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5 results on '"MESH: Cytomegalovirus Infections"'

1. Étude des facteurs prédictifs de séquelles à 2 ans en lien avec une infection congénitale à Cytomégalovirus

Author

Petermann, Lucile, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), and Jean-François Magny

Subjects
MESH: Cytomegalovirus, MESH: Immunologic Deficiency Syndromes, Dépistage sérologique systématique, MESH: Maternal Serum Screening Tests, Handicap, Symptomatic, Trouble neuro-développemental, MESH: Prognosis, Hearing impairment, Congenital infection, Infection congénitale, MESH: Risk Factors, Pronostic, MESH: Therapeutics, Traitement, MESH: Hearing Loss, MESH: Neurodevelopmental Disorders, Facteurs de risques, MESH: Cytomegalovirus Infections, MESH: Disabled Persons, Cytomégalovirus, Déficience, Déficience auditive, Impairment, Symptomatique, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Objectives: cytomegalovirus (CMV) is the leading cause of congenital infection in the world with a major risk of sequelae including neurological and auditory. The aim of the study is to identify what are the prognostic factors for defining neonates at risk of developing sequelae at 2 years related to congenital CMV infection. Design of the study: monocentric retrospective observational study including 220 patients born between January 2001 and October 2015 with congenital CMV infection. We studied various pre- and postnatal factors and their impact on the outcome at 2 years of age for children with congenital CMV infection. Results: the presence of at least one postnatal abnormality (clinical examination or additional investigations) was a risk factor for developing sequelae at 2 years (p = 0.037). Neonates with maternal seroconversion in the first trimester were more likely to develop sequelae at 2 years (p

Published
2018

2. Infections et grossesse : un danger pour la mère et l'enfant

Author

Charlier, Caroline, Lecuit, Marc, Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies infectieuses et tropicales [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Institut Pasteur [Paris]-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Biologie des Infections - Biology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP]-Institut des Maladies Génétiques Imagine [Paris], and Centre collaborateur de l'OMS Listeria - Biologie des Infections (CCOMS)

Subjects
MESH: Humans, [SDV]Life Sciences [q-bio], MESH: Rubella, MESH: Rubella Syndrome, Congenital, MESH: Vaccination, MESH: Cytomegalovirus Infections, MESH: HIV Infections, MESH: Streptococcus agalactiae, MESH: Male, MESH: HIV-1, MESH: Infectious Disease Transmission, Vertical, MESH: Pregnancy, MESH: Streptococcal Infections, MESH: Listeriosis, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Chickenpox, MESH: Pregnancy Complications, Infectious, MESH: Contraindications, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Chaque année, on dénombre plus de 800 000 grossesses en France. Il n'est pas rare au cours de cette période qu'une femme enceinte soit confrontée à un événement évoquant une infection : fièvre, contage infectieux, découverte d'anomalies sérologiques lors de dépistages systématiques, prescription de traitements antibiotiques, administration d'un vaccin sont autant de situations fréquentes, dont le clinicien doit avoir la maîtrise chez la femme enceinte. Des enjeux multiples Les enjeux d'une infection maternelle sont multiples et souvent chevauchants. Le premier est maternel, car certaines infections sont démontrées plus sévères chez la femme enceinte.

Published
2014
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3. [Cytomegalovirus and cryptogenic inflammatory bowel disease]

Author

Pofelski, Joanna, Heluwaert, Frédéric, Roblin, Xavier, Morand, Patrice, Gratacap, Bénédicte, Germain, Emmanuel, Brion, Jean-Paul, Salon, Caroline, Bonaz, Bruno, Sinniger, Valérie, Service d'hépato-gastroentérologie, CHU Grenoble, Laboratoire de virologie moléculaire et structurale, Département de médecine aiguë spécialisée, CHU Grenoble-Hôpital Michallon, and Département d'anatomo-pathologie

Subjects
MESH: Antiviral Agents, MESH: Cytomegalovirus, MESH: Humans, MESH: Immunologic Factors, MESH: Virus Replication, Cytomegalovirus, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, MESH: Cytomegalovirus Infections, MESH: Inflammatory Bowel Diseases, Inflammatory Bowel Diseases, Virus Replication, digestive system, Antiviral Agents, digestive system diseases, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Cytomegalovirus Infections, Humans, Immunologic Factors
Abstract

International audience; CMV infection has been reported in association with some flares of IBD. Its prevalence varies with the method of diagnosis and the severity of IBD. Although the link between CMV and IBD is not clear, the immunomodulator properties of the virus may play a role in the evolution of IBD. Besides the necessity of immunosuppression to treat IBD, inflammation per se can maintain in situ viral replication. Antiviral treatment can be useful in some situations. New molecular methods will permit earlier and more sensitive diagnosis of CMV infection and a better evaluation of treatment efficacy.

Published
2007

4. [Management of severe or corticosteroid resistant ulcerative colitis]

Author

Carbonnel, Franck, Humbert, Murielle, Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
MESH: Antiviral Agents, Time Factors, Anti-Inflammatory Agents, Drug Resistance, MESH: Colitis, Ulcerative, Antiviral Agents, MESH: Cyclosporine, MESH: Antibodies, Monoclonal, Gastrointestinal Agents, Humans, Multicenter Studies as Topic, Prospective Studies, Radionuclide Imaging, Ganciclovir, Colectomy, ComputingMilieux_MISCELLANEOUS, Randomized Controlled Trials as Topic, MESH: Colectomy, MESH: Humans, MESH: Time Factors, Antibodies, Monoclonal, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, MESH: Cytomegalovirus Infections, MESH: Gastrointestinal Agents, Infliximab, MESH: Prospective Studies, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, MESH: Randomized Controlled Trials as Topic, MESH: Anti-Inflammatory Agents, Cytomegalovirus Infections, MESH: Ganciclovir, Cyclosporine, MESH: Multicenter Studies as Topic, MESH: Drug Resistance, Colitis, Ulcerative, MESH: Immunosuppressive Agents, Immunosuppressive Agents, Foscarnet, MESH: Foscarnet
Abstract

National audience

Published
2007

5. Hypomorphic RAG1 mutations and CMV infection: a new phenotype of severe combined immunodeficiency

Author

Le Deist, Françoise, De Villartay, Jean-Pierre, Lim, Annick, Déchanet-Merville, Julie, Fischer, Alain, Developpement Normal et Pathologique du Système Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Référence Déficits Immunitaires Héréditaires (CEREDIH), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunité Antivirale, Biothérapie et Vaccins, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Composantes innées de la réponse immunitaire et différenciation (CIRID), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Référence Déficits Immunitaires Héréditaires ( CEREDIH ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Composantes innées de la réponse immunitaire et différenciation ( CIRID ), and Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique ( CNRS )

Subjects
MESH: Humans, MESH: Mutation, MESH : Humans, MESH : Severe Combined Immunodeficiency, MESH : Nuclear Proteins, MESH: Severe Combined Immunodeficiency, MESH: Cytomegalovirus Infections, MESH: Phenotype, MESH : Cytomegalovirus Infections, MESH : Phenotype, MESH: Homeodomain Proteins, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH : DNA-Binding Proteins, MESH : Homeodomain Proteins, MESH : Mutation, MESH: Nuclear Proteins, MESH: DNA-Binding Proteins
Published
2006
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