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1. [Opiate receptor(s) of the frog brain: soluble-phase separation of the macromolecular complexes of an agonist and an antagonist].

Author

Puget A and Meunier JC

Subjects
Animals, Centrifugation, Density Gradient methods, Digitonin pharmacology, Diprenorphine pharmacology, Etorphine pharmacology, Macromolecular Substances, Ranidae, Receptors, Opioid drug effects, Solubility, Brain metabolism, Receptors, Opioid isolation & purification
Abstract

Frog brain membranes, pre-labelled with the opiate agonist 3H-etorphine or with the opiate antagonist 3H-diprenorphine, are solubilized with digitonin. The soluble digitonin extract is centrifuged in linear sucrose gradients. Under these conditions, we separate an agonist macromolecular complex and an antagonist macromolecular complex, the former sedimenting faster than does the latter. This difference in apparent molecular size might reflect an agonist-induced coupling between opiate receptor and other membrane components.

Published
1983

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