425 results on '"van Ravenzwaay, Bennard"'
Search Results
2. A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
3. Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
4. The short-term toxicity and metabolome of Benzene
5. The short-term toxicity and metabolome of dicyclopentadiene
6. Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter
7. New approach methodologies in human regulatory toxicology – Not if, but how and when!
8. In vitro models to detect in vivo bile acid changes induced by antibiotics
9. A framework for chemical safety assessment incorporating new approach methodologies within REACH
10. Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects
11. Ontogeny of renal, hepatic, and placental expression of ATP-binding cassette and solute carrier transporters in the rat and the rabbit
12. Use of in vitro metabolomics in NRK cells to help predicting nephrotoxicity and differentiating the MoA of nephrotoxicants
13. Uterotrophic and in vitro screening for (anti)estrogenic activity of dipyrone
14. Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat
15. Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
16. Variance of body and organ weights in 28-day studies in mice
17. Xenobiotica-metabolizing enzyme induction potential of chemicals in animal studies: NanoString nCounter gene expression and peptide group-specific immunoaffinity as accelerated and economical substitutions for enzyme activity determinations?
18. Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol®) and the impact upon its toxicity profile
19. Safety assessment of EPA+DHA canola oil by fatty acid profile comparison to various edible oils and fat-containing foods and a 28-day repeated dose toxicity study in rats
20. Uterine adenocarcinoma in the rat induced by afidopyropen. An analysis of the lesion's induction, progression and its relevance to humans
21. A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles
22. Assessment of the analgesic dipyrone as a possible (anti)androgenic endocrine disruptor
23. The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy
24. In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds
25. A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture
26. Lacking applicability of in vitro eye irritation methods to identify seriously eye irritating agrochemical formulations: Results of bovine cornea opacity and permeability assay, isolated chicken eye test and the EpiOcular™ ET-50 method to classify according to UN GHS
27. Assessment of skin sensitization under REACH: A case report on vehicle choice in the LLNA and its crucial role preventing false positive results
28. Use of physiologically based kinetic modeling-facilitated reverse dosimetry of in vitro toxicity data for prediction of in vivo developmental toxicity of tebuconazole in rats
29. Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443)
30. Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
31. Green Toxicology: a strategy for sustainable chemical and material development
32. Flusilazole induces spatio-temporal expression patterns of retinoic acid-, differentiation- and sterol biosynthesis-related genes in the rat Whole Embryo Culture
33. Activities of xenobiotic metabolizing enzymes in rat placenta and liver in vitro
34. Postnatal fate of prenatal-induced fetal alterations in laboratory animals
35. Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers
36. A developmental toxicity study of 3S, 3′S-Astaxanthin in New Zealand white rabbits
37. Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
38. Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny – Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS)
39. Prenatal toxicity of synthetic amorphous silica nanomaterial in rats
40. Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds
41. Investigations on the dose–response relationship of combined exposure to low doses of three anti-androgens in Wistar rats
42. Investigations of putative reproductive toxicity of low-dose exposures to vinclozolin in Wistar rats
43. A protocol to determine dermal absorption of xenobiotica through human skin in vitro
44. Comparing effect levels of regulatory studies with endpoints derived in targeted anti-androgenic studies: example prochloraz
45. Effect of estrogenic binary mixtures in the yeast estrogen screen (YES)
46. Anti-androgenicity can only be evaluated using a weight of evidence approach
47. Editorial: Applying ‘omics technologies in chemicals risk assessment
48. Regulatory accepted but out of domain: In vitro skin irritation tests for agrochemical formulations
49. Connecting Gut Microbial Diversity with Plasma Metabolome and Fecal Bile Acid Changes Induced by the Antibiotics Tobramycin and Colistin Sulfate.
50. Vinclozolin: A case study on the identification of endocrine active substances in the past and a future perspective
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