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The present study aims to evaluate the antiinflammatory power of the various crude extracts (aqueous, hydro-methanolic, hydro-acetonic) obtained after maceration of the powders of the fruit peel of Punica granatum. For this very specific purpose, a quantitative phytochemical analysis as well as a cytotoxicity study of the extracts have been shown to be necessary. The results obtained showed a significant extraction yield estimated at 40% for the water/acetone extract. The determination of the total polyphenols and flavonoids revealed values of the order of 29.91 mg EAG/g and 1.515 mg EC/g, respectively, in the water/methanol extract, and the content is higher than the other extracts tested. The toxicity analysis, carried out using the in vitro spectrophotometric method, made it possible to ensure that our three extracts of the fruit peel of Punica granatum L. have a very low level of toxicity, which is considered harmless compared to diclofenac. These results allowed us to safely begin the evaluation of the anti-inflammatory activity of our three prepared extracts. The results obtained show that our three extracts have significant anti-inflammatory capacities ranging from 90 to 100% and are comparable to the protective effect of the reference molecule, namely diclofenac. This investigation led to the conclusion that our various extracts of the fruit peel of Punica granatum have a significant capacity to fight inflammation by preventing lysis of the lysosomal membrane. This capacity varies depending on the extraction solvent and the concentration of extract used. [ABSTRACT FROM AUTHOR]

The NTFPs refer to any biological resource except that obtained from timber from woods or any other forested ecosystem. Thus, the NTFPs are ecologically forest-based, whether they come from the spontaneous flora or crops (home gardens, agroforestry, rural orchards) or from wild animals (Tabuna, 1999). They include vegetables, mushrooms, fruit and their extracts, essential oils, edible insects, honey, medicinal plants, game animals etc. Extractivism refers to collecting NTFPs for commercial purposes (Nguenang et Feteke, 2000). [ABSTRACT FROM AUTHOR]