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Objective: To explore the potential targets and underlying mechanism of Rubi Fructus in the treatment of type 2 diabetes mellitus. Methods: Potential active components of Rubi Fructus were proposed by literature search and as well followed the Lipinski’s Rule of Five. The therapeutic targets of potential active components and T2DM-related genes were selected through Swiss target prediction and Gene Cards. The network of potential active components and T2DM-related targets were constructed by Cytoscape 3.7.2, and STRING analysis was performed to reveal the interaction among target proteins and to build the network of protein-protein interaction. Both Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis of core targets were performed using David database. Results: Totally, 68 potential active components of Rubi Fructus and 196 T2DM-related targets were found. Among them, 39 key targets were obtained by network analysis, which were primarily enriched on PI3K-Akt, HIF-1, TNF, Toll-like receptor, and Focal adhesion signaling pathways. Conclusion: For the treatment of T2DM, the active compounts of Rubi Fructus can regulate the expression of proinflammatory and oxidative stress mediators and improving insulin resistance through multiple components, targets, and pathways, which offers a scientific support to further Rubi Fructus studies and to the research on T2DM treatment.

For the precision shear of bars, the kind of rotating high-speed precision cutting method has been given. The structure design of rotary precision shearing machine and the structure design of feeding structure are completed. The method of numerical simulation is used to optimize the cutting tool, and then the experiment platform is completed. Rotary impact and the stress concentration effect of the surface of the bar are used in the paper. The experiment is carried out for the Φ8 mm diameter stainless steel bar stock by changing the speed of the cutting tool through the converter and controlling rod feeding efficiency. The experimental results show that the method is feasible to meet the requirement of various material of the small diameter rod in the industry.

This paper presents the intrinsic fluorescence characteristics of vitamin B1 and vitamin B2 with 3D fluorescence Spectrophotometer. Three strong fluorescence areas of vitamin B2 locate at λex/λem=270/525nm, 370/525nm and 450/525nm and one fluorescence areas of vitamin B1 locates at λex/λem=370/460nm were found. The influence of pH of solution are also discussed, and with the PARAFAC algorithm, 9 vitamin B2 and vitamin B1 mixed solutions are successfully decomposed, and the emission profiles, excitation profiles, central wavelengths and the concentration of the two components were retrieved precisely through about 10 iteration times.

Objective: to prepare and evaluate orally disintegrating films of liquorice inclusion complexes. Methods: the active components of Chinese liquorice were extracted by pressurised extraction technique, and the inclusion complexes were prepared by antisolvent method, while the buccal disintegration films of liquorice inclusion complexes were prepared by solvent casting method, and the prepared buccal disintegration films were evaluated. Results: the home-made liquorice inclusion complexes orally disintegrated films formed better films, had good hardness and toughness, the thickness was around 0.1 mm and could disintegrate within 40 s, and the dissolution was rapid, the cumulative release reached 80.1% within 10 min, reaching the immediate release effect. Conclusion: the prepared buccal disintegrating membranes of liquorice inclusion complexes, which are expected to provide new ideas for the development and study of other drugs in the future, deserve further investigation.

Creepage discharges on oil impregnated pressboard is one of the most dangerous transformer insulation fault, which can cause the gas action even transformer housing cracking accident. “White spot” is creepage important phenomena in the process of insulation board along the surface, so it is necessary to study the insulation board along the surface of creepage “white spot” in the process of growth characteristics. This paper set up a insulating paper along the surface of creepage “white spot” in the process of growth characteristics of observation platform. Numerical example was calculated under different aging degree creepage cardboard along the surface of the “white spot” in the process of change, statistics and analysis of the “white spot” length, angle and size variation, which is very practical to the production practice.