1. [From sequence variability to structural and functional prediction: modeling of homologous protein families].
- Author
-
Barrat-Charlaix P and Weigt M
- Subjects
- Animals, Binding Sites genetics, Evolution, Molecular, Humans, Multigene Family, Protein Binding genetics, Protein Interaction Domains and Motifs genetics, Structure-Activity Relationship, Computational Biology methods, Genetic Variation, Proteins chemistry, Proteins physiology, Sequence Analysis, Protein methods, Sequence Homology, Amino Acid
- Abstract
Thanks to next-generation sequencing, the number of sequenced genomes grows rapidly, providing in particular ample examples for the sequence variability between homologous proteins. This article discusses data-driven probabilistic sequence models, which are able to extract a multitude of information from sequence data alone, including (i) structural features like residue-residue contacts, which are formed in the folded protein, (ii) protein-protein interaction interfaces and (iii) phenotypic effects of amino-acid substitutions in proteins., (© Société de Biologie, 2018.)
- Published
- 2017
- Full Text
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