1. A biochemical model for neurite outgrowth during brain development
- Author
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Arlette Fellous, Jacques Nunez, Françoise Chantoux, Jacques Francon, Jeanine Osty, A. Mareck, Ana Maria Lennon, and Revues Inra, Import
- Subjects
Embryology ,Aging ,Neurite ,Microtubule-associated protein ,Period (gene) ,Tau protein ,Models, Neurological ,Medicine (miscellaneous) ,Nerve Tissue Proteins ,macromolecular substances ,Microtubules ,03 medical and health sciences ,0302 clinical medicine ,Tubulin ,[SDV.BDD] Life Sciences [q-bio]/Development Biology ,Biological neural network ,Animals ,Peptide sequence ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,[SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,0303 health sciences ,biology ,Brain ,Proteins ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,In vitro ,Axons ,Cell biology ,Rats ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Reproductive Medicine ,Animals, Newborn ,biology.protein ,Animal Science and Zoology ,Microtubule-Associated Proteins ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Developmental Biology ,Food Science - Abstract
Maximal amounts of tubulin in rat brain are observed during the 3 to 10-day postnatal period. The rates of in vitro tubulin polymerization are very low at these stages of development; they increase thereafter during the second postnatal week, reaching a maximum at adulthood. The increased rate of polymerization could depend either on modifications in the concentration and activity of microtubule-associated proteins (MAPs), which play a crucial role in microtubule assembly in vitro, or on changes in their composition. The results show that the composition and activity of TAU proteins (MW: 58-68000) change during development. Analysis of "young" and "adult" TAU protein peptide mapping suggests that their amino acid sequence is different. Our data indicate a good correlation between tubulin capacity to polymerize in vitro and changes in the composition and activity of TAU proteins which occur during the critical period when the neuronal network is constructed.
- Published
- 1982