1. Herausforderungen in der mikrobiologischen Diagnostik Carbapenem resistente Enterobacterales.
- Author
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Österreicher, Leopold
- Subjects
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MULTIDRUG resistance , *HEALTH facilities , *GRAM-negative bacteria , *DIAGNOSTIC microbiology , *DRUG resistance in microorganisms , *MOBILE genetic elements - Abstract
In the field of diagnostic microbiology, multi drug resistant bacteria have become increasingly common. In order to keep up with the variety of different mechanisms of resistance, laboratories are using numerous diagnostical methods. In recent years increasing numbers of antimicrobial resistance in gram-negative bacteria, such as E. coli or Klebsiella spp., have become a major public health concern. In case of infection, these multidrug resistant organisms pose a therapeutical challenge, since treatment options are limited. In many cases, enzymes called β-lactamases are responsible for the insensitivity of gram-negative bacteria towards certain antibiotics. They are further classified as extended spec - trum β-lactamases (ESBLs), AmpC-β-lactamases or carbape - nemases. The latter hydrolyzing most available β-lactams, including carbapenems. Since these enzymes are encoded on mobile genetic elements, cross-transmission is common and especially healthcare facilities are at risk for outbreaks. The challenge for microbiology laboratories lies in rapidly and accurately identifying bacteria that possess highly transmissible mechanisms of resistance, to prevent further dissemination. Additionally, the identification of the exact mechanism of resistance is essential for optimizing antibiotic treatment, as some recently introduced antimicrobial substances are specifically designed to inhibit these enzymes. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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