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By the end of October 2022, the US HL-LHC Accelerator Upgrade Project (AUP) had completed fabrication of ten MQXFA magnets and tested eight of them. The MQXFA magnets are the low-beta quadrupole magnets to be used in the Q1 and Q3 Inner Triplet elements of the High Luminosity LHC. This AUP effort is shared by BNL, Fermilab, and LBNL, with strand verification tests at NHMFL. An important step of the AUP QA plan is the testing of MQXFA magnets in a vertical cryostat at BNL. The acceptance criteria that could be tested at BNL were all met by the first four production magnets (MQXFA03-MQXFA06). Subsequently, two magnets (MQXFA07 and MQXFA08) did not meet some of the criteria and were disassembled. Lessons learned during the disassembly of MQXFA07 caused a revision to the assembly specifications that were used for MQXFA10 and subsequent magnets. In this article, we present a summary of: 1) the fabrication and test data for all the MQXFA magnets; 2) the analysis of MQXFA07/A08 test results with characterization of the limiting mechanism; 3) the outcome of the investigation, including the lessons learned during MQXFA07 disassembly; and 4) the finite element analysis correlating observations with test performance. By the end of October 2022, the US HL-LHC Accelerator Upgrade Project (AUP) had completed fabrication of ten MQXFA magnets and tested eight of them. The MQXFA magnets are the low beta quadrupole magnets to be used in the Q1 and Q3 Inner Triplet elements of the High Luminosity LHC. This AUP effort is shared by BNL, Fermilab, and LBNL, with strand verification tests at NHMFL. An important step of the AUP QA plan is the testing of MQXFA magnets in a vertical cryostat at BNL. The acceptance criteria that could be tested at BNL were all met by the first four production magnets (MQXFA03-MQXFA06). Subsequently, two magnets (MQXFA07 and MQXFA08) did not meet some criteria and were disassembled. Lessons learned during the disassembly of MQXFA07 caused a revision to the assembly specifications that were used for MQXFA10 and subsequent magnets. In this paper, we present a summary of: 1) the fabrication and test data of all the MQXFA magnets; 2) the analysis of MQXFA07/A08 test results with characterization of the limiting mechanism; 3) the outcome of the investigation, including the lessons learned during MQXFA07 disassembly; and 4) the finite element analysis correlating observations with test performance.

The upgrade of the cryogenics for the HL-LHC will consist of the following: • - The design and installation of two new cryogenic plants at P1 and P5 for high luminosity insertions. This upgrade will be based on a new sectorization scheme aimed at separating the cooling of the magnets in these insertion regions from the arc magnets and considering the newt feedboxes and superconducting links located in underground infrastructures. • - The design and installation of a new cryogenic distribution lines (QXL) at P1 and P5 in the LHC tunnel and in a new underground service galleries. • - The upgrade of the existing cryogenic plant (QSRA and QURA) cooling the LHC sector 3-4 located at P4. • - The cryogenic design support for superconducting devices, such as magnets, crab cavities, superconducting links, and the hollow electron lenses. Some other options such as new cryogenic circuits at P7 for the HTS links and displaced current feedboxes or a new cryoplant in P4 have been discarded., CERN Yellow Reports: Monographs, Vol. 10 (2020): High-Luminosity Large Hadron Collider (HL-LHC): Technical design report

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up anew energy frontier for exploration in 2010, it has gathered a global user community of about 9000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its instantaneous luminosity (rate of collisions) by a factor of five beyond the original design valueand the integrated luminosity (totalnumber of collisions) by a factor ten. The LHC is already a highly complexand exquisitely optimised machine so this upgrade must be carefully conceived and will require new infrastructures(underground and on surface)and over a decade to implement. The new configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12Tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 100 metre-long high-power superconducting links with negligible energy dissipation, all of which required several years of dedicated R&D; effort on a global international level. The present document describes the technologies and components that will be used to realise the projectand is intended to serve as the basis for the detailed engineering design of the HL-LHC.

