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4. Estimation de l'âge civil de garçons âgés de 12,5 à 16 ans Prediction of teenager's age from 12,5 to 16 years old

Author

pineau, jean-claude, Ludes, Bertrand, Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité (BABEL - FRE 2029), and Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

8. Caractérisation de l’altération osseuse post-mortem par histomorphologie dans un contexte médico-légal : étude taphonomique sur restes humains

Author

Delannoy, Yann, Cannet, Catherine, Louria, Claire, Penel, Guillaume, Colard, Thomas, and Ludes, Bertrand

Subjects
FOS: Biological sciences
Abstract

L’altération d’un os en période post-mortem, est à l’origine d’une détérioration identifiable en histologie. La dégradation de l’os se caractérise notamment par une altération collagénique observable précocement. Dans le but de pouvoir caractériser cette altération, deux côtes ont été prélevées sur 6 corps humains et étudiées prospectivement pendant les 2 ans suivant le décès. Chaque os a fait l’objet d’une coupe histologique étudiée après coloration au rouge Sirius afin de mettre en évidence la dégradation du collagène en fonction du temps. Une altération osseuse temporelle a pu être mise en évidence par une dégradation architecturale de l’os lamellaire, en l’absence de toute attaque microbienne sur cette période post-mortem. La coloration pratiquée à l’aide du rouge Sirius a permis d’attribuer cette altération à une dégradation collagénique de type hydrolyse chimique en raison de l’affinité de ce colorant pour les acides aminés Lysine, Hydroxylysine et Arginine. Notre travail a permis d’affirmer que des échantillons osseux humains étudiés en environnement contrôlé, et analysés pendant 24 mois, subissent une trajectoire diagénétique dont l’élément principal est l’hydrolyse collagénique., The diagenesis of a bone in the post-mortem period causes an identifiable deterioration in histology. More particularly, the degradation of the bone is characterized by a collagenous alteration which is observable very early. In order to be able to characterize this alteration, two ribs collected from 6 human bodies were studied prospectively during 2 years. Each bone was studied after staining with red Sirius in order to demonstrate the degradation of collagen as a function of time. A temporal bone alteration could be demonstrated by an architectural degradation of the lamellar bone in the absence of any microbial attack on this post-mortem period. The coloring carried out using red Sirius correlated this alteration to a collagenic degradation by chemical hydrolysis because the affinity of this colorant to the amino acids Lysine, Hydroxylysine and Arginine. Our work asserts that human bone samples studied in controlled environment, and analyzed for 24 months, undergo a diagenetic trajectory whose main element is collagen hydrolysis.

Published
2017
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9. Amélioration continue du DES de biologie médicale à l’aide d’un carnet de stage et d’un questionnaire d’évaluation de la satisfaction. [= Clinical laboratory medicine: continuous amelioration with a book of objectives and satisfaction survey]

Author

Reix, Nathalie, Agin, Arnaud, Bahram, Seiamak, Dali-Youcef, Nassim, Grucker, Daniel, Jaulhac, Benoit, Lepiller, Quentin, Lessinger, Jean-Marc, Mauvieux, Laurent, Monier, Laurie, Schramm, Frederic, Stoll-Keller, Françoise, Vallat, Laurent, Ludes, Bertrand, Candolfi, Ermanno, Filisetti, Denis, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Bioimagerie et Pathologies (LBP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Dynamique des interactions Hôte pathogène, Université de Strasbourg (UNISTRA), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)

Subjects
book of objectives, objectives, satisfaction survey, improvement, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medical biology training
Abstract

We report in this publication the use of two educational tools, a questionnaire of satisfaction and a training book, to improve the training of students during their internship in clinical laboratory at the "Pôle de biologie des Hôpitaux universitaires de Strasbourg" in France. First, the ongoing training was assessed by the interns with a questionnaire measuring satisfaction. The analysis of this questionnaire identified four key points to improve: 1) define the teaching objectives, 2) organize the training with a schedule, 3) revise certain teaching methods and 4) ensure better integration of the students in the team of medical biologists. After this assessment, we implemented a training book to answer these four points. Indeed, the training book presents the objectives, the schedule of training, and how to validate the educational objectives. A new assessment was performed again using the same methodology. Results showed an improvement in student satisfaction from 74 to 88 %. The questionnaire of satisfaction and the training book are presented in this article. The aim of the assessment of training combined with the training book is to incite the actors of the training (students and teachers) to continually improve the training. The objectives of the Pôle de Biologie are to obtain an 80 % satisfaction rate during the 6 months trainings and to reduce or eliminate dissatisfaction, and finally to ensure the validation by students of 80 to 100 % of their predetermined objectives.

