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38 results on '"Sassi C."'

36. Health related quality-of-life in systemic sarcoidosis in Tunisia.

Author

Kefi A, Helali W, Ben Abdelghani K, El Euch M, Sassi C, Turki S, and Abderrahim E

Subjects
Humans, Cross-Sectional Studies, Tunisia epidemiology, Quality of Life, Surveys and Questionnaires, Sarcoidosis diagnosis, Sarcoidosis epidemiology, Sarcoidosis complications, Cholestasis complications
Abstract

Introduction: Sarcoidosis is a systemic granulomatosis that can be associated with large-scale physical and mental disability, affecting the health related quality-of-life (HRQoL) of patients., Aim: To evaluate the HRQoL of tunisian patients with sarcoidosis and to identify the factors that influence it., Methods: We conducted an analytical, cross-sectional study collecting 31 patients with sarcoidosis according to the ATS/ERS/WASOG criteria. The evaluation of the HRQoL was assessed by two questionnaires in tunisian dialect. The generic score was the Medical Outcome Study 36-Short Form Health Survey (SF-36).The specific score used was the Sarcoidosis Health Questionnaire (SHQ)., Results: The HRQoL of our 31 patients was more affected in the three domains of the SHQ compared to the SF-36, which is in favor of the better sensitivity of the SHQ to detect the influence of the extent of sarcoidosis on the HRQoL. Factors associated with more impaired HRQoLwere: age at disease onset, age at interview, comorbidities, altered spirometry results, ocular involvement, chronic cholestasis, splenic nodules, arthralgia, organ count ≥3, lymphopenia and cholestasis at the time of the interview. Taking an immunosuppressant agent, particularly Methotrexate, was associated with HRQoL improvement. The number of relapses was the most correlated factor with an altered HRQoL, and this in several domains., Conclusion: For an effective management of patients with sarcoidosis, a bio-psycho-social approach is now necessary in order to assess the real and global impact of the disease and to improve the HRQoL of patients. Disease-specific scores seem more reliable in achieving these goals.

Published
2023

37. [Continuous blood gas monitoring in intensive care units].

Author

Giomarelli PP, Biagioli B, Sassi C, Rosi R, Spinelli G, and Grossi A

Subjects
Humans, Intensive Care Units, Therapy, Computer-Assisted, Blood Gas Monitoring, Transcutaneous methods
Abstract

The measurement of O2 and CO2 transport in the arterial and venous mixed blood constitutes the intersection between haemodynamic data and expiratory-inspiratory gases. The arterial-venous difference in O2 (a-v-DO2) and the venous arterial difference in CO2 (v-a-DCO2) calculated from the data of PA, PO2, PCO2 (read by an ABL4 Radiometer) revealed a close correlation with a a-v-DO2 measured directly by means of the LEXO2 (r = 0.99) or with VCO2 measured in expired gases by a capnograph (r = 0.99). In heart surgery the "on-line" monitoring of VCO2, a-v-DO2 and related parameters (REE = Resting Energy Expenditure) in the operating room and in ICU by means of a PDMS (Patients Data Management System) provides very useful information which, when integrated with haemodynamic parameters, allows a better understanding and better care of critical patients.

Published
1991

38. [Ultrastructural changes in the saphenous vein removed during aorto-coronary bypass].

Author

Sassi C, Tanganelli P, Sani G, Antonelli R, Paolini G, Stefano PL, Salvi M, Cosimi A, Pula G, and Giomarelli PP

Subjects
Endothelium, Vascular pathology, Graft Occlusion, Vascular prevention & control, Humans, Platelet Aggregation, Saphenous Vein transplantation, Spasm pathology, Specimen Handling, Coronary Artery Bypass methods, Saphenous Vein ultrastructure
Abstract

In order to observe ultrastructural changes of the saphenous vein before implantation during coronary artery by-pass surgery, 58 fragments from a series of 29 consecutive patients, were studied by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Two fragments were taken: the first just before the distal anastomosis; the second just before the last anastomosis on the aorta. The vein graft was kept in a finger solution of 10% nitroglycerin. Forced dilatation was avoided. The EM showed areas of early loss of the endothelial layer, not time-related, deposits of fibrin and blood corpuscular elements with muscular contraction in 75% of the examined grafts. From our experience and according to the literature, loss of the endothelial layer, spasm and early platelet and fibrin aggregation, are constant features of the explanted saphenous vein. In clinical practice, we emphasize, in addition to the "no touch technique", the early use of antiplatelet drugs during coronary artery by-pass coronary surgery.

Published
1989

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