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Your search keyword '"Virilism prevention & control"' showing total 3 results
Start Over Descriptor "Virilism prevention & control" Language french
3 results on '"Virilism prevention & control"'

1. [21 hydroxylase deficiency: new strategies emerging from molecular studies].

Author

Morel Y, Tardy V, Costa JM, Forest MG, and David M

Subjects
Adrenal Hyperplasia, Congenital enzymology, Adrenal Hyperplasia, Congenital genetics, Amino Acid Substitution, Case Management, Chromosomes, Human, Pair 6 genetics, Dexamethasone therapeutic use, Female, Fetal Diseases diagnosis, Fetal Diseases drug therapy, Fetal Diseases enzymology, Fetal Diseases genetics, Genes, Recessive, Genetic Carrier Screening, Genetic Counseling, Humans, Point Mutation, Pregnancy, Prenatal Diagnosis, Virilism etiology, Virilism prevention & control, Adrenal Hyperplasia, Congenital diagnosis, Steroid 21-Hydroxylase genetics
Published
2003

2. [Prenatal treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 9 treated pregnancies].

Author

Nivelon JL, Chouchane M, Forest MG, Morel Y, Huet F, Nivelon-Chevallier A, and François C

Subjects
Amniocentesis, Dexamethasone pharmacology, Female, Fetal Diseases prevention & control, Follow-Up Studies, Genotype, HLA Antigens analysis, Histocompatibility Testing, Humans, Infant, Newborn, Male, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Pregnancy, Pregnancy Outcome, Risk Factors, Sex Determination Analysis, Treatment Outcome, Trophoblasts, Virilism prevention & control, Adrenal Hyperplasia, Congenital complications, Adrenal Hyperplasia, Congenital diagnosis, Adrenal Hyperplasia, Congenital drug therapy, Adrenal Hyperplasia, Congenital epidemiology, Dexamethasone therapeutic use, Fetal Diseases etiology, Prenatal Care methods, Virilism etiology
Abstract

Prenatal treatment based on administration of dexamethasone to the mother during pregnancy was initiated early during nine pregnancies with a high risk of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. The purpose of this treatment was to prevent fetal virilization by reducing production of androgens by the adrenal glands. Prenatal diagnosis was achieved by comparing amniotic fluid cell HLA genotypes and more recently by subjecting trophoblasts to molecular genetic studies. Together with prenatal determination of fetal sex, this allowed to determine that only two female fetuses were affected. Efficacy of continued prenatal treatment in these two cases was good in one case and mediocre in the other. The treatment was well tolerated by the mothers and fetuses.

Published
1993

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