317 results on '"van der Stelt, Mario"'
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2. A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
3. Structural basis of selective cannabinoid CB2 receptor activation
4. Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor
5. Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain
6. Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity.
7. P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism.
8. Structure–Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors.
9. Discovery of a Cannabinoid CB2 Receptor Fluorescent Probe Based on a Pyridin-2-yl-benzyl-imidazolidine-2,4-dione Scaffold.
10. Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala
11. Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor.
12. IMI European Lead Factory — democratizing access to high-throughput screening
13. PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells
14. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
15. Improving CLL Vγ9Vδ2-T–cell fitness for cellular therapy by ex vivo activation and ibrutinib
16. Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
17. Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory
18. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
19. CB1 Cannabinoid Receptors and On-Demand Defense against Excitotoxicity
20. Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis
21. Disruption of tonic endocannabinoid signalling triggers cellular, behavioural and neuroendocrine responses consistent with a stress response.
22. A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance.
23. Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders
24. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
25. EFMC - trends that link medicinal chemistry and chemical biology to translational drug discovery
26. Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells
27. Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery
28. Evaluation of different drug classes on transient sciatic nerve injury–depressed marble burying in mice
29. Chemical tools to modulate 2‐arachidonoylglycerol biosynthesis
30. The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases
31. EFMC: Trends in Medicinal Chemistry and Chemical Biology.
32. Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes
33. Understanding and Targeting the Endocannabinoid System with Activity‐Based Protein Profiling.
34. Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta.
35. 2-AG-Mediated Control of GABAergic Signaling Is Impaired in a Model of Epilepsy.
36. Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.
37. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes
38. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity
39. Chemical Probes to Control and Visualize Lipid Metabolism in the Brain.
40. Comparative Photoaffinity Profiling of Omega‑3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages.
41. Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates.
42. Peripherally Restricted, Selective Cannabinoid CB2 Receptor Agonist LEI-101 Prevents Cisplatin-Induced Nephrotoxicity by Attenuating Oxidative/Nitrative Stress and Inflammation: 200
43. Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437.
44. Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role in Gut Barrier Integrity.
45. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
46. Cannabinoid receptors and their role in neuroprotection
47. Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases
48. Acute neuronal injury, excitotoxicity, and the endocannabinoid system
49. Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy.
50. The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization
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