1. [Progressive paralysis of the diaphragm following intra-abdominal chemotherapy].
- Author
-
Guinard S, Olland A, Ohana M, Falcoz PE, Kessler R, and Massard G
- Subjects
- Combined Modality Therapy adverse effects, Diaphragm drug effects, Diaphragm pathology, Fatal Outcome, Female, Humans, Hyperthermia, Induced adverse effects, Infusions, Parenteral, Middle Aged, Respiratory Paralysis diagnosis, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Carcinoma therapy, Peritoneal Neoplasms therapy, Respiratory Paralysis chemically induced
- Abstract
Introduction: In patients presenting with intra-abdominal tumor and peritoneal carcinomatosis, cytoreductive surgery associated with hyperthermic chemotherapy may offer improved survival. We describe a case of diaphragmatic paralysis following that kind of procedure., Case Report: A 60-year-old woman presented with respiratory insufficiency following cytoreductive surgery and intra-abdominal hyperthermic chemotherapy performed for pseudomyxoma intraperitonei. Pulmonary function assessment demonstrated a restrictive pattern. Three successive chest CT-scans demonstrated a thinning diaphragm muscle. Respiratory insufficiency eventually led to the death of our patient., Conclusion: We conclude in favor of a muscular degeneration of the diaphragm consecutive to the combined effect of cytoreductive surgery and intraperitoneal chemotherapy. Owing to the unusual nature of this complication, we did not consider it as a hypothesis at an early point in this patient's management. We think physicians should be aware of such a complication in order to consider it in a timely way. We recommend performing a biopsy of the diaphragm for pathology examination to assess muscular degeneration., (Copyright © 2016 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF