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Besides cellular changes in the dermis aging takes place in the extracelluar matrix (ECM). Lack of homoeostasis leads to dysregulation and loss of collagen, elastin, and hyaluronic acid as main structures of the ECM. Adding hyaluronic acid and amino acids as important factors to reconstruct the collagen system is a very promising method to reestablish homoeostasis in the ECM. The importance of the exact concentration of the ingredients must be underlined. [ABSTRACT FROM AUTHOR]

The article describes the characteristics and applications of the biostimulator Sculptra® by Galderma. Sculptra® contains micro-particles of poly-L-lactic acid that stimulate the production of collagen in the deep dermis. Through collagen production, skin tightening, wrinkle smoothing, and volume enhancement can be achieved. The biostimulator can gradually contribute to natural and long-lasting improvements in signs of aging. In addition to Sculptra®, Galderma's aesthetic portfolio also includes other products such as neuromodulators and hyaluronic acid fillers. [Extracted from the article]