The Superconducting Proton Linac (SPL) is an R&D effort conducted by CERN in partnership with other international laboratories, aimed at developing key technologies for the construction of a multi-megawatt proton linac based on state-of-the-art SRF technology. Such an accelerator could serve as a driver in new physics facilities for neutrinos and/or radioactive ion beams [1]. Amongst the main objectives of this effort, are the development of 704 MHz bulk niobium beta=1 elliptical cavities (operating at 2 K and providing an accelerating gradient of 25 MV/m) and the test of a string of cavities integrated in a machine-type cryo-module. In an initial phase, only four out of the eight cavities of the SPL cryo-module will be tested in a half-length cryo-module developed for this purpose, which nonetheless preserves the main features of the full size module. This paper presents the final design of the cryo-module and the status of the construction of the main cryostat parts. Preliminary plans for the assembly and testing of the cryo-module at CERN are also presented.

For the LHC upgrade projects, CERN will rely on the Nb$_{3}$Sn technology to build high field dipole and quadrupole superconducting magnets. In the frame of this R&D program, cooling studies are carried out to determine the heat extraction from this new type of accelerator magnets and the relevant quench limits. In this paper we present and discuss experimental results of heat transfer through the electrical insulation of Nb$_{3}$Sn cables. A cable-stack was prepared using fiberglass sleeves and CTD-101K impregnation resin. Two different measurement methods were compared, consisting of instrumenting the sample before or after the vacuum impregnation. The tests were performed both in 1.9 K superfluid and 4.2 K liquid helium baths, using different heating configurations. We also present results of the numerical model developed to reproduce the experimental results.

Applied superconductivity has become a key enabling technology for high-energy particle accelerators, thus making them large helium cryogenic systems operating at very low temperature. The circulation of high-intensity particle beams in these machines generates energy deposition in the first wall through different processes. For thermodynamic efficiency, it is advisable to intercept these beam-induced heat loads, which may be large in comparison with cryostat heat in-leaks, at higher temperature than that of the superconducting magnets of the accelerator, by means of beam screens located in the magnet apertures. Beam screens may also be used as part of the ultra-high vacuum system of the accelerator, by sheltering the gas molecules cryopumped on the beam pipe from impinging radiation and thus avoiding pressure runaway. Space being extremely tight in the magnet apertures, cooling of the long, slender beam screens also raises substantial problems in cryogenic heat transfer and fluid flow. We present sizing rules and technical solutions for such beam screens, as applied to the existing Large Hadron Collider (LHC) and its upgrades under study.

The cryogenic system for the CLIC wiggler magnets is under design. The cooldown process is one of the main dimensioning factors for the system. In this paper, the heat transfer model used to simulate the cool-down process is presented. Different configurations are then investigated and a detailed analysis of the corresponding temperature evolutions along the magnet strings is calculated. The temperature profiles are evaluated for the flowing helium as well as for the magnets allowing a detailed analysis of the temperature gradients. The impact of some key parameters, like the mass-flow rate, the diameter of the cooling channels and of the thermal coupling between the helium and the magnets is also investigated.

The LHC is operating with beam since end 2009. However, with the present interaction region magnets it cannot reach its nominal performance and a phased approach to upgrading them to reach that nominal performance is taken. The first phase of the LHC interaction region upgrade was approved by Council in December 2007. This phase relies on the mature Nb-Ti superconducting magnet technology with the target of increasing the LHC luminosity to 2 to 3×1034 cm-2s-1, while relying on the existing infrastructure which limits the total heat removal capacity at 1.9 K to 500 W. The Phase I Upgrade LHC interaction region final focus magnets will include four superconducting quadrupoles (low-β triplets) and one superconducting dipole (D1) cooled with pressurized, static superfluid helium (HeII) at 1.9 K. The heat absorbed in pressurized HeII, which may be more than 30 W/m due to dynamic heating from the particle beam halo, will be conducted to saturated He II at about 1.9 K and removed by the low pressure vapour. This paper discusses the conceptual design for the cryogenics of the Phase I Upgrade interaction region superconducting magnets and the integration of this magnet system into the overall LHC cryogenic system

The Large Hadron Collider (LHC) cryogenic system was progressively and successfully run for the LHC accelerator operation period starting from autumn 2009. The paper recalls the cryogenic system architecture and main operation principles. The system stability during magnets powering and availability periods for high energy beams with first collisions at 3.5 TeV are presented. Treatment of typical problems, weak points of the system and foreseen future consolidations will be discussed.

