1. N-6 fatty acids and cardiovascular health: dietary intake recommendations
- Author
-
Czernichow, Sébastien, Thomas, Daniel, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Hôpital Ambroise Paré [AP-HP], CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
RISK ,DENSITY-LIPOPROTEIN CHOLESTEROL ,SATURATED FAT ,[SDV]Life Sciences [q-bio] ,WOMEN ,lipids (amino acids, peptides, and proteins) ,CORONARY-HEART-DISEASE ,BLOOD-PRESSURE ,MEN ,ASSOCIATION ,LINOLEIC-ACID ,METAANALYSIS - Abstract
National audience; N-6 fatty acids and cardiovascular health: dietary intake recommendations Omega-6 polyunsaturated fatty acids (n-6 PUFA) are well known for their critical role in many physiological functions and reduce risks of cardiovascular disease (CVD). However, some argue that excessive consumption of n-6 PUFA may lead to adverse effects on health and therefore recommend reducing dietary n-6 PUFA intake or fixing an upper limit. Epidemiological studies show that n-6 PUFA dietary intake significantly lowers blood LDL-cholesterol levels. In addition, n-6 PUFA intake lower several cardiovascular risk factors such as blood pressure, inflammatory markers, haemostatic parameters and obesity. Data from prospective cohort and interventional studies converge towards a specific protective role of dietary n-6 PUFA intake, in particular linoleic acid, against CVD. In regards to studies examined in this narrative review, recommendation for n-6 PUFA intake above 5%, and ideally about 10% of total energy appears justified for the prevention of ischemic heart disease.
- Published
- 2011