Published
2015

10. Les auteurs

Author

Savall, Frédéric, Hérin, Fabrice, Alunni, Véronique, Bartoli, Christophe, Bascou, Agathe, Bouvet, Renaud, Dufayet, Laurène, Epain, Marie, Fanton, Laurent, Farrugia, Audrey, Francioni, Sophie, Grill, Stéphane, Jousset, Nathalie, Lefevre, Thomas, Ludes, Bertrand, Manaouil, Cécile, Moutel, Grégoire, Nahmani, Isabelle, Nohales, Ludivine, Peyron, Pierre Antoine, Rouge-Maillart, Clotilde, Scolan, Virginie, Tournel, Gilles, Tuchtan, Lucile, Andujar, Pascal, Baldi, Isabelle, Bensefa-Colas, Lynda, Esquirol, Yolande, Fontana, Luc, Gehanno, Jean-François, Gernigon, Caroline, Gislard, Antoine, Hulo, Sébastien, Lehucher-Michel, Marie-Pascale, Lesage, François-Xavier, Maître, Anne, Pairon, Jean-Claude, Rollin, Laëtitia, Sari-Minodier, Irène, Soulat, Jean-Marc, Thaon, Isabelle, and Villa, Antoine

Published
2022
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11. Utilisation des modèles éléments finis de la tête, du cou et de l’œil de l’enfant en médecine légale

Author

Raul, Jean-Sébastien, Roth, Sébastien, Deck, Caroline, Meyer, Frank, Willinger, Rémy, Ludes, Bertrand, Laboratoire de pharmacologie et de toxicologie neurocardiovasculaire (LPTNC), Université de Strasbourg (UNISTRA), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.MECA]Physics [physics]/Mechanics [physics]
Published
2008

12. Intérêt des modèles éléments finis de la tête dans l’évaluation des mécanismes de lésions en médecine légale, Congrès international de langue française de médecine légale et de médecine sociale

Author

Raul, Jean-Sébastien, Deck, Caroline, Meyer, Frank, Baumgartner, Daniel, Willinger, Remy, Ludes, Bertrand, Laboratoire de pharmacologie et de toxicologie neurocardiovasculaire (LPTNC), Université de Strasbourg (UNISTRA), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.MECA]Physics [physics]/Mechanics [physics]
Published
2004

14. Évaluation préliminaire de la motivation d'étudiants en cours d'externat à remplir les formulaires d'évaluation en ligne des stages hospitaliers.

Author

FARRUGIA, Audrey, PELACCIA, Thierry, POTTECHER, Thierry, and LUDES, Bertrand

Subjects
CLINICAL clerkship, CLINICAL medical education, STUDENT participation, MEDICAL students, MOTIVATION research
Abstract

Copyright of Pédagogie Médicale is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2012
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15. La cavalière de Hochfelden

Author

Alduc-Le Bagousse, Armelle, Blondiaux, Joël, Pilet, Christian, Centre Michel de Boüard - Centre de recherches archéologiques et historiques médiévales (CRAHM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Schnitzler Bernadette, Le Minor Jean-Marie, Ludes Bertrand, Boës Eric (dir.), Centre Michel de Boüard - Centre de recherches archéologiques et historiques médiévales ( CRAHM ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Centre National de la Recherche Scientifique ( CNRS ), Schnitzler B., Le Minor J.M., Ludes B., Boës E. (dir.), Leroy-Hale, Marie-Noëlle, and Schnitzler Bernadette, Le Minor Jean-Marie, Ludes Bertrand, Boës Eric (dir.)

Subjects
[ SHS.HIST ] Humanities and Social Sciences/History, [SHS.HIST] Humanities and Social Sciences/History, [SHS.HIST]Humanities and Social Sciences/History
Published
2005

17. Les empreintes génétiques en médecine légale

Author

LUDES Bertrand, MANGIN Patrice, LUDES Bertrand, and MANGIN Patrice

Abstract

Dans cet ouvrage, les auteurs présentent la technique utilisée pour obtenir les empreintes génétiques, puis illustrent et commentent l'analyse comparative de ces données par de nombreux exemples. Les notions de génétique moléculaire et les implications médicolégales indispensables à la compréhension et à l'exploitation de cette technique sont également développées. Cet ouvrage d'actualité sans équivalent répond aux besoins des secteurs de plus en plus nombreux qui sont confrontés à ce type d'investigation.

