonoscopy -- Usage, Biological sciences, Health
Abstract

Colon cancer prevention currently relies on colonoscopy using white light to detect and remove polyps, but small and flat polyps are difficult to detect and frequently missed when using this technique. Fluorescence colonoscopy combined with a fluorescent probe specific for a polyp biomarker may improve polyp detection. Here we describe GE-137, a water-soluble probe consisting of a 26-amino acid cyclic peptide that binds the human tyrosine kinase c-Met conjugated to a fluorescent cyanine dye. Intravenous administration of GE-137 leads to its accumulation specifically in c-Met-expressing tumors in mice, and it is safe and well tolerated in humans. Fluorescence colonoscopy in patients receiving intravenous GE-137 enabled visualization of all neoplastic polyps that were visible with white light (38), as well as an additional nine polyps that were not visible with white light. This first-in-human pilot study shows that molecular imaging using an intravenous fluorescent agent specific for c-Met is feasible and safe, and that it may enable the detection of polyps missed by other techniques., Colorectal cancer (CRC) is a major cause of cancer death (1), and colonoscopy is firmly established as the mainstay of CRC prevention. Evidence that CRC can be prevented by the [...]

Published
2015
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41. Incidence and risk factor analysis of complications after sentinel node biopsy for penile cancer.

Author

Wever, Lieke, de Vries, Hielke M., Dell'Oglio, Paolo, van der Poel, Henk G., Donswijk, Maarten L., Sikorska, Karolina, van Leeuwen, Fijs W.B., Horenblas, Simon, and Brouwer, Oscar R.

Subjects
SENTINEL lymph nodes, PENILE cancer, FACTOR analysis, PREOPERATIVE risk factors, RISK assessment, SURGICAL complications, PENILE transplantation
Abstract

Objective: To determine the incidence and types of complications after dynamic sentinel node biopsy (DSNB) in patients with penile cancer (PeCa) and identify risk factors for the occurrence of postoperative complications. Patients and Methods: We evaluated 644 patients with PeCa (1284 DSNB procedures) with at least one clinically node negative (cN0) groin who underwent DSNB between 2011 and 2020 at a single high‐volume centre. The 30‐ and 30–90‐day postoperative complications were collected according to the modified Clavien–Dindo classification and the standardised methodology proposed by the European Association of Urology panel. Uni‐ and multivariable generalised linear mixed models were used to identify risk factors for the occurrence of complications per groin. Results: A 30‐day postoperative complication occurred in 14% of groins (n = 186), of which 94% were mild to moderate. Wound infection and lymphocele formation were most common. A 30–90‐day postoperative complication occurred in 3.4% of the groins, all of which were mild or moderate (Grade I–II). The number of removed lymph nodes (LNs) per groin was the main independent predictor for any 30‐day complications and Grade ≥II complications (odds ratio 1.40; P < 0.001). There was an increase in the probability of postoperative complications with the number of LNs removed after accounting for all confounders. Conclusions: Despite being less morbid than (modified) inguinal LN dissection, DSNB is still associated with a considerable risk of postoperative mild‐to‐moderate complications. This risk increases with increasing number of LNs removed. Further procedural refinement aimed at removing the true sentinel node(s) only, may help further reduce the morbidity of surgical staging in PeCa. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

Author

Rottenberg, Sven, Nygren, Anders O.H., Pajic, Marina, Van Leeuwen, Fijs W.B., Van der Heijden, Ingrid, Van de Wetering, Koen, Liu, Xiaoling, De Visser, Karin E., Gilhuijs, Kenneth G., Van Tellingen, Olaf, Schouten, Jan P., Jonkers, Jos, and Borst, Piet

Subjects
Breast cancer -- Genetic aspects, Chemotherapy -- Physiological aspects, Breast tumors -- Care and treatment, Breast tumors -- Physiological aspects, Drug resistance -- Evaluation, Cancer -- Chemotherapy, Cancer -- Physiological aspects, Science and technology
Abstract

We have studied in vivo responses of 'spontaneous' Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin, docetaxel, or cisplatin. Like human tumors, the response of individual mouse tumors varies, but eventually they all become resistant to the maximum tolerable dose of doxorubicin or docetaxel. The tumors also respond well to cisplatin but do not become resistant, even after multiple treatments in which tumors appear to regrow from a small fraction of surviving cells. Classical biochemical resistance mechanisms, such as up-regulated drug transporters, appear to be responsible for doxorubicin resistance, rather than alterations in drug-damage effector pathways. Our results underline the promise of these mouse tumors for the study of tumor-initiating cells and of drug therapy of human cancer. multidrug resistance | P-glycoprotein I cancer stem cells

Published
2007

46. Ionizable (thia)calix[4]crowns as highly selective [sup.226][Ra.sup.2+] ionophores

Author

van Leeuwen, Fijs W.B., Beijleveld, Hans, Miermans, Cornelis J.H., Huskens, Jurriaan, Verboom, Willem, and Reinhoudt, David N.

