1. [Perfusion MR imaging for initial diagnosis and follow-up of brain tumors]
- Author
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Le Bas, Jean-François, Grand, Sylvie, Kremer, Stéphane, Tropres, Irène, Jiang, Z., Krainik, Alexandre, Rémy, Chantal, Berger, François, Benabid, Alim-Louis, Service d'Imagerie par Résonance Magnétique (IRM), CHU Grenoble, Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service de radiologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], RMN biomédicale : de la cellule à l'homme (RBCH), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-DIR CENTRALE DU SSA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Sino-Français, Neuroimagerie Fonctionnelle et Metabolique, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'oncologie médicale, Département de neurochirurgie, Dojat, Michel, and CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)
- Subjects
Male ,Lymphoma ,Biopsy ,Oligodendroglioma ,perfusion imaging ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,MESH: Meningioma ,Astrocytoma ,MESH: Tomography, Emission-Computed, Single-Photon ,MESH: Magnetic Resonance Imaging ,MESH: Glioma ,Diagnosis, Differential ,MESH: Biopsy ,MESH: Brain ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,MESH: Diagnosis, Differential ,Meningeal Neoplasms ,Humans ,MESH: Oligodendroglioma ,oligodendrogliomas ,Neoplasm Staging ,Tomography, Emission-Computed, Single-Photon ,MESH: Middle Aged ,MESH: Humans ,Brain Neoplasms ,Brain ,MESH: Neoplasm Staging ,MESH: Cerebrovascular Circulation ,MESH: Follow-Up Studies ,Glioma ,Middle Aged ,MESH: Meningeal Neoplasms ,Magnetic Resonance Imaging ,MESH: Male ,MESH: Astrocytoma ,Cerebrovascular Circulation ,MESH: Brain Neoplasms ,Female ,MESH: Lymphoma ,Meningioma ,MESH: Female ,brain tumor ,MRI ,Follow-Up Studies - Abstract
National audience; OBJECT: To discuss the pertinency of perfusion MR imaging for initial diagnosis and follow up of brain tumors. METHODOLOGY: Dynamic susceptibility contrast MR imaging was applied. Images were thus obtained with intensities proportional to the cerebral blood volume (CBV). Relative cerebral blood volume (rCBV) maps were then generated by normalizing the signal intensities with respect to measurements made in healthy tissue. RESULTS: The method provided interesting data for establishing the differential diagnosis between different kinds of lesions, in particular between lymphoma and pilocytic astrocytoma, and for grading gliomas. DISCUSSION AND CONCLUSION: Limits of the approach are discussed, in particular with respect to quantification aspects and interpretation of the results. The approach could be particularly useful for grading oligodendrogliomas, for which histological diagnosis on biopsy is sometimes difficult.
- Published
- 2005