Published
1992

18. Epidemiology of osteoarthritis and enthesopathies in a European population dating back 7 700 years.

Author

Crubézy, Éric, Goulet, Jérome, Bruzek, Jaruslav, Jelinek, Jan, Rougé, Daniel, and Ludes, Bertrand

Subjects
*OSTEOARTHRITIS, *ARTHRITIS, *BONE diseases, *PHYSIOLOGY
Abstract

Objectives. To investigate the epidemiology of bone changes related to degenerative joint disease and enthesopathies in the earliest Neolithic population identified in Europe (dated back 7 700 years), to compare the findings with those in medieval and contemporary populations, and to draw etiological inferences. Methods. Examination of the skeletal remains of 119 individuals older than 20 years of age at death and buried in two Central European cemeteries dated as far back as 7 700 years (5 700 BC). Results. The propensity for developing degenerative disease seemed to vary among individuals, as it does today. The hands, shoulder, and hip were common targets of osteoarthritis, as they are today, and the elbow was more likely to be affected in the Neolithic and medieval populations than in contemporary populations. When age of the individuals is taken into account, the prevalence of knee osteoarthritis does not seem to have changed substantially over time. Conclusions. These results attest to the major role of microtrauma in osteoarthritis of the upper limb joints. At the other joints, after correction for age, the prevalence of degenerative disease and the combinations of joint involvements have remained remarkably constant over time, suggesting a major role for genetic factors (bone formers) already present in European populations in the early Neolithic period. [Copyright &y& Elsevier]

Published
2002

19. Insectes nécrophages

Author

Charabidze, Damien, Centre d'histoire judiciaire (CHJ), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Delabarde, Tania, and Ludes, Bertrand

Subjects
[SDV]Life Sciences [q-bio]
Abstract

National audience

Published
2014

20. [DNA Ancestry and phenotype markers analyses and French law].

Author

Ludes B

Subjects
DNA, Ancient isolation & purification, Ethics, Medical, Female, France, Genetic Testing legislation & jurisprudence, History, Ancient, Humans, Legislation as Topic, Male, Phenotype, Phylogeny, Polymorphism, Single Nucleotide, DNA, Ancient analysis, Forensic Anthropology legislation & jurisprudence, Forensic Anthropology methods, Genetic Markers, Pedigree
Abstract

Since some of the genetic markers involved in the analyses are single nucleotide polymorphisms located in protein-coding regions or exons, their analyses are today forbidden for forensic application in French law. A recent application of the French Criminal Chamber of "Cour de Cassation" indicates that it would be possible to perform phenotypic studies and Ancestry Informative Markers (AIM) analysis on stain samples but not on samples taken from a body. The authors present the results of the HIrisplex test performed on seven bone samples belonging to a Mongolian Altaï population dated from the late Bronze Age. On account of the obtained results, the authors raise the question of the use of HIrisplex test on corpses and on skeletonized human remains for their identification.

Published
2016

21. [Clinical laboratory medicine: continuous amelioration with a book of objectives and satisfaction survey].

Author

Reix N, Agin A, Bahram S, Dali-Youcef N, Grucker D, Jaulhac B, Lepiller Q, Lessinger JM, Mauvieux L, Monier L, Schramm F, Stoll-Keller F, Vallat L, Ludes B, Candolfi E, and Filisetti D

Subjects
Education methods, Goals, Job Satisfaction, Quality Improvement, Records, Surveys and Questionnaires, Education standards, Medical Laboratory Science education
Abstract

We report in this publication the use of two educational tools, a questionnaire of satisfaction and a training book, to improve the training of students during their internship in clinical laboratory at the "Pôle de biologie des Hôpitaux universitaires de Strasbourg" in France. First, the ongoing training was assessed by the interns with a questionnaire measuring satisfaction. The analysis of this questionnaire identified four key points to improve: 1) define the teaching objectives, 2) organize the training with a schedule, 3) revise certain teaching methods and 4) ensure better integration of the students in the team of medical biologists. After this assessment, we implemented a training book to answer these four points. Indeed, the training book presents the objectives, the schedule of training, and how to validate the educational objectives. A new assessment was performed again using the same methodology. Results showed an improvement in student satisfaction from 74 to 88 %. The questionnaire of satisfaction and the training book are presented in this article. The aim of the assessment of training combined with the training book is to incite the actors of the training (students and teachers) to continually improve the training. The objectives of the Pôle de Biologie are to obtain an 80 % satisfaction rate during the 6 months trainings and to reduce or eliminate dissatisfaction, and finally to ensure the validation by students of 80 to 100 % of their predetermined objectives.

