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Your search keyword '"Cefoxitin metabolism"' showing total 5 results
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5 results on '"Cefoxitin metabolism"'

1. [Diffusion of cefotaxime in the interstitial fluid of rabbits. Comparison with cefazolin, cefoxitin and cefamandole (author's transl)].

Author

Boussougant Y, Contrepois A, Doquir C, and Carbon C

Subjects
Animals, Cefamandole metabolism, Cefazolin metabolism, Cefotaxime, Cefoxitin metabolism, Diffusion, Rabbits, Cephalosporins metabolism, Extracellular Space metabolism
Abstract

The diffusion of cefotaxime compared with that of cefazolin, cefoxitin and cefamandole in the interstitial fluid has been studied in rabbits. The different antibiotics were administered intramuscularly at a dose of 30 mg/kg by injection. Serum concentrations were determined at 30 minutes, 2, 4, 8 and 12 hours following the injection.

Published
1981

2. [Study of the transperitoneal passage of cefoxitin in the ascitic cirrhotic patient].

Author

Bourreille J, Le Bihan G, Beau B, Leroy A, Humbert G, and Barthes PX

Subjects
Aged, Ascites etiology, Cefoxitin administration & dosage, Cefoxitin therapeutic use, Female, Humans, Kinetics, Liver Cirrhosis, Alcoholic complications, Male, Middle Aged, Ascites metabolism, Ascitic Fluid metabolism, Cefoxitin metabolism
Published
1979

3. [Pharmacokinetic study of antibiotics in human respiratory tract (author's transl)].

Author

Bergogne-Berezin E, Morel C, Even P, Benard Y, Kafe H, Berthelot G, Pierre J, and Lambert-Zechovsky N

Subjects
Adult, Aged, Amikacin metabolism, Amoxicillin metabolism, Anti-Bacterial Agents therapeutic use, Bronchitis drug therapy, Cefoxitin metabolism, Female, Humans, Kinetics, Male, Middle Aged, Oleandomycin metabolism, Anti-Bacterial Agents metabolism, Bronchi metabolism
Abstract

We report the results of the study of the bronchial concentrations of several antibiotics. The experiment included 280 patients and the concentrations achieved in bronchial secretions were measured for 11 antibiotics. The samples of bronchial secretions were taken in situ by fibroscopy or through the tracheostomy cannula. The results of the study show that the rate of penetration is variable according to the different drugs; even in the same antibiotic family such as beta-lactam antibiotics the rate of penetration is variable. The bronchial levels of aminoglycosides, macrolides and tetracyclines are worthwhile, and are often superior to the MIC of the infecting organisms; the penetration is also dependant of the inflammatory conditions of the bronchi. Otherwise the sampling conditions were the best possible since samples taken by fibroscopy or by tracheostomy are not contaminated by saliva which is a factor of dilutional error. The methodology used in this study is an approach of pharmacokinetics of antibiotics in respiratory tract.

Published
1978

4. [Study of transplacental transmission of beta-lactam antibiotics (author's transl)].

Author

Bergogne-Berezin E, Lambert-Zechovsky N, and Rouvillois JL

Subjects
Amniotic Fluid analysis, Female, Fetal Blood analysis, Fetal Membranes, Premature Rupture complications, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious etiology, Pregnancy Complications, Infectious prevention & control, Time Factors, Amoxicillin metabolism, Cefoxitin metabolism, Cephalosporins metabolism, Cephradine metabolism, Maternal-Fetal Exchange
Abstract

The authors present the results of the study of transplacental transfer of 3 recent beta lactam antibiotics: amoxicillin, cephradin and cefoxitin. The experiment was carried out in 37 pregnant women who had a premature rupture of membranes or who were undergoing a cesarean section. In these patients antibiotherapy was indicated in view of a possible superinfection. The results of the study show a worthwhile transplacental penetration of the 3 drugs tested. The concentrations achieved in umbilical cord blood and amniotic fluid increase with time and finally exceed the levels measured in maternal blood, after a period of time varying from 2 to 4 hours according to the drug and the route of administration.

Published
1979

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