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2 results on '"Intraocular lymphoma"'

1. [Multimodal imaging in primary intraocular lymphoma]

Author

S, Santos, M L, Le Lez, S, Arsène, and P J, Pisella

Subjects
Aged, 80 and over, Male, Fundus Oculi, Middle Aged, Prognosis, Multimodal Imaging, Early Diagnosis, Intraocular Lymphoma, Humans, Female, Fluorescein Angiography, Tomography, Optical Coherence, Aged, Retrospective Studies
Abstract

Vitreoretinal lymphoma is a serious disease with highly varied clinical presentations. The goal of this work is to identify the various presentations (clinical, imaging) in order to improve screening for this disease.We collected data of patients followed on our service for vitreoretinal lymphoma. The fundus exam, autofluorescence and angiography data were classified in order to identify signs, which might lead to earlier diagnosis of lymphoma.The diagnosis of vitreoretinal lymphoma was confirmed by vitrectomy or cerebral biopsy for 12 patients (8 women and 4 men). Three clinical presentations were identified: no retinal involvement (2 patients), retinal infiltrate (4 patients) or acute retinal necrosis (3 patients). One patient had no imaging (deceased before it could be obtained), and two patients had uninterpretable imaging.Vitreoretinal lymphoma remains a rare and under-diagnosed disease. The prognosis is related to early diagnosis. Multimodal imaging can help to diagnose early vitreoretinal lymphoma in some cases.

Published
2016

2. [Intraocular lymphoma associated with primary malignant lymphoma of the central nervous system: Seven-year experience of a tertiary center].

Author

Joubert R, Bonnin N, Kemeny JL, Moluçon-Chabrot C, Tournilhac O, Bacin F, and Chiambaretta F

Subjects
Aged, Aged, 80 and over, Brain Neoplasms mortality, Brain Neoplasms pathology, Combined Modality Therapy, Eye Neoplasms mortality, Eye Neoplasms pathology, Female, Humans, Lymphoma, Large B-Cell, Diffuse mortality, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, T-Cell mortality, Lymphoma, T-Cell pathology, Male, Middle Aged, Neoplasms, Multiple Primary mortality, Neoplasms, Multiple Primary pathology, Survival Rate, Brain Neoplasms diagnosis, Brain Neoplasms therapy, Eye Neoplasms diagnosis, Eye Neoplasms therapy, Lymphoma, Large B-Cell, Diffuse diagnosis, Lymphoma, Large B-Cell, Diffuse therapy, Lymphoma, T-Cell diagnosis, Lymphoma, T-Cell therapy, Neoplasms, Multiple Primary diagnosis, Neoplasms, Multiple Primary therapy, Tertiary Care Centers
Abstract

Introduction: Primary intraocular lymphoma (PIOL), associated with primary central nervous system lymphoma (PCNSL), is a rare malignancy disease. By way of a seven-year experience of a tertiary center, we discuss the presentation and we review the diagnostic and therapeutic modalities., Observations: We report six cases of PIOL associated with PCNSL. For all patients, the clinical presentation was a vitreoretinal syndrome. The diagnosis was histologically confirmed by vitreal sample or brain biopsy. Five patients developed a diffuse large B-cell lymphoma. Only one patient developed a T-cell lymphoma. The treatment consisted of conformational radiation therapy, systemic chemotherapy and intravitreal injections of methotrexate. The median survival after the diagnosis was 24 months., Discussion: PIOL, associated with PCNSL, is the most common type of ocular lymphoma. In most cases, ocular manifestations inaugurate the disease. PIOL is often fatal because of ultimate central nervous system presentation. The role of the ophthalmologist consists in early diagnosis. Typical clinical findings include vitroretinal tumor syndrome but can mascarade other eye pathologies. Diagnosis requires histology. The majority of PIOL is diffused large B-cell lymphoma. Decisions are made through multidisciplinary consultation. PIOL exhibits high responsiveness to methotrexate., Conclusion: Through a literature review and many illustrations, we discuss epidemiological, clinical, histological, radiological and treatment characteristics of PIOL associated with PCNSL., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

Published
2015
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