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The interaction dynamics between the drug flurbiprofen (FBP) and human serum albumin (HSA) has been investigated by time-resolved fluorescence spectroscopy, combining femtosecond fluorescence upconversion and picosecond time-correlated single photon counting. In order to obtain additional information on the drug/ protein interaction, several covalently linked model dyads, composed of FBP and tryptophan or tyrosine, were also studied. For all systems, the main feature was a remarkable dynamic FBP fluorescence quenching, more prominent in the dyads than in the protein complex. All systems also displayed a clear stereoselectivity depending on the (S)- or (R)-form of FBP, that was strongly influenced by the conformational arrangement of the investigated chromophores.

Las ideas incluidas en este artículo se centran en tres aspectos: la génesis de ANELE, la evolución del sector editorial y las relaciones entre ANELE y las administraciones con competencias en educación. Dentro de este último apartado, destacamos las reflexiones en torno a los filtros establecidos para la autorización y aprobación de los libros de texto y defendemos un mayor protagonismo en la toma de decisiones del profesorado y menor intervención de las burocracias administrativas. El artículo recoge también la entrevista realizada a D. Mauricio Santos Arrabal, presidende de ANELE.