The LHC is starting operation with beam. The primary goal of CERN and the LHC community is to ensure that the collider is operated efficiently and that it achieves nominal performance in the shortest term. Since several years the community has been discussing the directions for maximizing the physics reach of the LHC by upgrading the experiments, in particular ATLAS and CMS, the LHC machine and the CERN proton injector complex, in a phased approach. The first phase of the LHC interaction region upgrade was approved by Council in December 2007. This phase relies on the mature Nb-Ti superconducting magnet technology with the target of increasing the LHC luminosity to 2 to 3 10^34 cm^-2s^-1, while maximising the use of the existing infrastructure. In this report, we present the goals and the proposed conceptual solutions for the LHC IR Upgrade Phase-I which include the recommendations of the conceptual design review.

The Large Hadron Collider (LHC) requires distribution of high electrical currents in the limited space of LHC tunnel. Four superconducting links of about 76 m length and one of 510 m will be installed in the tunnel to carry 6Â kA and 600 A. For validation of the longest link a test station was designed which is presently under construction. The design will permit the test station to be adapted for other links and/or cables as well. It will operate either in pool boiling mode, in order to measure thermal loads, or in forced super-critical helium flow mode to simulate real operation. Inlet pressure is 1.2 bar to 3 bar. Inlet temperature is adjustable from 4.4 K up to about 20 K. The station is being prepared to validate the LHC model link, consisting of 48 superconducting cables, each operating at 600 A between 4.5 K and 5.4 K. This article describes features of the equipment.

The paper discusses the main constraints and boundary conditions and describes the baseline configuration of the International Linear Collider (ILC) cryogenic system. The cryogenic layout, architecture and the cooling principle are presented. The paper addresses a plan for study and development required to demonstrate and improve the performance, to reduce cost and to attain the desired reliability.

Recent experiments conducted with a co-current flow of saturated superfluid helium at CEA-Grenoble have shown a transition from stratified two phase flow to droplet mist flow at high vapor velocities. The two phase co-current stratified flow was circulated through a 40 mm inner diameter, 10 m long tube, with a slope ranging between 0 and 1.4%. Mass flow rates and temperatures ranged between 1 and 7 g/s, 1.8 and 2 K respectively. These various conditions allowed a comparison of the flow behavior for same void fraction but different vapor mass flows. Some evidences of atomization without any transition from stratified to annular flow are given.

After the commissioning of String 2 Phase1 and the powering of the main circuits in autumn 2001, a short yet vigorous experimental program was carried-out to validate the final design choices for the technical systems of LHC. This program included the investigation of thermo-hydraulics of quenches quench propagation, power converter controls and tracking between power converters, as well as the measurement of currents induced in the beam screen after a quench and crossing the interconnects. Parameters significant for the LHC, such as heat loads, were also measured. During the winter shutdown the String was completed to a full cell with the addition of three pre-series dipoles (Phase 2). After a short description of the layout of Phase 1 and Phase 2, the results of the experiments are presented and the future experimental program is outlined.

The LHC development program relies on cryogenic tests of prototype and model magnets. This vigorous program is pursued in a dedicated test facility based on several vertical cryostats working at superfluid helium temperatures. The performance of the facility is detailed. Goals and test equipment for currently performed studies are reviewed: quench analysis and magnet protection studies, measurement of the field quality, test of ancillary electrical equipment like diodes and busbars. The paper covers the equipment available for tests of prototypes and some special series of LHC magnets to come.

Brookhaven National Laboratory (BNL) will provide four types of magnets, identified as D1, D2, D3 and D4, for the Insertion Regions of the Large Hadron Collider (LHC) as part of an international collaboration. These magnets utilize the dipole coil design of the Relativistic Heavy Ion Collider (RHIC) at BNL, for performance, reliability and cost reasons. The magnet cold mass and cryostat have been designed to ensure that these magnets meet all performance requirements in the LHC sloped tunnel using its cryogenic distribution system. D1 is a RHIC arc dipole magnet. D2 and D4 are 2-in-1 magnets, two coils in one cold mass, in a cryostat. D3 is a 1-in-1 magnet, one coil in one cold mass, with two cold masses side by side in a cryostat. D1 and D4 will be cooled by helium II at 1.9 K using a bayonet heat exchanger similar to the main cooling system of LHC. D2 and D3 will be cooled by liquid helium at 4.5 K using a Two-Feed scheme. A detailed description of the cooling scheme for these magnets, their cryostats, special features and interfaces with the LHC distribution system is given.

