1. [3D cellular models: a powerful access to cutaneous physiology and to innovative developments of cosmetic active compounds].
- Author
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André V, Grenier S, Pivard F, and Perrier E
- Subjects
- Adult, Age Factors, Aged, Cell Adhesion, Chitosan, Chondroitin Sulfates, Collagen Type I, Collagen Type III, Cosmetics pharmacology, Culture Media, Drug Evaluation, Preclinical, Enzyme-Linked Immunosorbent Assay, Fibroblasts drug effects, Fibroblasts metabolism, Fibronectins biosynthesis, Gelatin Sponge, Absorbable, Humans, Laminin biosynthesis, Middle Aged, Skin ultrastructure, Skin Physiological Phenomena, Tissue Engineering instrumentation, Animal Testing Alternatives, Fibroblasts cytology, Skin, Artificial, Tissue Culture Techniques instrumentation, Tissue Engineering methods
- Abstract
Two different anti-ageing cosmetic actives based respectively, on dermal compartment regeneration and on dermoepidermal reinforcement, have been developed using tissular engineering models. Conjointly use of different innovative three-dimensional models such as reconstructed dermis and skin built with human cells coming from variable aged donors allowed first, a better understanding of matrix modifications due to ageing and second, the screening of active ingredients highly targeted to reverse observed damages. The validity of such three-dimensional models has been then confirmed by in vivo studies on healthy volunteers.
- Published
- 2005
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