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Your search keyword '"Parathion analogs & derivatives"' showing total 2 results
Start Over Descriptor "Parathion analogs & derivatives" Language french
2 results on '"Parathion analogs & derivatives"'

1. [Effect of methyl parathion and zineb administration on the activity of some hepatic enzymes in rats].

Author

Albrecht R, Pélissier MA, Manchon P, and Dupuis D

Subjects
Aminopyrine N-Demethylase metabolism, Aniline Hydroxylase metabolism, Animals, Glucose-6-Phosphatase metabolism, Glucosephosphate Dehydrogenase metabolism, Male, Organ Size, Oxygenases metabolism, Phosphogluconate Dehydrogenase metabolism, Proteins metabolism, Rats, Methyl Parathion pharmacology, Microsomes, Liver enzymology, NADH, NADPH Oxidoreductases metabolism, Parathion analogs & derivatives, Thiocarbamates, Zineb pharmacology
Abstract

Male albinos rats were fed diets containing parathion-methyl or Zineb so that the average daily intake is 1/10 or 1/20 lethal dose 50, for a period of 4 or 8 weeks. The activity of hepatic microsomal enzymes, namely :aminopyrine N-demethylase, BHT oxidase, aniline hydroxylase, Butter Yellow & Amaranth reductases, NADPH-cyt. c reductase, G6P phosphatase, were measured. The activities of G6P & 6PG deshydrogenases were also determined. With the application of the parathion-methyl doses, the only effect showed is the lowering of the microsomal protein concentration.

Published
1975

2. [Metabolism and in vitro binding of several organochlorine and organophosphate pesticides to calf thymus DNA and rat liver microsomal proteins].

Author

Decloître F, Chauveau J, Benoit A, and Martin M

Subjects
Aldrin metabolism, Animals, Binding Sites drug effects, Biotransformation, Cattle, Dieldrin metabolism, Hexachlorocyclohexane metabolism, Male, Methylcholanthrene pharmacology, Microsomes, Liver drug effects, Parathion analogs & derivatives, Parathion metabolism, Phenobarbital pharmacology, Proteins metabolism, Rats, Stimulation, Chemical, DNA metabolism, Insecticides metabolism, Microsomes, Liver metabolism
Abstract

The organophosphorus insecticide ethyl-parathion was transformed by rat liver microsomes into metabolites which were bound to calf thymus DNA, in large amount. When the rats were treated by phenobarbital or 3-methylcholanthrene, the metabolite binding to DNA was increased two-fold. By contrast, in the same conditions, the organochlorine insecticides, aldrin, dieldrin and gamma hexachlorocyclohexane (lindane), did not yield metabolites able to bind to DNA and to proteins.

Published
1975

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