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To investigate the human exhaled particle motion law under the effects of the thermal plume in a ventilated room, a three-dimensional model of a typical double ward was created. The Large Eddy Simulation was utilized to study the effects of thermal plume of different intensities on particle diffusion, and the removal effects of varied ventilation rates on particles during displacement ventilation were simulated. The results show that the thermal plume formed by a human model at varied room temperatures has a consistent distribution law, and particle diffusion distance and velocity are positively linked with plume intensity. Lower ventilation rates are preferable for particle-removal in the reasonable ventilation mod