Published
2015
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22. [DNA analysis in the anthropological approach of ancient populations].

Author

Keyser C, Crubézy E, and Ludes B

Subjects
Humans, Siberia, Anthropology, DNA analysis, Ethnicity genetics
Abstract

The authors highlight the opportunities to reconstruct the human Eurasian steppe migration movements with the analyses of nuclear DNA markers (short tandem repeats on autosomal DNA and on the Y chromosome) as well as mitochondrial DNA markers. They studied 26 ancient human samples from the Krasnoyarsk area (Southern Siberia). The specimens were dated from the middle of the second millennium BC to the fourth century AD. The Y chromosome and the mitochondrial analyses revealed that few of them seem to be related matrilineally or patrilineally, but all subjects belong to Y haplogroup R1a1a-M17 which is known as a marker of the eastward migration of the early Indo-Europeans. Their results are in accordance with the hypothesis that at the Bronze and Iron Ages south Siberia was settled predominantly by European subjects suggesting an eastward migration of kurgan people across the Russo-Kazakh steppe. The single nucleotide polymorphisms (SNP) analyses on the physical traits indicate that the ancient studied specimens were blue or green eyed, fair skinned and light-haired., (© 2013 médecine/sciences – Inserm.)

Published
2013
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24. [Study of Siberian population movements: use of multiple markers].

Author

Ludes B

Subjects
Chromosomes, Human, Y genetics, Culture, Ethnicity genetics, Ethnicity history, Europe ethnology, Eye Color genetics, Female, Hair Color genetics, Haplotypes genetics, History, Ancient, Humans, Male, Polymorphism, Single Nucleotide genetics, Siberia, Skin Pigmentation genetics, White People genetics, Chromosomes, Human genetics, DNA, Mitochondrial genetics, Genetic Markers, Human Migration history, Mummies, White People history
Abstract

To further explore early Eurasian steppe migration, we determined the Y chromosome and mitochondrial haplotypes of 26 ancient human specimens from the Krasnoyarsk area, dated between the middle of the second millennium BC and the fourth century AD. Our autosomal Y chromosome and mitochondrial DNA analyses reveal that, whereas few specimens seem to be related matrilineally or patrilineally, nearly all the subjects belong to haplogroup R1a1--M17, which is thought to mark the eastward migration of early Indo-Europeans. Our results also confirm that, during the Bronze and Iron Ages, southern Siberia was a region of overwhelming European settlement.

Published
2012

26. [Y-chromosome analysis].

Author

Keyser-Tracqui C and Ludes B

Subjects
DNA genetics, DNA Fingerprinting legislation & jurisprudence, Evolution, Molecular, Forensic Anthropology methods, Genetic Markers, Haplotypes genetics, Humans, Male, Microsatellite Repeats, Paternity, Chromosomes, Human, Y genetics
Abstract

After initially slow progress in identifying DNA polymorphisms on the non recombining part of the human Y chromosome, a large number of polymorphic markers are now available to define individual or population-specific haplotypes or haplogroups. Among them the Y-chromosomal STRs (Short Tandem Repeats) have been increasingly used over the past few years for the study of human evolution as well as for human identification in forensic case-work and paternity testing. After a brief summary of the features of such markers, this paper deals with some applications of the Y-STR haplotyping.

Published
2003

27. [Child abuse].

Author

Ludes B

Subjects
Child, Child Abuse therapy, Child Development, Diagnosis, Differential, Humans, Physician's Role, Violence, Child Abuse diagnosis, Child Welfare
Abstract

Child abuse occurs frequently and necessitates a multidisciplinary approach--medical, surgical, psychopathological, social and legal, as much for its prevention as for its diagnosis and treatment. It comprises all forms of psychological and physical violence as well as neglect, which lead to an impact on the general state of the child, gravely harming its physical and psychological development. The diagnosis of child abuse is difficult to make, as there exist no pathognomic criteria of maltreatment, and denial is usual in the perpetrators when they are identified.

Published
2002

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