1. [Pharmacokinetics and pharmacodynamics of vecuronium in children]
- Author
-
K, Steinbereithner, S, Fitzal, S, Schwarz, H, Gilly, M, Semsroth, and M, Weindlmayr-Goettel
- Subjects
Male ,Vecuronium Bromide ,Electromyography ,Age Factors ,Myography ,Neuromuscular Junction ,Infant ,Synaptic Transmission ,Kinetics ,Microcomputers ,Child, Preschool ,Humans ,Female ,Pancuronium ,Neuromuscular Blocking Agents ,Child ,Muscle Contraction ,Neuromuscular Nondepolarizing Agents - Abstract
Pharmacodynamics of vecuronium have been studied in children 1 to 10 years old. Doses from 0.015 to 0.1 mg/kg were given and the effects measured mechanically and by electromyography. For 0.1 mg/kg the pharmacokinetics were established. A smaller distribution volume and higher plasma clearance in children as compared to adults have been found, while the dose-effect ratio is the same. The action of vecuronium is shorter in children than in adults.
- Published
- 1984