The LHC magnet cooling scheme is based on a HeII bayonet heat exchanger, which acts as a quasi isothermal heat sink. In order to assess the thermal performance of the oxygen free, annealed/cold worked copper tube, measurements of the total thermal conductance of the tube were performed in a laboratory set-up. This paper describes the experimental technique, which permits to separate the contributio n of the Kapitza interface resistance from the total transverse conductance. The influence of the surface treatment on the Kapitza resistance is also discussed.

Future large devices using superconducting magnets or RF cavities (e.g. LHC or TESLA) need He II two-phase flow for cooling. The research carried out into counter-current superfluid two-phase flow was the continuation of work on co-current flow and benefited from all the knowledge acquired both experimentally and theoretically. Experiments were conducted on two different pipe diameters (40 and 65 m m I.D. tube) for slopes ranging between 0 and 2%, and for temperatures ranging between 1.8 and 2 K. This paper introduces the theoretical model, describes the tests, and provides a critical review of the results obtained in He II counter current two-phase flow.

Since the end of 1994 we have been operating a prototype half-cell of the machine lattice, accumulating more than 10,000 hours at superfluid helium temperatures and recovering from 150, mainly provoke d, magnet resistive transitions. The system has confirmed the validity of the basic design choices of the LHC cryogenic system. Furthermore, extensive testing on the response of the system to current ramp and discharge, and to magnet resistive transition, has provided sufficient information to enable a simplification of the cryogenic scheme that fulfils the LHC requirements. We report on the cryog enic operation, testing and long-term behaviour of the LHC Test String during the last 4 years of operation.

In preparation for the Large Hadron Collider project, a 42.5 m-long prototype superconducting magnet string, representing a half-cell of the machine lattice, has been built and operated. A series of tests was performed to assess the thermohydraulics of resistive transitions (quenches) of the superconducting magnets. These measurements provide the necessary foundation for describing the observed evolution of the helium in the cold mass and formulating a mathematical model based on energy conservation. The evolution of helium after a quench simulated with the model reproduces the observations. We then extend the simulations to a full LHC cell, and finally analyse the recovery of helium discharged from the cold mass.

BACKGROUND: In addition to treatment response, cytogenetic and molecular aberrations are the most important prognostic factors in children with de novo acute myeloid leukemia (AML). However, little is known about cytogenetics at the time of relapse.METHODS: This international study analyzed the prognostic value of cytogenetic profiles and karyotypic changes in pediatric relapsed AML in relation to the probability of event-free (pEFS) and overall survival (pOS). For this purpose, cytogenetic reports from all patients registered on the Relapsed AML 2001/01 Study were reviewed and classified.RESULTS: Cytogenetic information at relapse was available for 403 (71%) of 569 registered patients. Frequently detected aberrations at relapse were t(8;21)(q22;q22) (n = 60) and inv(16)(p13.1q22)/t(16;16)(p13.1;q22) (n = 24), both associated with relatively good outcome (4-year pOS 59% and 71%, respectively). Monosomy 7/7q-, t(9;11)(p22;q23), t(10;11)(p12;q23), and complex karyotypes were associated with poor outcomes (4-year pOS 17%, 19%, 22%, and 22%, respectively). Of 261 (65%) patients for whom cytogenetic data were reliable at both diagnosis and relapse, pEFS was inferior for patients with karyotypic instability (n = 128, 49%), but pOS was similar. Unstable karyotypes with both gain and loss of aberrations were associated with inferior outcome. Early treatment response, time to relapse, and cytogenetic profile at time of relapse were the most important prognostic factors, both outweighing karytoypic instability per se.CONCLUSION: The cytogenetic subgroup at relapse is an independent risk factor for (event-free) survival. Cytogenetic assessment at the time of relapse is of high importance and may contribute to improved risk-adapted treatment for children with relapsed AML.