1. [Erythrocyte superoxide dismutase (eSOD) determination in positive moments of psychosis]
- Author
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Vaiva G, Thomas P, Jm, Leroux, Cottencin O, Dutoit D, Erb F, Goudemand M, Laboratoire de Neurosciences Fonctionnelles et Pathologies ( LNFP ), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ), HEC Montréal ( HEC Montréal ), CIRPEE, Centre Interuniversitaire sur le Risque, les Politiques Economiques et l'Emploi, Canada Research Chair in Drug Delivery, University of Montreal, Centre de recherche inter-langues sur la signification en contexte ( CRISCO ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), HEC Montréal (HEC Montréal), Centre interuniversitaire sur le risque, les politiques économiques et l'emploi [Montréal] (CIRPEE), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Service de Psychiatrie [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Michel Fontan 1, and Wartel, Anny
- Subjects
Adult ,Male ,Erythrocytes ,MESH : Male ,MESH: Psychotic Disorders ,MESH : Schizophrenia ,mental disorders ,MESH : Psychotic Disorders ,Humans ,MESH : Female ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH : Superoxide Dismutase ,MESH: Superoxide Dismutase ,MESH: Humans ,Superoxide Dismutase ,MESH: Erythrocytes ,MESH : Humans ,MESH: Adult ,MESH : Adult ,MESH: Male ,MESH: Schizophrenia ,Psychotic Disorders ,MESH : Antipsychotic Agents ,[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Schizophrenia ,MESH: Antipsychotic Agents ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH: Female ,Antipsychotic Agents ,MESH : Erythrocytes - Abstract
International audience; Dysregulation of free radical metabolism has been supposed to be involved in schizophrenia etiopathogeny. Recently, Wang et al. showed a red blood cell super oxide dismutase increase in positive schizophrenia (Crow's type I), but neither in negative schizophrenia (Crow's type II) nor in controls. The study included 28 in-patients suffering from acute positive psychosis who were compared with 15 controls. We confirmed the results of Wang. We found a significantly red blood cell Super oxide dismutase increase in positive psychosis, in comparison to negative psychosis and controls (p = 0.0001). This SOD increase was in relationship with the degree of clinical psychomotor excitement. After 21 days of neuroleptic treatment, SOD activity decreased and reached standard values. These results support the hypothesis of striking relationships between catecholaminergic hyper-metabolism and SOD increase, in positive psychosis. These could account for psychotic positive symptoms improvement with neuroleptic treatment, which blocks dopamine pathways.
- Published
- 1994