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First toxoplasma infection diagnosis during macrophage activation syndrome (MAS), treated by chemotherapy by étoposide. A month later appears a supraclavicular lymphadenopathy, the pathological examination find a T anaplastic lymphoma ALK+. Does the toxoplasmosis infection complicate it with MAS that empowers by T lymphoma? Or the patient had a latent T lymphoma, which was revealed by a MAS induced by a toxoplasmosis? [ABSTRACT FROM AUTHOR]

Primary therapy for high-risk gestational trophoblastic neoplasia (GTN) includes a multi-agent, methotrexate-based regimen, named EMA/CO. In France, the guidelines recommend the use of either a platinum-based protocol when methotrexate is contra-indicated or a highdose EMA/CO once brain metastases are diagnosed. For patients who are resistant to the initial therapy, different salvage approaches have been developed or adapted from treatments already used for germ cell tumors. Currently, the most frequently used protocol is a combination of etoposide and platinum-based therapy (EMA/EP). In the EMA/EP protocol, etoposide and cisplatin are used in place of cyclophosphamide and vincristine (CO in the EMA/CO regimen) with the goal of reversing resistance mechanisms of previously used drugs. Although, new approaches for improving the management of high-risk patients who are resistant or refractory to the initial therapy are now available, new molecules are still awaited to optimize patient's care. [ABSTRACT FROM AUTHOR]

Summary: The association of hemophagocytic syndrome (HS) and visceral leishmaniasis is a frequent disorder during infancy in endemic areas such as Tunisia. The range of severity of HS secondary to visceral leishmaniasis includes both pure biological forms that resolve with antimicrobial therapy and life-threatening emergencies that require specific treatment. We describe 2 cases of severe HS secondary to visceral leishmaniasis. The diagnosis of HS was based on the HLH-2004 diagnostic criteria. Therapy involved pentavalent antimonial (Glucantime®) in both cases. The combination of corticosteroids with immunoglobulins, used in the 1st case, but introduced late, led to an unfavorable course and death. In the 2nd case, the specific treatment of HS was based on immunochemotherapy including etoposide and corticosteroids. Progression was favorable with a follow-up of 24 months. Etoposide containing therapeutic regimens can be proposed in severe forms of HS associated with visceral leishmaniasis. [ABSTRACT FROM AUTHOR]

Abstract: We report the case of a 66-year-old patient with a pilomatrix carcinoma from the right submandibular region with pulmonary and cerebral metastases. The histological confirmation of the diagnosis has been based on the biopsy of the submandibular tumefaction which was rapidly growing. We tried at first a doxorubicine and cisplatine chemotherapy because of the considerable locoregional extension and the existence of pulmonary metastases. The patient response to three cures of chemotherapy was spectacular with a partial clinical response (75%) and a partially cleaned-up chest observed in the radiological evaluation. In the 5th cycle of chemotherapy following the same protocol, the patient presented a relapse with cerebral metastases. The patient received hypofractionated radiotherapy on the brain followed by etoposide and cisplatine chemotherapy, then oral vinorelbine. The patient died of progressive disease after 32 weeks. [Copyright &y& Elsevier]