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Purpose: To report cases of sexually transmitted infections (STIs) in consultation and evaluate syndromic management., Patients and Methods: We carried out a prospective and descriptive study in patients who had consulted for STI at the urology department of the Gabriel Toure University Hospital from April 2013 to March 2014., HIV cases were not included. The syndromic approach was used., Results: We obtained the following results: 460 cases of STI (Dysuria, Cystitis, Scrotal swelling, Prostatitis). The sex ratio was 20.52 in favor of the male sex. The age group 23-32 years was the most affected, and non-married single patients were the most represented. The majority were Bambara. All cases were diagnosed clinically. Additional tests were requested to confirm the diagnosis. In terms of syndromic management, probabilistic antibiotic therapy was applied to each type of STI. Antibiotic therapy was rehabilitative with an effective therapeutic response in 61.61% of cases for prostatitis, 98.60% for urethritis, 100% for scrotal swelling, 90.78% for cystitis., Conclusion: Management of STIs using the syndromic approach is an option in countries where laboratory diagnosis is not always available., (Le comitée de rédaction se réserve le droit de revoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de sonserver un examplaire du manuscrit, des figures et des tableaux.)