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1. [Is resistance of human immunodeficiency viruses (HIV) to nucleoside analogs an indication for their combined use?].

Author

Pépin JM, Simon F, and Brun-Vezinet F

Subjects
Acyclovir pharmacology, Drug Synergism, Drug Therapy, Combination, Female, Foscarnet pharmacology, Humans, In Vitro Techniques, Male, Didanosine pharmacology, HIV-1 drug effects, Ribavirin pharmacology, Zalcitabine pharmacology, Zidovudine pharmacology
Abstract

HIV resistance to nucleoside analogues such as zidovudine (AZT) is to date a source of concern, even if its clinical significance is yet to be determined. Phenotypic and genotypic data concerning HIV resistance will be presented, then the potential benefits of nucleoside combinations will be discussed.

Published
1993

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