Subjects
Cations -- Research, Calixarenes -- Chemical properties, Ionization -- Research, Chemistry
Abstract

The [sup.226][Ra.sup.2+] selectivity of the ionizable (thia)calix[4]-crowns 1-4 was determined in the presence of a large excess of the most common alkali and alkaline earth cations. Selective [sup.226][Ra.sup.2+] (2.9 x [10.sup.-8] M) extraction occurs even at extremely high [M.sup.n+]/[sup.226][Ra.sup.2+] ratios of 3.5 x [10.sup.7] [[M.sup.n+] = [Na.sup.+], [K.sup.+], [Rb.sup.+], [Cs.sup.+], [Mg.sup.2+], [Ca.sup.2+], and [Sr.sup.2+] (1 M)] and an ionophore concentration of [10.sup.-4] M. The selectivity coefficients log([K.sup.Ra.sub.ex]/[K.sup.M.sub.ex]) are ~3.5 for [Mg.sup.2+], [Ca.sup.2+], and [Sr.sup.2+]. In the presence of [Ba.sup.2+], which has very similar chemical properties, only the thiacalix[4]crown-6 derivative 4 showed a selectivity for [sup.226][Ra.sup.2+]. In addition to the remarkable [sup.226][Ra.sup.2+] selectivities, the effective pH range (pH 8-13) of the thiacalix[4]crown dicarboxylic acids (3 and 4) allows for full regeneration of the ionophores at lower pH values (pH

Published
2005

47. Synthesis and conformational evaluation of p-tert-butylthiacalix[4]arene-crowns

Author

van Leeuwen, Fijs W.B., Beijleveld, Hans, Spek, Anthony L., Verboom, Willem, and Reinhoudt, David N.

Subjects
Chemistry, Organic -- Research, Biological sciences, Chemistry
Abstract

A systematic study on the formation and conformations of p-tert-butylthiacalix[4]arene-(bis)crowns-4, -5 and -6 was made. Temperature-dependent studies revealed that the conformationally flexible 1,3-dimethoxythiacalix-[4] arene-crowns exclusively occupy the 1,3-alternate conformation.

Published
2004

48. A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo

Author

Verdoes, Martijn, Florea, Bogdan I., Menendez-Benito, Victoria, Maynard, Christa J., Witte, Martin D., van der Linden, Wouter A., van den Nieuwendijk, Adrianus M.C.H., Hofmann, Tanja, Berkers, Celia R., van Leeuwen, Fijs W.B., Groothuis, Tom A., Leeuwenburgh, Michiel A., Ovaa, Huib, Neefjes, Jacques J., Filippov, Dmitri V., van der Marel, Gijs A., Dantuma, Nico P., and Overkleeft, Herman S.

Published
2006
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50. PD19-10 PSMA RADIO-GUIDED SURGERY TO DETECT NODAL METASTASES IN PROSTATE CANCER PATIENTS UNDERGOING ROBOT-ASSISTED RADICAL PROSTATECTOMY AND EXTENDED PELVIC LYMPH NODE DISSECTION: UPDATED RESULTS OF A PLANNED INTERIM ANALYSIS OF A PROSPECTIVE...

Author

Quarta, Leonardo, Mazzone, Elio, Gandaglia, Giorgio, Stabile, Armando, Cannoletta, Donato, Robesti, Daniele, Pellegrino, Antony, Leni, Riccardo, Cucchiara, Vito, Scuderi, Simone, Barletta, Francesco, Zaurito, Paolo, Samanes Gajate, Ana Maria, Brembilla, Giorgio, Van Oosterom, Matthias N., Van Leeuwen, Fijs W.B., Picchio, Maria, Chiti, Arturo, De Cobelli, Francesco, and Montorsi, Francesco

Subjects
PROSTATE cancer patients, RADICAL prostatectomy, SURGICAL robots, METASTASIS
Published
2024
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