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The previous study has researched that combining YKL-5-124, CDK7 specific target drug with anti-PD-1 treatment had a survival advantage in various Small Cell Lung Cancer models. However, the molecular mechanism that YKL-5-124 triggers inflammatory response remains unknown. This study investigates the effects of CDK7 inhibition by YKL-5-124 on two DNA damage pathways (ATM and ATR) of SCLC in vitro. The result of this study will reveal the effects of CDK7 inhibition by YKL-5-124 on the molecular mechanisms of SCLC and potentially promote the development of new anticancer treatment strategies based on immunity manipulation.

Based on the analysis of traditional state maintenance strategy and big data-based state maintenance strategy, this paper builds a transformer state duration simulation model based on Monte Carlo method and builds an annual cost model based on the running state of the transformer. Finally, a typical case is selected to simulate a time series of 8760 hours of transformer operation under two operational inspection strategies, and the annual cost is calculated separately. The example shows that the annual cost of the transformer is lower under the big data-based inspection strategy.