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3 results on '"Ch Sultan"'

1. [The androgen receptor: molecular pathology]

Author

Ch, Sultan, J, Gobinet, B, Terouanne, F, Paris, Ch, Belon, S, Jalaguier, V, Georget, N, Poujol, G, Auzou, and S, Lumbroso

Subjects
Male, Models, Molecular, Chromosomes, Human, X, Genotype, Transcription, Genetic, Protein Conformation, DNA Mutational Analysis, Active Transport, Cell Nucleus, Prostatic Neoplasms, DNA, Adenocarcinoma, Androgen-Insensitivity Syndrome, Structure-Activity Relationship, Phenotype, Gene Expression Regulation, Receptors, Androgen, Androgens, Humans, Infertility, Male, Signal Transduction, Transcription Factors
Abstract

Androgens play a crucial role in the development, maintenance and regulation of male phenotype and reproductive physiology through the androgen receptor, a transcription factor. Testosterone or dihydrotestosterone binding induces a trans-conformation of the androgen receptor and allows its translocation into the nucleus, where it recognizes specific DNA sequences. Recent developments in molecular genetics, as well as structural analysis of the androgen receptor, allow a better understanding of the structure/function relationship of this nuclear receptor. Molecular analyses of androgen insensitivity syndrome, as well as hormone-resistant prostate cancer, Kennedy's disease and isolated male infertility, have been proved useful as privileged models for this purpose. In the absence of identified AR receptor mutations in androgen insensitivity syndromes, abnormalities of transcriptional cofactor should be considered. Finally, identification of androgen-dependent genes will be helpful for evaluating the degree of the molecular defect of androgen action within target cells.

Published
2002

2. L'évaluation de la maturation des os du carpe par analyse d'image : une alternative à l'âge osseux ou un outil complémentaire ?

Author

François Bonnel, Marc Jaeger, Ch. Sultan, A. Dimeglio, and F. Canovas

Subjects
musculoskeletal diseases, education.field_of_study, Bone density, business.industry, U10 - Informatique, mathématiques et statistiques, Radiography, Population, 000 - Autres thèmes, Wrist, Skeleton (computer programming), body regions, Carpal bones, medicine.anatomical_structure, Skeletal maturation, X ray computed, Pediatrics, Perinatology and Child Health, medicine, L52 - Physiologie animale - Croissance et développement, U30 - Méthodes de recherche, education, business, Nuclear medicine
Abstract

L'évaluation radiographique de la maturation osseuse assistée ou non par ordinateur repose sur la comparaison entre l'aspect radiographique d'un segment de membre d'un enfant avec l'aspect standardisé dans une population comparable d'enfants à différents stades de maturation. L'évaluation de la maturation osseuse par analyse d'image à partir d'examens tomodensitométriques du poignet est une méthode quantitative permettant de mesurer séparément pour chaque os du carpe le volume, les axes d'inertie et la densité moyenne. Les modifications morphologiques des os du carpe pendant la croissance sont caractérisées par des données quantitatives à partir de la longueur des axes d'inertie et des volumes. L'analyse d'image est une méthode d'avenir pour l'évaluation de la maturation osseuse pendant la croissance. © 2000 Éditions scientifiques et médicales Elsevier SAS

Published
2000

3. [The androgen receptor: molecular pathology].

Author

Sultan Ch, Gobinet J, Terouanne B, Paris F, Belon Ch, Jalaguier S, Georget V, Poujol N, Auzou G, and Lumbroso S

Subjects
Active Transport, Cell Nucleus, Adenocarcinoma genetics, Adenocarcinoma metabolism, Androgen-Insensitivity Syndrome diagnosis, Androgen-Insensitivity Syndrome genetics, Androgen-Insensitivity Syndrome physiopathology, Androgens physiology, Chromosomes, Human, X genetics, DNA metabolism, DNA Mutational Analysis, Gene Expression Regulation physiology, Genotype, Humans, Infertility, Male etiology, Male, Models, Molecular, Phenotype, Prostatic Neoplasms genetics, Prostatic Neoplasms metabolism, Protein Conformation, Receptors, Androgen chemistry, Receptors, Androgen deficiency, Receptors, Androgen genetics, Signal Transduction, Structure-Activity Relationship, Transcription Factors physiology, Transcription, Genetic, Receptors, Androgen physiology
Abstract

Androgens play a crucial role in the development, maintenance and regulation of male phenotype and reproductive physiology through the androgen receptor, a transcription factor. Testosterone or dihydrotestosterone binding induces a trans-conformation of the androgen receptor and allows its translocation into the nucleus, where it recognizes specific DNA sequences. Recent developments in molecular genetics, as well as structural analysis of the androgen receptor, allow a better understanding of the structure/function relationship of this nuclear receptor. Molecular analyses of androgen insensitivity syndrome, as well as hormone-resistant prostate cancer, Kennedy's disease and isolated male infertility, have been proved useful as privileged models for this purpose. In the absence of identified AR receptor mutations in androgen insensitivity syndromes, abnormalities of transcriptional cofactor should be considered. Finally, identification of androgen-dependent genes will be helpful for evaluating the degree of the molecular defect of androgen action within target cells.

Published
2002

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