1. [The concept of supersensitivity psychosis. The particular case of clozapine]
- Author
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Llorca, Pierre-Michel, Penault, F., Lançon, C., Dufumier, E., Vaiva, G., CHU Clermont-Ferrand, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), and Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,MESH: Dissociative Disorders ,MESH: Psychoses, Substance-Induced ,MESH: Humans ,MESH: Drug Tolerance ,MESH: Substance Withdrawal Syndrome ,Catatonia ,MESH: Adult ,Dissociative Disorders ,Drug Tolerance ,Psychoses, Substance-Induced ,MESH: Male ,Substance Withdrawal Syndrome ,MESH: Recurrence ,Recurrence ,MESH: Catatonia ,MESH: Psychomotor Disorders ,Humans ,MESH: Antipsychotic Agents ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Psychomotor Disorders ,MESH: Clozapine ,Clozapine ,Antipsychotic Agents - Abstract
International audience; Neuroleptics are the main biological treatment for psychotic patients. The brutal withdrawal of a neuroleptic treatment may induce an important aggravation of the psychotic symptoms. A few of those relapses may occur very early after the interruption of treatment; they are often associated with a modification of the symptoms and an unfavorable evolution in the course of the illness. Using those clinical observations a few authors have developed the concept of supersensitivity psychosis to explain those kinds of relapses and to formulate hypothesis about tolerance and resistance to neuroleptics. They focus on the possible correlation between supersensitivity psychosis and tardive dyskinesia. We report three cases of a dramatic aggravation of the psychotic symptomatology following the withdrawal of clozapine in three schizophrenic patients resistant to classical neuroleptic treatment. According to the clinical data and to the physiopathological hypothesis, the concept of supersensitivity psychosis can have implications in the therapeutic management of resistant schizophrenic patients.
- Published
- 1999