1. [Circulating citrulline levels: a biomarker for intestinal functionality assessment]
- Author
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Nathalie Neveux, Mouna Hanachi, Pascal Crenn, Luc Cynober, Groupe de Recherche Clinique et Technologique sur le Handicap ( GRCTH ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ), AP-HP Hôpital Raymond Poincaré [Garches], Prévention et traitement de la perte protéique musculaire en situation de résistance à l'anabolisme ( PRETRRAM - EA 4466 ), Université Paris Descartes - Paris 5 ( UPD5 ), Service de biochimie et de génétique moléculaire [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Crenn, Pascal, Groupe de Recherche Clinique et Technologique sur le Handicap (GRCTH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [AP-HP], Prévention et traitement de la perte protéique musculaire en situation de résistance à l'anabolisme (PRETRRAM - EA 4466), Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Cochin [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Arginine ,030309 nutrition & dietetics ,medicine.medical_treatment ,[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition ,MESH : Models, Biological ,MESH: Intestinal Diseases ,Gastroenterology ,Severity of Illness Index ,MESH : Nutritional Status ,chemistry.chemical_compound ,0302 clinical medicine ,[ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] ,Citrulline ,insuffisance intestinale ,[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,2. Zero hunger ,MESH : Intestines ,0303 health sciences ,Kidney ,General Medicine ,MESH : Intestinal Diseases ,MESH: Nutritional Status ,3. Good health ,Intestines ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Urea cycle ,Biomarker (medicine) ,MESH : Severity of Illness Index ,[ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,MESH: Intestines ,medicine.medical_specialty ,Enterocyte ,Nutritional Status ,Biology ,Models, Biological ,entérocyte ,03 medical and health sciences ,intestin ,Internal medicine ,MESH: Severity of Illness Index ,medicine ,Humans ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,MESH: Clinical Laboratory Techniques ,Chemotherapy ,MESH: Humans ,Clinical Laboratory Techniques ,Citrullinemia ,MESH : Humans ,MESH: Biological Markers ,MESH: Models, Biological ,MESH : Citrulline ,[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,MESH : Clinical Laboratory Techniques ,medicine.disease ,[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology ,MESH : Biological Markers ,Intestinal Diseases ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Endocrinology ,chemistry ,citrulline ,MESH: Citrulline ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Biomarkers - Abstract
International audience; Circulating citrulline is emerging as an innovating biomarker candidate for assessment of intestinal function. Amino acid synthesized by enterocytes of intestinal mucosal, citrulline is not included in proteins or nutrition products and is a precursor for production of arginine by the kidney. Plasma citrulline is, in clinical situation, an established biomarker of enterocyte functional metabolic mass (trophicity) in children and in adult patients due to its high relation to active functional small bowel remnant length in intestinal diseases (short bowel, extensive enteropathies, intestinal toxicity of chemotherapy and radiotherapy. Plasma citrulline concentration (30-50 μmol/L), independent of nutritional status, if less than 10 μmol/L can give an objective threshold for nutrition parenteral use in case of intestinal failure due to enterocyte abnormalities or lack. Its regular dosage allows the monitoring of intestinal function except in case of significant renal failure.
- Published
- 2011
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