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Kaposi sarcoma (KS), first described in 1872, is a angioproliferative neoplasm that often presents with red-purple macules in the skin. This report is of a case of classic/iatrogenic form of KS in a 79-year-old male, that had a prolonged hospitalization due to surgical complications. After discharge, he presented a red-purple macule. A biopsy was made and KS was confirmed. He was HIV negative. The patient did not required any other treatment asides of total removal of the lesion. Kaposi’s sarcoma is an uncommon disease, still very associated with HIV. This case demonstrates the importance of recognition of KS in non-HIV patients. There are four types of Kaposi’s sarcoma and the importance of its recognition in non-HIV patients.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an extremely rare form of skin lymphoma that primarily involves subcutaneous adipose tissue. SPTCL diagnosis is demanding because of its nonspecific systemic features, such as fever or weight loss, that usually mimic other more common conditions. Further complicating diagnosis, lesion biopsies are often inconclusive. For this matter, patients are frequently seen by different clinicians and may be submitted to various cutaneous biopsies before a definitive diagnosis is reached. We present the case of a 64-year-old man with a two-month history of fever and subcutaneous nodular lesions scattered by the lower limbs and torso, whose final diagnosis of SPTCL illustrates the main features of the disease as well as the challenge of its identification.

Sjögren Syndrome is a multisystemic autoimmune disease that is heterogeneous in its presentation, course and outcome. There is no single clinical, laboratorial or radiological feature that serves as gold standard for the diagnosis and/or classification of this syndrome. The occurrence of lymphoma is known to be one of the most severe complications. We report a case of a 66-year-old female diagnosed with Sjögren Syndrome secondary to systemic lupus erythematous that presented with an enlargement of the left parotid gland consistent with the diagnosis of lymphoma confirmed with biopsy. She received chemotherapy with favorable response and today is asymptomatic with hydroxychloroquine 400mg id. This case report highlights the importance of optimal interventions and active surveillance of Sjogren Syndrome, in order to achieve an early identification of its complications and to prevent worse outcomes of this disease.