1. Inhibitors of HIV-1 Nef: applications and developments for a practical cure.
- Author
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Lurie, Antony, Fink, Corby, Gosselin, Geneviève, Dekaban, Gregory A., and Dikeakos, Jimmy D.
- Subjects
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HIV , *T cell receptors , *HIV-positive persons , *ANTIRETROVIRAL agents , *ANTIGEN presentation - Abstract
Antiretroviral therapy can control human immunodeficiency virus type 1 (HIV-1) replication in people living with HIV; however, these treatments are not curative and no practical approach for an HIV-1 cure has yet shown success in clinical trials. Counteracting the multiple barriers HIV-1 presents against a practical cure is a direct means to functionalize these curative approaches in vivo. Pharmacological inhibition of the HIV-1 accessory protein, Nef, represents a particularly promising and ambitious approach, with Nef inhibitors holding the potential to reverse HIV-1-related defects in T cell receptor and kinase signaling, apoptosis, autophagy and most importantly, antigen presentation. Together, the capacity for Nef inhibitors to restore these activities underscores their potential as supportive agents in a practical HIV-1 cure. In this review, we outline a rationale for pharmacologically targeting Nef and review the progress made in the identification and development of Nef inhibitors. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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