1. Influence des propriétés physicochimiques d'hydroxyapatites sur le comportement cellulaire
- Author
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Laquerriere, P., Grandjean-Laquerriere, A., Jallot, E., Nardin, M., Frayssinet, P., Nedelec, J.-M., and Laurent-maquin, D.
- Subjects
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CELLS , *PLASTIC surgery , *ISOSTATIC pressing , *POWDER metallurgy , *SINTERING , *ORTHOPEDIC implants , *BONE substitutes , *OPERATIVE surgery , *OLD age , *LEUCOCYTES , *KILLER cells , *INFLAMMATORY mediators - Abstract
Abstract: Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation into possible wear particles from materials used in the implant may lead to increase the longevity of implants after arthroplasty. In the present paper, we discussed the cellular response (mainly monocytes/macrophages which are among the first cells to colonize the inflammatory site in addition to osteoblats and fibroblasts) after exposition to particles with different characteristics (size, sintering temperature, shape, and chemical composition). The most important characteristics are the shape and the size of the particles. The needle shaped particles induced the larger production of inflammatory mediators by cells and were more toxic. The sintering temperature appeared to be a less important characteristic even though it was involved in the dissolution/precipitation process. Little is known about the effect of ion containing hydroxyapatite (like zinc, strontium, …) on cellular response but this modification of the biomaterial seems benefic. [Copyright &y& Elsevier]
- Published
- 2005
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