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1. [Suppressor cells in the "in vitro" induced cell mediated immune response: their origin and target (author's transl)].

Author

StC Sinclair NR, Fung FY, and Vichos EE

Subjects
Animals, Binding Sites, Antibody, Cytotoxicity Tests, Immunologic, Immunoglobulin Fc Fragments, Lymphocyte Culture Test, Mixed, Mice, Mice, Inbred CBA, Mice, Inbred DBA, Immunity, Cellular, Immunosuppression Therapy
Abstract

Suppressor cells, produced in a mixed lymphocyte reaction between CBA and irradiated DBA/2 lymphocytes, inhibited the production of cytotoxic CBA cells in a second MLR. There were several suppressor cells: T and non-T cells, cells with or without Fc-receptors, and cytotoxic as well as non-cytotoxic cells. Reconstitution of the in vitro production of cytotoxic as well as non-cytotoxic cells. Reconstitution of the in vitro production of cytotoxic lymphocytes in suppressed cultures by supplementary CBA cells was better than that which took place after the addition of DBA/2 stimulator cells.

Published
1977

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