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5 results on '"F. Schmidt"'

1. Synthese d'ynamines fonctionnalisees en β de la triple liaison et stereoselectivite de l'hydrolyse des cycloadduits formes avec la cyclopentenone et les lactones α-β insaturees

Author

Jean d'Angelo, J Finici, A Guingant, F. Schmidt, J Berlan, SCHMIDT, Frédéric, Chimie biologique des membranes et ciblage thérapeutique (CBMCT - UMR 3666 / U1143), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)

Subjects
Cyclopentenone, chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, [SDV]Life Sciences [q-bio], Organic Chemistry, 010402 general chemistry, Ring (chemistry), Triple bond, 01 natural sciences, Biochemistry, Cycloaddition, 3. Good health, 0104 chemical sciences, Adduct, [SDV] Life Sciences [q-bio], chemistry.chemical_compound, chemistry, Drug Discovery, [CHIM] Chemical Sciences, Alkoxy group, [CHIM]Chemical Sciences, Stereoselectivity, Lactone, ComputingMilieux_MISCELLANEOUS
Abstract

Ynamine 3 reacts with cyclopentenone and lactone 5 by cycloaddition to afford adducts 7 and 4 the hydrolysis of which steroselectivity controlled. The presence of the alkoxy group in β position of the triple bond does not interfere neither with the process of cycloaddition nor the high stereoselectivity of the hydrolysis of cyclobutanone enamines annulated with a five or a six membered ring.

Published
1982
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3. Voir et interpréter les signes du dieu : une apparition de Mandoulis au temple de Kalabchah (Nubie)

Author

Tallet, Gaëlle, Centre de Recherche Interdisciplinaires en Histoire, Histoire de l'Art et Musicologie (CRIHAM), Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université de Poitiers, Georgoudi, R. Koch-Piettre et F. Schmidt, Université de Poitiers-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)

Subjects
[SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

4. L'espace de l'archéologue : l'exemple de Sion

Author

Desreumaux, Alain, Équipe Mondes sémitiques (OM-MS), ORIENT ET MÉDITERRANÉE : Textes, Archéologie, Histoire (OM), Université Paris 1 Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), A. DESREUMAUX & F. SCHMIDT, and Desreumaux, Alain Jacques Paul

Subjects
archéologie, [SHS.HIST] Humanities and Social Sciences/History, Sion, [SHS.HIST]Humanities and Social Sciences/History
Abstract

espace de l'archéologue

Published
1988

5. [Glucuronyl paclitaxel (Taxol) derivatives as tumor activated prodrugs].

Author

Bouvier E, Schmidt F, and Monneret C

Subjects
Animals, Antineoplastic Agents, Phytogenic chemical synthesis, Biotransformation, Humans, Neoplasms metabolism, Paclitaxel chemical synthesis, Antineoplastic Agents, Phytogenic pharmacology, Neoplasms drug therapy, Paclitaxel analogs & derivatives, Paclitaxel pharmacology, Prodrugs
Abstract

Three glucuronyl prodrugs of paclitaxel have been synthesized in order to be activated by the B-glucuronidase present within the necrotic areas of tumors. As three compartments containing prodrugs, they include a specifier, a self immolative spacer and the drug. In vitro testing clearly indicates that the two former prodrugs are stable and are more or less detoxified. As expected, in the presence of E. coli B-glucuronidase, the glycosidic linkage is hydrolyzed with a rate depending on the nature of the spacer but, once this hydrolysis has occurred, the self immolative spacer is soon eliminated leading to the liberation of the paclitaxel.

Published
2005
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