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22 results on '"Youinou, Pierre"'

11. Un nouvel auto-antigène dans le syndrome de Gougerot-Sjögren : la protéine SC35

Author

Tobón, Gabriel J, Paleiron, Nicolas, Devauchelle-Pensec, Valérie, Youinou, Pierre, Pers, Jacques-Olivier, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service de Pneumologie (NP - HIA), Hôpital d'Instruction des armées, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire d'Immunologie et Immunothérapie, and Michel, Geneviève

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

12. CD6 : une nouvelle cible thérapeutique dans le syndrome de Gougerot-Sjögren?

Author

Pers, Jacques-Olivier, Le Dantec, Christelle, Alonso, Ruby, Montero, Enrique, Devauchelle-Pensec, Valérie, Youinou, Pierre, Renaudineau, Yves, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Experimental Immunotherapy, La Habana, Cuba, Center for molecular Immunology, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire d'Immunologie et Immunothérapie, and Michel, Geneviève

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

13. Le Toll-like receptor 9 module la différenciation des lymphocytes B dans les glandes salivaires de patients atteints du syndrome de Gougerot-Sjögren

Author

Pers, Jacques-Olivier, Guerrier, Thomas, Le Pottier, Laëtitia, Devauchelle-Pensec, Valérie, Saraux, Alain, Youinou, Pierre, Jamin, Christophe, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire d'Immunologie et Immunothérapie, and Michel, Geneviève

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

14. De nouveaux critères de diagnostic du Syndrome de Gougerot-Sjögren : valeur diagnostique de l'échographie des glandes salivaires et des sous-populations lymphocytaires B

Author

Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Marhadour, Thierry, Cochener, Béatrice, Boisramé-Gastrin, Sylvie, Pers, Jacques-Olivier, Youinou, Pierre, Devauchelle-Pensec, Valérie, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Université de Brest (UBO), Service d'ophtalmologie [Brest], Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHRU Brest - Service d'Odontologie (CHU - BREST - Odontologie), Laboratoire d'Immunologie et Immunothérapie, and Michel, Geneviève

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2011

15. Quel est l'intérêt de la recherche des anticorps anti-nucléolaires dans la sclérodermie systémique ?

Author

Comacle, Pauline, Padelli, Maël, Renaudineau, Yves, Youinou, Pierre, Michel, Geneviève, LabEX IGO Immunothérapie Grand Ouest, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Laboratoire d'Immunologie et Immunothérapie, and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

21. Second-line drugs used in recent-onset rheumatoid arthritis in Brittany (France).

Author

Saraux, Alain, Berthelot, Jean-Marie, Chalès, Gérard, Le Henaff, Catherine, Thorel, Jean, Hoang, Sylvie, Martin, Antoine, Allain, Jérôme, Nouy-Trolle, Isabelle, Devauchelle, Valérie, Youinou, Pierre, and Le Goff, Paul

Subjects
*RHEUMATOID arthritis, *DRUGS
Abstract

Objective. The management of recent-onset rheumatoid arthritis (RA) is not well standardized. We conducted a survey of drugs prescribed to RA patients in Brittany at presentation and during the first one to three years of follow-up. Methods. A cohort of 270 patients with recent-onset inflammatory joint disease was recruited between 1995 and 1997. The evaluation at presentation included a medical history, a thorough physical examination, and a standard battery of investigations. Follow-up at six-month intervals was offered. At the last visit, between June and December 1999, a panel of five rheumatologists established that 98 patients had RA. Results. At presentation, hydroxychloroquine and injectable gold were the most widely used second-line drugs, and only two patients were offered a combination of second-line drugs. At the last visit, the most commonly used drugs were methotrexate, injectable gold, and hydroxychloroquine (23, 23, and 21 patients, respectively); only three patients were on more than one second-line drug and 38 (38/98, 39%) patients were on glucocorticoid therapy. Conclusion. Rheumatologists in Brittany prefer monotherapy with hydroxychloroquine or injectable gold as the initial treatment. Later, they rely mainly on methotrexate, injectable gold, and hydroxychloroquine, often in combination with glucocorticoid therapy. [ABSTRACT FROM AUTHOR]

Published
2002

22. [Amyloidosis and aging].

Author

Mimassi N, Youinou P, and Pennec YL

Subjects
Aged, Aged, 80 and over, Amyloidosis diagnosis, Apolipoproteins E analysis, Cerebral Amyloid Angiopathy classification, Cerebral Amyloid Angiopathy diagnosis, Cerebral Amyloid Angiopathy, Familial diagnosis, Glycosaminoglycans analysis, Humans, Serum Amyloid P-Component analysis, Aging, Amyloidosis classification
Abstract

Amyloidosis is a heterogeneous group of extracellular protein deposition diseases. Age-related amyloidosis may be systemic or localized. The systemic forms include associated-myeloma AL amyloidosis and senile systemic amyloidosis which is the only clear-cut systemic form related to age and derived from normal transthyretin. In localized amyloidosis, the fibril protein precursors are synthesized in the tissue involved by the amyloid. In most cases, localized age-related amyloidosis does not appear to cause clinical disease with the exception of amyloid associated with Alzeihmer's disease and type 2 diabetes mellitus. The significance of aortic amyloidosis, amyloidosis of seminal vesicles, amyloid of the endocrine glands, and articular amyloidosis remains unknown.

Published
2002

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