1. [Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues].
- Author
-
Jordheim LP, Galmarini CM, and Dumontet C
- Subjects
- Antimetabolites, Antineoplastic therapeutic use, Apoptosis, Cladribine metabolism, Cladribine therapeutic use, Cytarabine metabolism, Cytarabine therapeutic use, Deoxycytidine metabolism, Deoxycytidine therapeutic use, Deoxycytidine Kinase metabolism, Humans, Phosphorylation, Vidarabine metabolism, Vidarabine therapeutic use, Gemcitabine, Antimetabolites, Antineoplastic metabolism, Deoxycytidine analogs & derivatives, Drug Resistance, Neoplasm physiology, Nucleoside Transport Proteins metabolism, Nucleosides metabolism, Vidarabine analogs & derivatives
- Abstract
Cytotoxic nucleoside analogues are widely used in treatment of patients with hematological malignancies as well as for some solid tumors. Resistance developed against these molecules limit their clinical use. Many studies on cell models and clinical samples have identified cellular mechanisms involved in this phenomenon. Here, we describe the available data concerning the proteins involved in the metabolism and the mechanism of action of nucleoside analogues, as well as the clinical studies showing their implication in the resistance to these drugs.
- Published
- 2005