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The Self-Ironing Machine is an innovative solution designed to revolutionize fabric ironing on a small scale, catering to the increasing demand for portable and user-friendly ironing devices. It integrates intelligent features to enhance versatility, including a compact design housing essential elements such as a heating plate, a heating roller, and a temperature identification sensor, alongside specialized buttons for different fabric types. The project's objective was to develop a portable self-ironing machine that simplifies the ironing process while maintaining effectiveness.The machine utilizes a heating plate for precise heating and a weighted roller for consistent pressure application, ensuring optimal results. A standout feature is the integration of a temperature identification sensor, enabling customized ironing treatments tailored to specific fabric requirements. This streamlines the process and reduces the risk of damage to delicate fabrics. User interaction is intuitive with dedicated buttons catering to various fabric needs.Rigorous testing has demonstrated the machine's outstanding performance across different fabric types, highlighting its accuracy and adaptability. In conclusion, the Portable Self-Ironing Machine represents a significant advancement in fabric ironing technology. Its compact and efficient design, coupled with intelligent features, offers an enhanced user experience. With its ability to deliver precise and tailored ironing treatments, this machine stands as a game-changer in the realm of portable fabric care, addressing the needs of modern lifestyles and paving the way for future innovations in the field.

Modern advancement in science and technology has altered the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid Arthritis (RA) is chronic progressive autoimmune disease in which body’s immune system has role to protect the health by attacking foreign bacteria but the virus mistakenly attacking the joints as a result thickened synovium, pannus formation, & destruction of bone, cartilage occurs. Researchers are still researching but are unable to know the exact reason for the disease. Although, it is believed that genes and environmental factors play an important role in the development of RA. In this review the pathophysiology, predictors and factors involved in pathogenesis of RA have been investigated. The conventional drug therapeutic agents and emerging novel drug delivery system (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes and so on are discussed, as these are the tools which show promising effect in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused and found to have its potential applications in RA diagnosis and therapy. In addition, the therapeutic effectiveness, and challenges for RA by using these novel drug delivery systems have been reviewed along with its future perspectives.