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Along with the rapid development of information technologies, such as cloud computing, mobile internet and internet of things, and the promotion of IT application, all kinds of data are generated and accumulated rapidly in various ways, big data era is coming, in which enterprises are faced with both opportunities and unprecedented challenges. Various processes, from decision making to operation and from designing to marketing, are being influenced by big data in manufacturing industry. This paper, according to the nature and features of big data, analyzes and extends a classical model of organizational change, Leavitt’s model of organizational change, in order to explore the ways for enterprises to cope with challenges and seize chances of development in big data era. Then, using the extended Leavitt’s model, opportunities and challenges derive from big data are combed, and approaches to making use of big data and coping with big data are generalized from five perspectives, including task, structure, people, technology and environment.